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| 1 | interrelationships between ghrelin, insulin and glucose homeostasis: physiological relevance显示文摘Ghrelin is a 28 amino acid peptide mainly derived from the oxyntic gland of the stomach. Both acylated(AG) and unacylated(UAG) forms of ghrelin are found in the circulation. Initially, AG was considered as the only bioactive form of ghrelin. However, recent advances indicate that both AG and UAG exert distinct and common effects in organisms. Soon after its discovery, ghrelin was shown to promote appetite and adiposity in animal and human models. In response to these anabolic effects, an impressive number of elements have suggested the influence of ghrelin on the regulation of metabolic functions and the development of obesityrelated disorders. However, due to the complexity ofits biochemical nature and the physiological processes it governs, some of the effects of ghrelin are still debated in the literature. Evidence suggests that ghrelin influences glucose homeostasis through the modulation of insulin secretion and insulin receptor signaling. On the other hand, insulin was also shown to influence circulating levels of ghrelin. Here, we review the relationship between ghrelin and insulin and we describe the impact of this interaction on the modulation of glucose homeostasis. | FranCois Chabot Alexandre Caron Mathieu Laplante David H St-Pierre | 2014 | World Journal of Diabetes2014，5，3： | 9 |
| 2 | mTOR Signaling in Growth Control and Disease显示文摘 | Mathieu Laplante David M. Sabatini | 2012 | Cell2012，，2： | 7 |
| 3 | DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival显示文摘 | Timothy R. Peterson Mathieu Laplante Carson C. Thoreen Yasemin Sancak Seong A. Kang W. Michael Kuehl Nathanael S. Gray David M. Sabatini | 2009 | Cell2009，，5： | 2 |
| 4 | sabatini, mTOR signaling in growth control and disease显示文摘 | Mathieu Laplante David M | 2012 | Cell2012，149，2： | 1 |
| 5 | mTOR Signaling in Growth Control and Disease显示文摘 | Mathieu Laplante David M. Sabatini | 2012 | Cell2012，，2： | 1 |
| 6 | mTOR Signaling in Growth Control and Disease显示文摘 | Mathieu Laplante David M. Sabatini | 2012 | Cell2012，，2： | 1 |
| 7 | An Emerging Role of mTOR in Lipid Biosynthesis显示文摘 | Mathieu Laplante David M. Sabatini | 2009 | Current Biology2009，，22： | 1 |
| 8 | mTOR signaling at a glance显示文摘 | Mathieu Laplante David M Sabatini | 2009 | Cell Sci2009，122，20： | 1 |
| 9 | DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival显示文摘 | Timothy R. Peterson Mathieu Laplante Carson C. Thoreen Yasemin Sancak Seong A. Kang W. Michael Kuehl Nathanael S. Gray David M. Sabatini | 2009 | Cell2009，，5： | 1 |
| 10 | Sabatini,Molecular mechanisms of mTOR-mediated translational control显示文摘 | Mathieu Laplante David M | 2009 | Journal of Cell Science2009，122，20： | 1 |
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