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| 1 | Cervical inlet patch-optical coherence tomography imaging and clinical significance显示文摘AIM:To demonstrate the feasibility of optical coherence tomography(OCT)imaging in differentiating cervical inlet patch(CIP)from normal esophagus,Barrett'sesophagus(BE),normal stomach and duodenum. METHODS:This study was conducted at the Veterans Affairs Boston Healthcare System(VABHS).Patients undergoing standard esophagogastroduodenoscopy at VABHS,including one patient with CIP,one representative patient with BE and three representative normal subjects were included.White light video endoscopy was performed and endoscopic 3D-OCT images were obtained in each patient using a prototype OCT system.The OCT imaging probe passes through the working channel of the endoscope to enable simultaneous video endoscopy and 3D-OCT examination of the human gastrointestinal(GI)tract.Standard hematoxylin and eosin(H and E)histology was performed on biopsy or endoscopic mucosal resection specimens in order to compare and validate the 3D-OCT data. RESULTS:CIP was observed from a 68-year old male with gastroesophageal reflux disease.The CIP region appeared as a pink circular lesion in the upper esophagus under white light endoscopy.OCT imaging over the CIP region showed columnar epithelium structure,which clearly contrasted the squamous epithelium structure from adjacent normal esophagus.3D-OCT images obtained from other representative patients demonstrated distinctive patterns of the normal esophagus,BE,normal stomach,and normal duodenum bulb.Microstructures,such as squamous epithelium,lamina propria, muscularis mucosa,muscularis propria,esophageal glands,Barrett's glands,gastric mucosa,gastric glands, and intestinal mucosal villi were clearly observed with OCT and matched with H and E histology.These results demonstrated the feasibility of using OCT to evaluate GI tissue morphology in situ and in real-time. CONCLUSION:We demonstrate in situ evaluation of CIP microstructures using 3D-OCT,which may be a useful tool for future diagnosis and follow-up of patients with CIP. | Chao Zhou Tejas Kirtane Tsung-Han Tsai Hsiang-Chieh Lee Desmond C Adler Joseph M Schmitt Qin Huang James G Fujimoto Hiroshi Mashimo | 2012 | World Journal of Gastroenterology2012，18，20： | 3 |
| 2 | The effect of positive end-expiratory pressure and continuous positive airway pressure on the oxygenation and shunt fraction during one-lung ventilation with propofol anesthesia显示文摘 | Fujiwara M Abe K Mashimo T | 2001 | J Clin Anesth2001，13，7： | 1 |
| 3 | Characterization of the TGF beta 1-inducible hic-5 gene that encodes a putative novel zinc finger protein and its possible involvement in cellular seneseence显示文摘 | Shibanuma M Mashimo J Kuroki T Nose K | 1994 | J Biol Chem1994，269，26： | 1 |
| 4 | Local anaesthetics have different mechanisms and sites of action at the re-combinant N-methyl-D-aspartate(NMDA)receptors显示文摘 | Sugimoto M Uchida I Mashimo T | 2003 | Br J Pharmacol2003，138，： | 1 |
| 5 | The expression of the KAI1 gene,a tumor metastasis suppressor,is directly activated by p53显示文摘 | Mashimo T Waabe M Hirota S | 1998 | Proc Natl Acad Sci USA1998，95，11： | 1 |
| 6 | Effects of the oxidation pretreatment with hydrogen per oxide on the hydrogenolysis reactivity of coal liquefaction residue显示文摘 | Sugano M Ikemizu R Mashimo K | 2002 | Fuel Process Technol2002，，7778： | 1 |
| 7 | The effect of positive end-expiratory pressure and continuous positive airway pressure onthe oxygenation and shunt fraction during one-lung ventilationwith propofol anesthesia显示文摘 | Fujiwara M Abe K Mashimo T | 2001 | J Clin Anesth2001，13，7： | 1 |
| 8 | Evidence for the involvement of GABA a receptor blockade in convulsions induced by cephalospo- tins 显示文摘 | Sugimoto M Uchida I Mashimo T | 2003 | N europharmacology2003，45，3： | 1 |
| 9 | Application of a newly designed right-sided,double-lumen endobronchial tube in patients with a very short right mainstem bronchus显示文摘 | Hagihira S Takashina M Mashimo T | 2008 | Anesthesiology2008，109，3： | 1 |
| 10 | Evidence for the involvement of GABA (A) receptor blockade in convulsions induced by cephalosporius显示文摘 | Sugimoto M Uchida I Mashimo T | 2003 | Neuropharmacology2003，45，3： | 1 |
| 11 | Evidence for the involvement of GA-BA(A)receptor blockade in convulsions induced by cephalosp- orins 显示文摘 | Sugimoto M Uchida I Mashimo T | 2003 | Neuropharmacolopy2003，45，3： | 1 |
| 12 | Effect of Matrix's Type on the Dynamic Properties of or Short Fiber-elastomer Composite 显示文摘 | Ashida M Noguchi T Mashimo S | 1985 | Journal of Applied Polymer Science1985，30，： | 1 |
| 13 | Evidence for the involve - ment of GABA (A) receptor blockade in convulsions induced by cepha-losporius 显示文摘 | Sugimoto M Uchida I Mashimo T | 2003 | Neuropharmacology2003，45，3： | 1 |
| 14 | Evidence for the involvement of GABA(A) receptor blockade in convulsions in- duced by cephalosporins 显示文摘 | Sugimoto M Uchida I Mashimo T | 2003 | Neuropharmacology2003，45，3： | 1 |
| 15 | Effect of matrix's type on the dynamic' properties for short fiber elastomer composite显示文摘 | Ashida M NoguchiT Mashimo S | 1985 | Journal of Applied Polymer Science1985，30，3： | 1 |
| 16 | Cloning from amouse osteoblastic cell line of a set of transforming-growth-faotDr-beta lreguhted genes,one of which seems to encode afollistatin-related polypeptide 显示文摘 | Shibanuma M Mashimo J Mita A | 1993 | Eur J Biochem1993，217，： | 1 |
| 17 | The expression of the KAI1 gene,a tumor metastasis suppressor,is directly activated by P53显示文摘 | Mashimo T Watabe M Hirota S | 1998 | Proc Natl Acad Sci USA1998，95，19： | 1 |
| 18 | Rapid development of nitric oxide-induced hyperalgesia depends on an alternate to the cGMP-mediated pathway in the rat neuropathic pain model 显示文摘 | Inoue T Mashimo T Shibata M | 1998 | Brain Res1998，792，2： | 1 |
| 19 | Surveillance and screening for Barrett esophagus and adenocarcinoma显示文摘 | Mashimo H Wagh M S Goyal R K | 2005 | J Clin Gastroenterol2005，39，42： | 1 |
| 20 | The effect of positive end- expiratory pressure and continuous positive airway pressure on the oxygenation and shunt fraction during one-lung ventilation with propofol anesthesia显示文摘 | Fujiwara M Abe K Mashimo T | 2001 | J Clin Anesth2001，13，7： | 1 |
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