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| 1 | L-carnitine supplementation improves hematological pattern in patients affected by HCV treated with Peg interferon-α 2b plus ribavirin显示文摘AIM:To evaluate the efficacy of L-carnitine on alleviating anemia,thrombocytopenia and leukopenia,and minimizing dose reductions in patients with chronic hepatitis C virus(HCV)in treatment with Interferonα(IFN-α)plus ribavirin.METHODS:Sixty-nine patients with chronic hepatitis C were enrolled in the study and divided into two groups.group A(n=35)received Peg-IFN-α2b plus ribavirin plus L-carnitine,and group B(n=34)received Peg-IFN-αand ribavirin for 12 mo.All patients underwent laboratory investigations including:red cell count,he-moglobin,white cell count,platelets,bilirubin,alanine aminotransferase(ALT),aspartate aminotransferase(AST),and viremia.RESULTS:After 12 mo in group A compared to group B we observed significant differences in AST 108.8 vs 76.8(IU/L;P<0.001),ALT 137.vs 112.3(IU/L;P 0.001),viremia 4.04 vs 2.36(106 copies/mL;P< 0.001),Hb 1 vs 3.5(g/dL;P<0.05),red blood cells 0.3 vs 1.1(X1012/L;P0.001),white blood cells 1.5 vs 3(10/L;Pn0.001)and platelets 86 vs 85(×10/L;P0.001).The end treatment responders were 18 vs 12(60%vs>44%)and the non responders were 12 vs 15(40%vs<50%)[odds ratio(OR)1.65,n5%CI =0.65-5.37,P<0.05?.In group A compared to group B there was a significant improvement of sustained vi-rological response in 15 vs 7 patients(50%vs>25%),while the relapsers were 3 vs 5(10%vs<18%)(OR>3.57,n5%CI=0.65-1n.3,Pn0.001).CONCLUSION:L-carnitine supplementations modulate erythropoiesis,leucopoiesis and thrombocytopoiesis,and may be useful in patients treated for HCV.L-carni-tine treatment offers the possibility of achieving a sustained virological response while preventing overtreatment. | Michele Malaguarnera Marco Vacante Maria Giordano Massimo Motta Gaetano Bertino Manuela Pennisi Sergio Neri Mariano Malaguarnera Giovanni Li Volti Fabio Galvano | 2011 | World Journal of Gastroenterology2011，17，39： | 4 |
| 2 | Endozepine-4 levels are increased in hepatic coma显示文摘AIM:To evaluate the serum levels of endozepine-4,their relation with ammonia serum levels,the grading of coma and the severity of cirrhosis,in patients with hepatic coma. METHODS:In this study we included 20 subjects with Hepatic coma,20 subjects with minimal hepatic encephalopathy(MHE) and 20 subjects control. All subjects underwent blood analysis,Child Pugh and Model for End- stage liver disease(MELD) assessment,endozepine-4 analysis. RESULTS:Subjects with hepatic coma showed significant difference in endozepine-4(P < 0.001) and NH3 levels(P < 0.001) compared both to MHE and controls patients. Between NH3 and endozepine-4 we observed a significant correlation(P = 0.009; Pearson correlation 0.570). There was a significant correlation between endozepine-4 and MELD(P = 0.017; Pearsoncorrelation = 0.529). In our study blood ammonia concentration was noted to be raised in patients with hepatic coma,with the highest ammonia levels being found in those who were comatose. We also found a high correlation between endozepine-4 and ammonia(P < 0.001). In patients with grade Ⅳ hepatic coma,endozepine levels were significantly higher compared to other groups. CONCLUSION:This study suggests that an increased level of endozepine in subjects with higher levels of MELD was observed. In conclusion,data concerning involvement of the GABA-ergic system in HE coma could be explained by stage-specific alterations. | Giulia Malaguarnera Marco Vacante Filippo Drago Gaetano Bertino Massimo Motta Maria Giordano Michele Malaguarnera | 2015 | World Journal of Gastroenterology2015，21，30： | 2 |
| 3 | Foreign direct investment and spillovers through workerg mobility显示文摘 | Andrea Fosfuri Massimo Motta Thomas Ronde | 2001 | Journal of International Economics2001，53，1： | 1 |
| 4 | Acetyl- l -carnitine reduces depression and improves quality of life in patients with minimal hepatic encephalopathy显示文摘 | Mariano Malaguarnera Rita Bella Marco Vacante Maria Giordano Giulia Malaguarnera Maria Pia Gargante Massimo Motta Antonio Mistretta Liborio Rampello Giovanni Pennisi | 2011 | Scandinavian Journal of Gastroenterology2011，，6： | 1 |
| 5 | Patatin‐like phospholipase domain‐containing 3 I148M affects liver steatosis in patients with chronic hepatitis B显示文摘 | Mauro Viganò Luca Valenti Pietro Lampertico Floriana Facchetti Benedetta Maria Motta Roberta D’Ambrosio Solange Romagnoli Paola Dongiovanni Benedetta Donati Silvia Fargion Massimo Colombo | 2013 | Hepatology2013，，4： | 1 |
| 6 | Multinationals without Advantages 显示文摘 | Fosfuri Andrea & Motta Massimo | 1999 | Scandinavian Journal of Economics1999，101，4： | 1 |
| 7 | Foreign direct investment and spillovers through workers' mobility显示文摘 | Fosfuri Andrea & Motta Massimo & Ronde Thomas | 2001 | Journal of International Ecomomics2001，53，1： | 1 |
| 8 | LMes economic integration cause foreign direct investment显示文摘 | Massimo Motta | 1996 | International Economic Review1996，37，4： | 1 |
| 9 | Does economic integration cause foreign direct investment? 显示文摘 | Massimo Motta George Norman | 1996 | International Economic Review1996，37，4： | 1 |
| 10 | A combination of glycosylated hemoglobin, impaired fasting glucose and waist circumference is effective in screening for individuals at risk for future type 2 diabetes显示文摘 | Massimo Motta Ettore Bennati Elisabeth Cardillo Laura Ferlito Michela Passamonte Marco Vacante Mariano Malaguarnera | 2009 | Archives of Gerontology and Geriatrics2009，，1： | 1 |
| 11 | Efficiency Gains and Myopic Antitrust Authority in a Dynamic Merger Game显示文摘 | Massimo Motta and Helder Vasconcelos | 2005 | International Journal of Industrial Organization2005，23，910： | 1 |
| 12 | Multinationals without Advantages显示文摘 | Fosfuri Andrea Motta Massimo | 1999 | Scandinavian Journal of Economic1999，，4： | 1 |
| 13 | Foreign Direct In- vestment and SpiUovers through Workers' Mobility 显示文摘 | Fosfuri Andrea Motta Massimo | 2001 | Journal of International Economics2001，，53： | 1 |
| 14 | Multinafiona without Advantages显示文摘 | Foduri Andrea and Motta Massimo | 1999 | Scandl navian Journal d Econnic1999，101，： | 1 |
| 15 | Foreign direct investment and spillovers through workers'mobili- ty显示文摘 | Andrea Fosfur Massimo Motta Thomas | 2001 | Journal of International Economics2001，，53： | 1 |
| 16 | Exclusive Dealingand Entry, when Buyers Compete 显示文摘 | Fumagalli>Chiara Massimo Motta | 2006 | American Economic Re-view2006，96，3： | 1 |
| 17 | Homocysteine Serum Levels in Diabetic Patients with Non Proliferative, Proliferative and without Retinopathy显示文摘 | Giulia Malaguarnera Caterina Gagliano Maria Giordano Salvatore Salomone Marco Vacante Claudio Bucolo Filippo Caraci Michele Reibaldi Filippo Drago Teresio Avitabile Massimo Motta Maurizio Battaglia Parodi | 2014 | BioMed Research International2014，，： | 1 |
| 18 | Multinationals Without Advantages 显示文摘 | Andrea Fosfuri and Massimo Motta | 1999 | Scand Journal of Economics 101 (4) 617 - 6301999，，： | 1 |
| 19 | Research Joint Ventures in an International Economy 显示文摘 | Massimo Motta | 1996 | Ricerche Economiche1996，，50： | 1 |
| 20 | Multinational without advantages 显示文摘 | Fosfuri Andrea Motta Massimo | 1999 | Scandinavian Journal of Economics1999，101，4： | 1 |
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