|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Some results on the index of unicyclic graph显示文摘 | Belardo F Marzi E M L Simic S K | 2006 | Linear Algebra Appl2006，416，： | 1 |
| 2 | The G/C915 polymorphism of transforming growth factor beta1 is associated with human longevity: a study in Italian centenarians 显示文摘 | Carrieri G Marzi E Olivieri F | 2004 | Aging Cell2004，3，6： | 1 |
| 3 | The G/C915 polymorphism of transforming growth factor 1 is associated with human longevity:a study in Italian centenarians显示文摘 | Carrieri G Marzi E Olivieri F etal | 2004 | Aging Cell2004，3，6： | 1 |
| 4 | Fecal acidorrhea显示文摘 | Bustos Fernandez L Gonzales E Marzi A | 1971 | N Engl J Med1971，284，6： | 1 |
| 5 | A revised car- bon preference index显示文摘 | Marzi R Torkelson B E Olson R K | 1993 | Organic Geochemistry1993，20，8： | 1 |
| 6 | The treatment of fistulae and ureteral stenosis after kidney transplantation显示文摘 | Li Marzi V Filocamo MT Dottolo E | 2005 | Transplant Proc2005，37，6： | 1 |
| 7 | Openprostatectomy in benign prostatic hyperplasia: 10-yearexperience in ItaIy显示文摘 | MEARINI E MARZI M MEARINI L | 1998 | Eur Urol1998，34，： | 1 |
| 8 | Life cycle assessment of ship- generated waste management of Luka Koper显示文摘 | ZUIN S BELAC E MARZI B | 2009 | Waste Man- agement2009，29，12： | 1 |
| 9 | Open prostatectomy in benign prostatic hyperplasia: 10-year experience in Italy显示文摘 | Mearini E Marzi M Mearini L | 1998 | Eur Urol1998，34，： | 1 |
| 10 | Connected graphs of fixed order and size with maximal index: structural considerations 显示文摘 | Simic S K Li Marzi E M Belardo F | 2004 | Le Matematiche2004，59，12： | 1 |
| 11 | The treatment of fistulae and ureteral stenosis after kidney transplantation 显示文摘 | Li Marzi V Filocamo M T Dattolo E | 2005 | Transplantation2005，37，6： | 1 |
| 12 | Some Results on The Index of Unicyclic Graphs显示文摘 | Belardo F Marzi E M L Simic S K | 2006 | Linear Algebra Appl2006，416，： | 1 |
| 13 | On the spectral ra- dius of unicyclic graphs with prescribed, degree sequence显示文摘 | BELARDO F LI MARZI E M SIMIC'S K | 2010 | Linear Algebra Application2010，432，9： | 1 |
| 14 | Trees with minimal index and diameter at most four 显示文摘 | Belardo F E M Li Marzi Simic S K | 2010 | Discrete Math2010，310，： | 1 |
| 15 | Proton mobility in 2- substituted 1,3-dichlorobenzenes : ' ortho' α ' meta' metalation 显示文摘 | Sehlosser M Heiss C Marzi E | 2006 | European Journal of Organic Chemistry2006，，19： | 1 |
| 16 | On the spectral radius of unicyclic graphs with prescribed degree sequence显示文摘 | BELARDO F MARZI E M L SIMICS K | 2010 | Linear Algebra and its Applications2010，432，9： | 1 |
| 17 | Effect of Aspergillus niger prolyl endopeptidase in patients with celiac disease on a long-term gluten-free diet显示文摘BACKGROUND The gluten-free diet(GFD)has limitations,and there is intense research in the development of adjuvant therapies.AIM To examine the effects of orally administered Aspergillus niger prolyl endopeptidase protease(AN-PEP)on inadvertent gluten exposure and symptom prevention in adult celiac disease(CeD)patients following their usual GFD.METHODS This was an exploratory,double-blind,randomized,placebo-controlled trial that enrolled CeD patients on a long-term GFD.After a 4-wk run-in period,patients were randomized to 4 wk of two AN-PEP capsules(GliadinX;AVI Research,LLC,United States)at each of three meals per day or placebo.Outcome endpoints were:(1)Average weekly stool gluten immunogenic peptides(GIP)between the run-in and end of treatments and between AN-PEP and placebo;(2)celiac symptom index(CSI);(3)CeD-specific serology;and(4)quality of life.Stool samples were collected for GIP testing by ELISA every Tuesday and Friday during run-ins and treatments.RESULTS Forty patients were randomized for the intention-to-treat analysis,and three were excluded from the per-protocol assessment.Overall,628/640(98.1%)stool samples were collected.GIP was undetectable(<0.08μg/g)in 65.6%of samples,and no differences between treatment arms were detected.Only 0.5%of samples had GIP concentrations sufficiently high(>0.32μg/g)to potentially cause mucosal damage.Median GIP concentration in the AN-PEP arm was 44.7%lower than in the run-in period.One-third of patients exhibiting GIP>0.08μg/g during run-in had lower or undetectable GIP after AN-PEP treatment.Compared with the run-in period,the proportion of symptomatic patients(CSI>38)in the AN-PEP arm was significantly lower(P<0.03).AN-PEP did not result in changes in specific serologies.CONCLUSION This exploratory study conducted in a real-life setting revealed high adherence to the GFD.The AN-PEP treatment did not significantly reduce the overall GIP stool concentration.However,given the observation of a significantly lower prevalence of patients with severe symptoms in the AN-PEP arm,further clinical research is warranted. | Juan Pablo Stefanolo Verónica Segura Martina Grizzuti Abel Heredia Isabel Comino Ana Florencia Costa Roberto Puebla María Paz Temprano Sonia Isabel Niveloni Gabriel de Diego María E Oregui Edgardo Gustavo Smecuol Mauricio C de Marzi Elena F Verdú Carolina Sousa Julio César Bai | 2024 | World Journal of Gastroenterology2024，30，11： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员