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| 1 | Portal vein thrombosis, mortality and hepatic decompensation in patients with cirrhosis: A meta-analysis显示文摘AIM: To determine the clinical impact of portal vein thrombosis in terms of both mortality and hepatic decompensations(variceal hemorrhage, ascites, portosystemic encephalopathy) in adult patients with cirrhosis.METHODS: We identified original articles reported through February 2015 in MEDLINE, Scopus, Science Citation Index, AMED, the Cochrane Library, and relevant examples available in the grey literature. Two independent reviewers screened all citations for inclusion criteria and extracted summary data. Random effects odds ratios were calculated to obtain aggregate estimates of effect size across included studies, with 95%CI.RESULTS: A total of 226 citations were identified and reviewed, and 3 studies with 2436 participants were included in the meta-analysis of summary effect. Patients with portal vein thrombosis had an increased risk of mortality(OR = 1.62, 95%CI: 1.11-2.36, P = 0.01). Portal vein thrombosis was associated with an increased risk of ascites(OR = 2.52, 95%CI: 1.63-3.89, P < 0.001). There was insufficient data available to determine the pooled effect on other markers of decompensation including gastroesophageal variceal bleeding or hepatic encephalopathy. CONCLUSION: Portal vein thrombosis appears to increase mortality and ascites, however, the relatively small number of included studies limits more generalizable conclusions. More trials with a direct comparison group are needed. | Jonathan G Stine Puja M Shah Scott L Cornella Sean R Rudnick Marwan S Ghabril George J Stukenborg Patrick G Northup | 2015 | World Journal of Hepatology2015，7，27： | 42 |
| 2 | M2BPGi for assessing liver fibrosis in patients with hepatitis C treated with direct-acting antivirals显示文摘BACKGROUND Assessing liver fibrosis is important for predicting the efficacy of direct-acting antivirals(DAAs)and patient prognosis.Non-invasive techniques to assess liver fibrosis are becoming important.Recently,serum Mac-2 binding protein glycosylation isomer(M2BPGi)was identified as a non-invasive marker of liver fibrosis.AIM To investigate the diagnostic accuracy of M2BPGi in assessing liver fibrosis in patients with chronic hepatitis C(CHC)treated with DAAs.METHODS From December 2017 to August 2018,80 treatment-naive adult patients with CHC who were eligible for DAAs therapy were consecutively enrolled in this observational cohort study.For 12 weeks,65 patients were treated with sofosbuvir/daclatasvir,and 15 patients were treated with sofosbuvir/daclatasvir and a weight-based dose of ribavirin at knowledge and technology association for hepatitis C management clinic,Cairo,Egypt.We measured serum M2BPGi levels,PAPAS index,fibrosis-4(FIB-4)score and liver stiffness measurements(LSM)at baseline and 12 weeks after the end of treatment.Serum M2BPGi levels were measured using enzyme-linked immunosorbent assay.RESULTS All patients achieved sustained virologic response(SVR12)(100%).Serum M2BPGi levels,LSM,FIB-4 score and PAPAS index decreased significantly at SVR12(P<0.05).Serum M2BPGi levels correlated positively with LSM at baseline and SVR12(P<0.001).At baseline,compared with the FIB-4 score and PAPAS index,M2BPGi was the best marker to distinguish patients with grade F4 fibrosis(AUC=0.801,P<0.001),patients with grade F2 from grade F0-1 fibrosis(AUC=0.713,P=0.012),patients with grade F3-4 from grade F0-2 fibrosis(AUC=0.730,P<0.001),and patients with grade F2-4 from grade F0-1 fibrosis(AUC=0.763,P<0.001).At SVR12,M2BPGi had the greatest AUCs for differentiating patients with grade F4 fibrosis(AUC=0.844,P<0.001),patients with grade F3 from grade F0-2 fibrosis(AUC=0.893,P=0.002),patients with grade F3-4 from grade F0-2 fibrosis(AUC=0.891,P<0.001),and patients with grade F2-4 from grade F0-1 fibrosis(AUC=0.750,P<0.001).CONCLUSION M2BPGi is a reliable marker for the non-invasive assessment and prediction of liver fibrosis regression in patients with CHC who achieved an SVR with DAAs therapy. | Shereen A Saleh Mohamed M Salama Marwan M Alhusseini Ghada A Mohamed | 2020 | World Journal of Gastroenterology2020，26，21： | 3 |
| 3 | Recurrence plots for the analysis of complex systems显示文摘 | Norbert Marwan M Carmen Romano Marco Thiel | 2007 | Physics Reports2007，438，5： | 1 |
| 4 | Radiation exposure and image quality in staged low-dose protocols for coronary dual-source CT angiography: a randomized comparison显示文摘 | Pflederer T Jakstat J Marwan M | 2010 | Eur Radiol2010，20，5： | 1 |
| 5 | Coronary computedtomography angiography with a consistent dose below 1mSv u-sing prospectively electrocardiogram-triggered high-pitch spiralacquisition显示文摘 | Achenbach S Marwan M Ropers D | 2010 | Eur Herat J2010，31，： | 1 |
| 6 | In vivo CT detection of lipid- rich coronary artery atherosclerotic plaques using quantitative histogram analysis:a head to head comparison with IVUS 显示文摘 | Marwan M Taher MA E1 Meniawy K | 2011 | Atherosclerosis2011，215，1： | 1 |
| 7 | Noninvasive assessment of cor- onary in-stent restenosis by dual-source computed tomography 显示文摘 | Pflederer T Marwan M Renz A | 2009 | Am J Cardiol2009，103，6： | 1 |
| 8 | Coronary computed tomography angiography with a consistent dose below I rosy us- ing prospectively electrocardiogrmn-triggcred high-pitch spiral acquisition 显示文摘 | Achenbach S Marwan M Ropers D et at | 2009 | European Heart Journal2009，31，2： | 1 |
| 9 | Radiation exposure and image quality in staged low-dose protocols for coronary dual-source CT angiography: a randomized comparison显示文摘 | Pflederer T Jakstat J Marwan M | 2010 | Eur Radiol2010，20，： | 1 |
| 10 | High-pitch spiral ac-quisition:a new scan mode for coronary CT angiography显示文摘 | Achenbach S Marwan M Schepis T | 2009 | JCardiovasc Comput Tomogr2009，3，： | 1 |
| 11 | Comparison of dual-source computed tomography for the quantification of the aortic valve area in patients with aortic stenosis versus transthoracic echocardiography and invasive hemodynamic assessment显示文摘 | Ropers D Ropers U Marwan M | 2009 | Am J Cardiol2009，104，11： | 1 |
| 12 | High-pitch spiral acquisition: a new scan mode for coronary CT angiography显示文摘 | Achenbach S Marwan M Schepis T | 2009 | :l Cardiovasc Comput Tomogr2009，3，： | 1 |
| 13 | The neuroprotective properties ofcalorie restriction,the ketogenic diet,and ketone bodies显示文摘 | Marwan M Jong MR Mattson MP | 2009 | BrainRes Rev2009，59，2： | 1 |
| 14 | Psoralens stimulate mouse melanocyte and melanoma tyrosinase activ- ity in the absence of ultraviolet light 显示文摘 | Marwan M M Jiang J W Castrucci A M | 1990 | Pigment Cell Res1990，3，4： | 1 |
| 15 | Prrospectively ECG triggered high pilch spiral acquisition for coronary CT angiog-raphy using dual source CT: technique and initial experience 显示文摘 | Lell M Marwan M Schepis T | 2009 | EurRadiol2009，19，11： | 1 |
| 16 | Quantification of noncal- cified coronary atherosclerotic plaques with dual source computed tomography:comparison to intravascular ultrasound显示文摘 | Schepis T Marwan M Pflederer T | 2010 | Heart2010，96，8： | 1 |
| 17 | Prospectively ECG-triggered high-pitch spiral acquisition for coronary CT angiography using dual source CT:technique and initial experience显示文摘 | Lell M Marwan M Schepis T | 2009 | Eur Radiol2009，19，11： | 1 |
| 18 | Complete recovery after out-of-hospital cardiac arrest with prolonged (59 rain) mechanical cardiopulmonary resuscitation, mild therapeutic hypothermia and complex percutaneous coronary intervention for ST-elevation myocardial infarction显示文摘 | Zimmermann S Rohde D Marwan M | 2014 | Heart Lung2014，43，1： | 1 |
| 19 | In vivo CT detection of lip- id-rich coronary artery atherosclerotic plaques using quantitative histogram analysisa head to head comparison with IVUS显示文摘 | Marwan M Taher MA EI MK | 2011 | Atherosclerosis2011，215，11： | 1 |
| 20 | Automated three-dimensional quantification of noncalcified coronary plaque from coronary CT angiography: comparison with intravascular US显示文摘 | Dey D Schepis T Marwan M | 2000 | Radiology2000，257，： | 1 |
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