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| 1 | Distribution,function and physiological role of melatonin in the lower gut显示文摘Melatonin is a hormone with endocrine, paracrine andautocrine actions. It is involved in the regulation of multiple functions, including the control of the gastroin-testinal (GI) system under physiological and pathophys-iological conditions. Since the gut contains at least 400times more melatonin than the pineal gland, a reviewof the functional importance of melatonin in the gutseems useful, especially in the context of recent clinicaltrials. Melatonin exerts its physiological effects throughspecific membrane receptors, named melatonin-1 re-ceptor (MT1), MT2 and MT3. These receptors can befound in the gut and their involvement in the regulationof GI motility, inflammation and pain has been reportedin numerous basic and clinical studies. Stable levels ofmelatonin in the lower gut that are unchanged follow-ing a pinealectomy suggest local synthesis and, further more, implicate physiological importance of endogenous melatonin in the GI tract. Presently, only a small number of human studies report possible beneficial and also possible harmful effects of melatonin in case reports and clinical trials. These human studies include patients with lower GI diseases, especially patients with irritable bowel syndrome, inflammatory bowel disease and colorectal cancer. In this review, we summarize the presently available information on melatonin effects in the lower gut and discuss available in vitro and in vivo data. We furthermore aim to evaluate whether melatonin may be useful in future treatment of symptoms or diseases involving the lower gut. | Chun-Qiu Chen Jakub Fichna Mohammad Bashashati Yong-Yu Li Martin Storr | 2011 | World Journal of Gastroenterology2011，17，34： | 13 |
| 2 | Inhibition of ileal bile acid transporter:An emerging therapeutic strategy for chronic idiopathic constipation显示文摘Chronic idiopathic constipation is a common disorder of the gastrointestinal tract that encompasses a wide profile of symptoms. Current treatment options for chronic idiopathic constipation are of limited value; therefore, a novel strategy is necessary with an increased effectiveness and safety. Recently, the inhibition of the ileal bile acid transporter has become a promising target for constipation-associated diseases. Enhanced delivery of bile acids into the colon achieves an accelerated colonic transit, increased stool frequency, and relief of constipationrelated symptoms. This article provides insight into the mechanism of action of ileal bile acid transporter inhibitors and discusses their potential clinical use for pharmacotherapy of constipation in chronic idiopathic constipation. | Paula Mosińska Jakub Fichna Martin Storr | 2015 | World Journal of Gastroenterology2015，21，24： | 4 |
| 3 | Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain显示文摘AIM: To characterize the antinociceptive action of the novel melatonin receptor(MT) agonists, Neu-P11 and Neu-P12 in animal models of visceral pain. METHODS: Visceral pain was induced by intracolonic(ic) application of mustard oil or capsaicin solution or by intraperitoneal(ip) administration of acetic acid. Neu-P11, Neu-P12, or melatonin were given ip or orally and their effects on pain-induced behavioral responses were evaluated. To identify the receptors involved, thenon-selective MT1/MT2 receptor antagonist luzindole, the MT2 receptor antagonist 4-P-PDOT, or the μ-opioid receptor antagonist naloxone were injected ip or intracerebroventricularly(icv) prior to the induction of pain. RESULTS: Orally and ip administered melatonin, Neu-P11, and Neu-P12 reduced pain responses in a dose-dependent manner. Neu-P12 was more effective and displayed longer duration of action compared to melatonin. The antinociceptive effects of Neu-P11 or Neu-P12 were antagonized by ip or icv. administered naloxone. Intracerebroventricularly, but not ip administration of luzindole or 4-P-PDOT blocked the antinociceptive actions of Neu-P11 or Neu-P12. CONCLUSION: Neu-P12 produced the most potent and long-lasting antinociceptive effect. Further development of Neu-P12 for future treatment of abdominal pain seems promising. | Chunqiu Chen Jakub Fichna Moshe Laudon Martin Storr | 2014 | World Journal of Gastroenterology2014，20，5： | 3 |
| 4 | Nociceptin effect on intestinal motility depends on opioidreceptor like-1 receptors and nitric oxide synthase colocalization显示文摘AIM: To study the effect of the opioid-receptor like-1(ORL1) agonist nociceptin on gastrointestinal(GI)myenteric neurotransmission and motility. METHODS: Reverse transcriptase- polymerase chain reaction and immunohistochemistry were used to localize nociceptin and ORL1 in mouse tissues. Intracellular electrophysiological recordings of excitatory and inhibitory junction potentials(EJP, IJP) were made in a chambered organ bath. Intestinal motility was measured in vivo. RESULTS: Nociceptin accelerated whole and upper GI transit, but slowed colonic expulsion in vivo in an ORL1-dependent manner, as shown using [Nphe1]NOC and AS ODN pretreatment. ORL1 and nociceptin immunoreactivity were found on enteric neurons. Nociceptin reduced the EJP and the nitric oxide-sensitive slow IJP in an ORL1-dependent manner, whereas the fast IJP was unchanged. Nociceptin further reduced the spatial spreading of the EJP up to 2 cm. CONCLUSION: Compounds acting at ORL1 are good candidates for the future treatment of disorders associated with increased colonic transit, such as diarrhea or diarrhea-predominant irritable bowel syndrome. | Andrei Sibaev Jakub Fichna Dieter Saur Birol Yuece Jean-Pierre Timmermans Martin Storr | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，3： | 2 |
| 5 | Metabolomics: is it useful for inflammatory bowel diseases?显示文摘 | Martin Storr Hans J. Vogel Rudolf Schicho | 2013 | Current Opinion in Gastroenterology2013，，： | 2 |
| 6 | STW 5 (Iberogast ? )—a safe and effective standard in the treatment of functional gastrointestinal disorders显示文摘 | Bertram Ottillinger Martin Storr Peter Malfertheiner Hans-Dieter Allescher | 2013 | Wiener Medizinische Wochenschrift2013，，3： | 1 |
| 7 | Adolescent ecstasyand other drug use in the national survey of parents and youth: therole of sensation - seeking, parental monitoring and peer* s druguse 显示文摘 | Martins S S Storr C L Alexandre P K | 2008 | Addilctive Behaviors2008，33，7： | 1 |
| 8 | Cytokines and irritable bowel syndrome: Where do we stand?显示文摘 | Mohammad Bashashati Nima Rezaei Christopher N. Andrews Chun-Qiu Chen Nasser Ebrahimi Daryani Keith A. Sharkey Martin A. Storr | 2011 | Cytokine2011，，2： | 1 |
| 9 | ORL-1 Receptor Mediates the Action of Nociceptin on Ascending Myenteric Reflex Pathways in Rats显示文摘 | Birol Yüce Andrei Sibaev Andreas Haaken Dieter Saur Hans–Dieter Allescher Burkhard G?ke Jean–Pierre Timmermans Martin Storr | 2007 | Gastroenterology2007，，2： | 1 |
| 10 | Comparisons in the epidemiology, diagnostic features and cure rate by transsphenoidal surgery between paediatric and adult-on- set Cushing's disease 显示文摘 | Storr HL Alexandraki KI Martin L | 2011 | Eur J Endocfinol2011，164，5： | 1 |
| 11 | Comparisons in the epidemiology, diagnostic features and cure rate by transsphenoidal surgery between paediatric and adult-on- set Cushing's disease显示文摘 | Storr HL Alexandraki KI Martin L | 2011 | Eur J Endocrinol2011，164，5： | 1 |
| 12 | Synthesis and biological evaluation of novel peripherally active morphiceptin analogs显示文摘 | Katarzyna Gach Jean Claude do-Rego Jakub Fichna Martin Storr Dick Delbro Geza Toth Anna Janecka | 2010 | Peptides2010，，8： | 1 |
| 13 | Bay street as contested space显示文摘 | Martin N P Storr V H | 2012 | Space and Culture2012，15，4： | 1 |
| 14 | Orally Ingested Urban Particulate Matter Induces a PRO-Inflammatory Response and Decreases Microflora Diversity显示文摘 | Lisa Kish Naomi Hotte Edwin Cheng Kevin P. Rioux Gilaad G. Kaplan Renaud Vincent Martin Storr Karen Madsen | 2011 | Gastroenterology2011，，5： | 1 |
| 15 | 速激肽对大鼠小肠上行及下行反射通路的作用(英文)显示文摘瞄准:在老鼠在上升反射小径上检验 tachykinins 的效果小肠,我们使用了不同选择 neurokinin (NK ) 受体对手(RA ) :一) NK1-RA:GR-82334 和 CP-96.345, b ) NK2-RA:MEN-10.376 和 L-659.877。目的是进一步的在上升上调查物质 P (SP ) 的效果有刺激性、下降的禁止的反射小径。方法:老鼠回肠(在长度的 10 厘米) 的整个片断在机关洗澡被学习。圆肌肉的上升收缩被肛门电的刺激得到(3 Hz, 1 ms, 20 V ) 并且由一个酒的压力计的系统作为 intraluminal 压力的变化测量了刺激地点的 2 厘米和 4 厘米或广告。结果:GR-82334 和 CP-96.345 (NK1-RA ) 在 4 厘米的距离引起了口头的收缩的重要剂量相关的抑制:GR-82334 [区域:-10 %+/- 8 %(10 nmol/L ) ;-29 %+/-10 %(1000 nmol/L ) 。 | Andreas HAHN, Martin STORR, Hans-Dieter ALLESCHER(// Medizinische Klinik und Poliklinik der Technischen Universitat Munchen, 81675 Munchen, Germany) | 2002 | Acta Pharmacologica Sinica2002，23，4： | 0 |
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