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| 1 | Anti-angiogenic therapies for metastatic colorectal cancer:Current and future perspectives显示文摘Colorectal cancer(CRC)is the fourth most commonly diagnosed cancer and the second leading cause of cancer death in both men and women in the United States,with about 142820 new cases and 50830 deaths expected in 2013.Metastatic disease(mCRC)remains a challenge for oncologists worldwide due to its potential comorbidities.Recently,chemotherapy regimens containing 5-fluorouracil,leucovorin,oxaliplatin and irinotecan combinations are a standard of care in the metastatic disease.Currently,biological therapies involving vascular endothelial growth factor and epidermal growth factor receptor pathways,such as bevacizumab and cetuximab,have emerged as good option for improving mCRC patient survival.Now,aflibercept plus standard chemotherapy has also been approved in second line regimen for mCRC patients.Our review will discuss novel biological drugs and their indications for mCRC patients and will bring future perspectives in this regard. | Inês Marques António Araújo Ramon Andrade de Mello | 2013 | World Journal of Gastroenterology2013，19，44： | 3 |
| 2 | Oral intake throughout the patients’ lives after palliative metallic stent placement for malignant gastroduodenal obstruction: a retrospective multicentre study显示文摘 | Jorge M. Canena Ana C. Lagos Inês N. Marques Sara D. Patrocínio Miguel G. Tomé Manuel A. Liberato Carlos M. Rom?o António P. Coutinho Pedro M. Veiga Beatriz C. Neves Hélder D. Além José A. Gon?alves | 2012 | European Journal of Gastroenterology & Hepatology2012，，7： | 1 |
| 3 | Oral intake throughoutthe patients; lives after palliative metallic stent placement for ma-lignant gastroduodenal obstruction ; a retrospective multicentrestudy显示文摘 | Canena JM Lagos AC Marques IN | 2012 | Eur J Gastroenterol Hepatol2012，24，7： | 1 |
| 4 | Photosynthetic performance and pigment composition of leaves from two trop-ical species is determined by light quality 显示文摘 | Ramalho JC Marques NC Semedo IN | 2002 | Plant Biolo- gy2002，4，1： | 1 |
| 5 | Zebrafish cypher is important for somite formation and heart development显示文摘 | David L.M. van der Meer Ines J. Marques Jelani T.D. Leito Jaya Besser Jeroen Bakkers Edwige Schoonheere Christoph P. Bagowski | 2006 | Developmental Biology2006，，2： | 1 |
| 6 | BLEED-Myocardial Infarction Score:Predicting mid-term post-discharge bleeding events显示文摘AIM:To derive and validate a score for the prediction of mid-term bleeding events following discharge for myocardial infarction(MI).METHODS:One thousand and fifty patients admitted for MI and followed for 19.9 ± 6.7 mo were assigned to a derivation cohort.A new risk model,called BLEEDMI,was developed for predicting clinically significant bleeding events during follow-up(primary endpoint) and a composite endpoint of significant hemorrhage plus all-cause mortality(secondary endpoint),incorporating the following variables:age,diabetes mellitus,arterial hypertension,smoking habits,blood urea nitrogen,glomerular filtration rate and hemoglobin at admission,history of stroke,bleeding during hospitalization or previous major bleeding,heart failure during hospitalization and anti-thrombotic therapies prescribedat discharge.The BLEED-MI model was tested for calibration,accuracy and discrimination in the derivation sample and in a new,independent,validation cohort comprising 852 patients admitted at a later date.RESULTS:The BLEED-MI score showed good calibration in both derivation and validation samples(HosmerLemeshow test P value 0.371 and 0.444,respectively) and high accuracy within each individual patient(Brier score 0.061 and 0.067,respectively).Its discriminative performance in predicting the primary outcome was relatively high(c-statistic of 0.753 ± 0.032 in the derivation cohort and 0.718 ± 0.033 in the validation sample).Incidence of primary/secondary endpoints increased progressively with increasing BLEED-MI scores.In the validation sample,a BLEED-MI score below 2 had a negative predictive value of 98.7%(152/154) for the occurrence of a clinically significant hemorrhagic episode during follow-up and for the composite endpoint of post-discharge hemorrhage plus all-cause mortality.An accurate prediction of bleeding events was shown independently of mortality,as BLEED-MI predicted bleeding with similar efficacy in patients who did not die during follow-up:Area Under the Curve 0.703,Hosmer-Lemeshow test P value 0.547,Brier score 0.060;low-risk(BLEED-MI score 0-3) event rate:1.2%;intermediate risk(score 4-6) event rate:5.6%;high risk(score ≥ 7) event rate:12.5%.CONCLUSION:A new bedside prediction-scoring model for post-discharge mid-term bleeding has been derived and preliminarily validated.This is the first score designed to predict mid-term hemorrhagic risk in patients discharged following admission for acute MI.This model should be externally validated in larger cohorts of patients before its potential implementation. | Sérgio Barra Rui Providência Francisca Caetano Inês Almeida Luís Paiva Paulo Dinis António Leito Marques | 2013 | World Journal of Cardiology2013，5，6： | 0 |
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