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| 1 | PrP^C-related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site显示文摘铜绑定,抛锚膜的、细胞的 prion 蛋白质(PrPC ) 有二个组成的劈开地点生产不同 N 终端和 C 终端碎片(N1/C1 和 N2/C2 ) 。用表示也人的 PrPC,鼠标 PrPC 或鼠标 PrPC 的 RK13 房间带 3F4 epitope,这研究在 endoproteolytic 劈开和一个通常认为的 PrPC 函数上探索了 PrPC 主要顺序的影响,地图 kinase 信号 transduction,响应外长的铜与或没有使不安的膜环境。PrPC 主要顺序,特别在 N1/C1 劈开地点附近,看起来在这个地点和细胞外的调整信号的 kinase 1/2 (ERK1/2 ) phosphorylation 影响解朊作用的基础层次,与处理激活增加与基础 ERK1/2 表明一种反的关系。人的 PrPC 独自响应铜显示出增加的 N1/C1 劈开,由特定的 p38 和 JNK/SAPK phosphorylation 伴随了。到加扣押胆固醇的抗菌素 filipin 的铜的联合暴露导致了一只老鼠信号蛋白质 phosphorylation 的 PrPC 特定的实质的增加,由 N1/C1 劈开的增加伴随了。怀有人的 N1/C1 劈开地点的老鼠 PrPC 基础地并且响应铜假定更似人类的侧面并且改变了膜环境。我们的结果证明在 N1/C1 劈开地点附近的 PrPC 主要顺序影响在这个地点处理的 endoproteolytic,它显得连接了基础地并且响应铜印射 kinase 信号 transduction。进一步,主要顺序看起来响应外长的刺激在 PrPC 相关的信号 transduction 的忠实上授与 N1/C1 劈开和膜完整的相互的依赖。 | Cathryn L Haigh | 2009 | Cell Research2009，19，9： | 4 |
| 2 | Deep basin gas traps, Western Canada显示文摘 | | 1979 | AAPG Bulletin1979，34，2： | 1 |
| 3 | Motor Learning of a Dynamic Balancing Task After Stroke:Implicit Implications for Stroke Rehabilitation显示文摘 | Alison J Otrell Frank F Eves Rich S W Masters | 2006 | Physical Theropy2006，3，86： | 1 |
| 4 | Subsurface issues for COz flooding of UKCS reservoirs显示文摘 | Goodyear S G Hawkyard I R Masters J H K | 2003 | Chemical engineering research and design2003，81，3： | 1 |
| 5 | Iron control in zinc pressure leach process显示文摘 | K R Buban M J Collins I M Masters | 1999 | JOM1999，51，12： | 1 |
| 6 | Stable implicit motor processes despite aerobic locomotor fatigue显示文摘 | MASTERS R S W POOLTON J M MAXWELL J P | 2008 | Consciousness and cogni- tion2008，17，： | 1 |
| 7 | Identification, Sequencing targeted mutagenesis, and expression of a recA gene required for the extreme radio resistance of Deinococcus radiodurans 显示文摘 | Gutman P D Carroll J D Masters C L | 1994 | Gene1994，141，1： | 1 |
| 8 | Statistical evaluation of voltages in distrib:ution systems with embedded wind generation显示文摘 | MASTERS C L MUTALE J STRBAC G | 2000 | Proceedings of IEE2000，147，4： | 1 |
| 9 | Most Fre- quently Used Heat Exchangers From Pioneering Research to Worldwide Applications 显示文摘 | Master B I Chunangad K S Boxma A J | 2006 | Heat Transfer Engineering2006，27，6： | 1 |
| 10 | Why you should consider object-oriented programming techniques for finite element methods 显示文摘 | Cross J T Masters I Lewis R W | 1999 | International Journal of Numerical Methods for Heat & Fluid Flow1999，9，3： | 1 |
| 11 | Mechanical properties of triaxially braided composites: experimental and analytical results 显示文摘 | Masters J E Foye R L Pastore C M | 1993 | J Compo Technol Res1993，15，2： | 1 |
| 12 | Lightning in dueed voltages on power lines显示文摘 | Master M J Uman M A Beasley W H | 1984 | IEEE Trans PAS1984，103，： | 1 |
| 13 | Deep basin gas trap, Western Canada 显示文摘 | MASTERS J A | 1979 | AAPG Bulletin1979，63，2： | 1 |
| 14 | A novel receptor for Apo2L/TRAIL contains a truncated death domain显示文摘 | Masters S A Sheridan J P Pitti R M | | 0，，： | 1 |
| 15 | The structure and coherence of competence from childhood through adolescence 显示文摘 | Masters AS Coatsworth JD Neemann J | 1995 | Child Development1995，66，： | 1 |
| 16 | Systematic literature review of oral hygiene practiees for intensive eare patients receiv- ing mechanical ventilation显示文摘 | Berry AM Davidson PM Masters J | 2007 | Am J Crit Care2007，16，6： | 1 |
| 17 | A role for survivin in chemoresistance ofendothelial cells mediated by VEGF显示文摘 | Tran J Master Z Yu J L | 2002 | Proc Natl Acad Sci USA2002，99，7： | 1 |
| 18 | Systematic literature review of oral hygiene practices for intensive care patients receiv- ing mechanical ventilation显示文摘 | Berry AM Davidson PM Masters J | 2007 | Am J Crit Care2007，16，6： | 1 |
| 19 | The Implicit Benefit of Learning Without Errors显示文摘 | Maxwell J P Masters R S W Kerr E Weedon E | 2001 | Quarterly Journal of Experimental Psychology2001，54，4： | 1 |
| 20 | Effect of fiber architecture parameters on deformation field and elastic moduli of 2-Dbraided composite 显示文摘 | Naik R A Ifju P G Masters J E | 1994 | Journal of Composite Materials1994，28，7： | 1 |
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