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您的检索式：作者名="Marta Machnik"
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| 1 | KRAB-ZFPs and cancer stem cells显示文摘Studies on carcinogenesis continue to provide new information about different disease-related processes.Among others,much research has focused on the involvement of cancer stem cells(CSCs)in tumor initiation and progression.Studying the similarities and dif-ferences between CSCs and physiological stem cells(SCs)allows for a better understanding of cancer biology.Recently,it was shown that stem cell identity is partially governed by the Kruppel-associated box domain zinc finger proteins(KRAB-ZFPs),the biggest family of tran-scription regulators.Several KRAB-ZFP factors exert a known effect in tumor cells,acting as tumor suppressor genes(TSGs)or oncogenes,yet their role in CSCs is still poorly characterized.Here,we review recent studies regarding the influence of KRAB-ZFPs and their cofactor pro-tein TRIM28 on CSCs phenotype,stemness features,migration and invasion potential,metas-tasis,and expression of parental markers. | Anna Olechnowicz Urszula Oleksiewicz Marta Machnik | 2023 | Genes & Diseases2023，10，5： | 0 |
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