|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Chemokine expression in hepatocellular carcinoma versus colorectal liver metastases显示文摘AIM: To evaluate and compare the expression profiles of CXCL12 (SDF-1), CCL19 (MIP-3β), CCL20 (MIP-3α) and CCL21 (6Ckine, Exodus2) and their receptors on RNA and protein levels in hepatocellular carcinoma (HCC) versus colorectal liver metastases (CRLM) and to elucidate their impact on the carcinogenesis and progression of malignant liver diseases. METHODS: Chemokine expression was analyzed by RT-PCR and ELISA in 11 cases of HCC specimens and in 23 cases of CRLM and corresponding adjacent non- tumorous liver tissues, respectively. Expressions of their receptors CXCR4, CCR6 and CCR7 were analyzed by RT- PCR and Western blot analysis in the same cases of HCC and CRLM. RESULTS: Significant up-regulation for CCL20/CCR6 was detected in both cancer types. Moreover, CCL20 demonstrated significant overexpression in CRLM in relation to the HCC tissues. Being significantly up- regulated only in CRLM, CXCR4 displayed an aberrant expression pattern with respect to the HCC tissues. CONCLUSION: Correlation of CXCR4 expression with CRLM suggests CXCR4 as a potential predictive factor for CRLM. High level expression of CCL20 and its receptor CCR6 in HCC and CRLM with marked up- regulation of CCL20 in CRLM in relation to HCC tissues indicates involvement of the CCL20/CCR6 ligand-receptor pair in the carcinogenesis and progression of hepatic malignancies. | Claudia Rubie Vilma Oliveira Frick Mathias Wagner Christina Weber Bianca Kruse Katja Kempf Jochen Knig Bettina Rau Martin Schilling | 2006 | World Journal of Gastroenterology2006，12，41： | 24 |
| 2 | Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer显示文摘AIM: To investigate the expression profile of IL-8 in inflammatory and malignant colorectal diseases to evaluate its potential role in the regulation of colorectal cancer (CRC) and the development of colorectal liver metastases (CRLM). METHODS: IL-8 expression was assessed by quantitative real-time PCR (Q-RT-PCR) and the enzyme-linked immunosorbent assay (ELISA) in resected specimens from patients with ulcerative colitis (UC, n = 6) colorectal adenomas (CRA, n = 8), different stages of colorectal cancer (n = 48) as well as synchronous and metachronous CRLM along with their corresponding primary colorectal tumors (n = 16). RESULTS: IL-8 mRNA and protein expression was significantly up-regulated in all pathological colorectal entities investigated compared with the corresponding neighboring tissues. However, in the CRC specimens IL-8 revealed a significantly more pronounced overexpression in relation to the CRA and UC tissues with an average 30-fold IL-8 protein up-regulation in the CRC specimens in comparison to the CRA tissues. Moreover, IL-8 expression revealed a close correlation with tumor grading. Most interestingly, IL-8 up-regulation was most enhanced in synchronous and metachronous CRLM, if compared with the corresponding primary CRC tissues. Herein, an up to 80-fold IL-8 overexpression in individual metachronous metastases compared to normal tumor neighbor tissues was found. CONCLUSION: Our results strongly suggest an association between IL-8 expression, induction and progression of colorectal carcinoma and the development of colorectal liver metastases. | Claudia Rubie Vilma Oliveira Frick Sandra Pfeil Mathias Wagner Otto Kollmar Berit Kopp Stefan Grber Bettina M Rau Martin K Schilling | 2007 | World Journal of Gastroenterology2007，13，37： | 12 |
| 3 | Effect of preoperative FOLFOX chemotherapy on CCL20/CCR6 expression in colorectal liver metastases显示文摘AIM:To evaluate the influence of preoperative FOLFOX chemotherapy on CCL20/CCR6 expression in liver metastases of stage Ⅳ colorectal cancer(CRC) patients.METHODS:Using Real Time-PCR,enzyme-linked immunosorbent assay,Western Blots and immunohistochemistry,we have analyzed the expression of CCL20,CCR6 and proliferation marker Ki-67 in colorectal liver metastasis(CRLM) specimens from stage Ⅳ CRC patients who received preoperative FOLFOX chemotherapy(n = 53) and in patients who did not receive FOLFOX chemotherapy prior to liver surgery(n = 29).RESULTS:Of the 53 patients who received FOLFOX,time to liver surgery was ≤ 1 mo in 14 patients,≤ 1 year in 22 patients and > 1 year in 17 patients,respectively.In addition,we investigated the proliferation rate of CRC cells in liver metastases in the different patient groups.Both CCL20 and CCR6 mRNA and protein expression levels were significantly increased in patients who received preoperative FOLFOX chemotherapy ≤ 12 mo before liver surgery(P < 0.001) in comparison to patients who did not undergo FOLFOX treatment.Further,proliferation of CRLM cells as measured by Ki-67 was increased in patients who underwent FOLFOX treatment.CCL20 and CCR6 expression levels were significantly increased in CRLM patients who had undergone preoperative FOLFOX chemotherapy.CONCLUSION:This chemokine/receptor up-regulation could lead to increased proliferation/migration through an autocrine mechanism which might be used by surviving metastatic cells to escape cell death caused by FOLFOX. | Claudia Rubie Vilma Oliveira Frick Pirus Ghadjar Mathias Wagner Christoph Justinger Stefan Graeber Jens Sperling Otto Kollmar Martin K Schilling | 2011 | World Journal of Gastroenterology2011，17，26： | 5 |
| 4 | Optimization of the distribution of compressed natural gas(CNG) refueling stations:Swiss case studies显示文摘 | Martin Frick Axhausen K W Gian Carle | 2007 | Transportation Research Part D:Transport and Environment2007，12，1： | 1 |
| 5 | Enhanced ENA-78 and IL-8 Expression in Patients with Malignant Pancreatic Diseases显示文摘 | Vilma Oliveira Frick Claudia Rubie Mathias Wagner Stefan Graeber Henner Grimm Berit Kopp Bettina M. Rau Martin K. Schilling | 2008 | Pancreatology . 2008 (4-5)2008，，4： | 1 |
| 6 | APOA5 gene variants, lipoprotein particle distribution , and progression of coronary heart disease :results from the LOCAT study 显示文摘 | Talmud PJ Martin S Taskinen MR Frick MH Nieminen MS Kesaniemi YA | 2004 | J Lipid Res2004，45，4： | 1 |
| 7 | Life cycle assessment of geothermal binary power plants using enhanced low-temperature reservoirs 显示文摘 | STEPHANIE FRICK MARTIN KALTSCHMITY GERD SCHRODER | 2010 | Energy2010，35，5： | 1 |
| 8 | miR-21 functionally interacts with the 3′UTR of chemokine CCL20 and down-regulates CCL20 expression in miR-21 transfected colorectal cancer cells显示文摘 | Benjamin Vicinus Claudia Rubie Sabrina K. Faust Vilma Oliveira Frick Pirus Ghadjar Mathias Wagner Stefan Graeber Martin K. Schilling | 2011 | Cancer Letters2011，，1： | 1 |
| 9 | Dinosaur body temperatures determined from isotopic(13C-18O)ordering in fossil biominerals显示文摘 | Eagle R.A Tütken Martin T.S Tripati A.K Fricke H.C Connely M Cifelli R.L Eiler J.M | | 0，，： | 1 |
| 10 | APOA5 gene variants,lipoprotein particle distribution,and progression of coronary heart disease:results from the LOCAT study显示文摘 | Talmud PJ Martin S Taskinen MR Frick MH Nieminen MS Kesaniemi YA | 2004 | J Lipid Res2004，45，4： | 1 |
| 11 | A screen for bacterial endosymbionts in the model organisms Tribolium castaneum, T. confusum, Callosobruchus maculatus, and related species显示文摘象 Wolbachia 那样的繁殖寄生虫在节肢动物之中是极其普遍的并且能在他们的主人的繁殖和健康上有大影响。未被发现的感染能因此使集中于繁殖隔离的主人行为,复制,健康,和度的方面的大量研究的结果惊讶。这个潜在的问题被有货模型系统果蝇 melanogaster 的调查 Wolbachia 感染的发生的工作已经加重了。这里,我们调查进一步通常使用的模型节肢动物的实验室股票的一个范围,特别集中于面粉甲壳虫 Tribolium castaneum 和 Tribolium confusum,豇豆象鼻虫 Callosobruchus maculatus 和相关种类(翘目:Tenebrionidae 和 Bruchidae ) 。这些种类是普遍的存储了产品害虫因此有共生者的感染的知识进一步在通知 biocontrol 措施有潜在的使用。甲壳虫与 3 个已知的微生物引起的繁殖寄生虫为感染被估计:Wolbachia,立克次休属微生物, Spiroplasma。有一些这些微生物的感染在一些股票学习了的实验室被发现,尽管全面感染是相对稀罕的。多半在这些或另外的种类和以前的研究的类型发现感染最被假装的后果被讨论。 | Sara L. Goodacre Claudia Fricke Oliver Y. Martin | 2015 | Insect Science2015，22，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员