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| 1 | Phonon imaging in 3D with a fibre probe显示文摘We show for the first time that a single ultrasonic imaging fibre is capable of simultaneously accessing 3D spatial information and mechanical properties from microscopic objects.The novel measurement system consists of two ultrafast lasers that excite and detect high-frequency ultrasound from a nano-transducer that was fabricated onto the tip of a single-mode optical fibre.A signal processing technique was also developed to extract nanometric in-depth spatial measurements from GHz frequency acoustic waves,while still allowing Brillouin spectroscopy in the frequency domain.Label-free and non-contact imaging performance was demonstrated on various polymer microstructures.This singular device is equipped with optical lateral resolution,2.5μm,and a depth-profiling precision of 45 nm provided by acoustics.The endoscopic potential for this device is exhibited by extrapolating the single fibre to tens of thousands of fibres in an imaging bundle.Such a device catalyses future phonon endomicroscopy technology that brings the prospect of label-free in vivo histology within reach. | Salvatore La Cavera III Fernando Perez-Cota Richard JSmith Matt Clark | 2021 | Light(Science & Applications)2021，10，6： | 2 |
| 2 | First principles methods using CASTEP显示文摘 | Stewart J. Clark Matthew D. Segall Chris J. Pickard Phil J. Hasnip Matt I. J. Probert Keith Refson Mike C. Payne | 2005 | Zeitschrift für Kristallographie . 2005 (5/6/)2005，，5： | 1 |
| 3 | A comparison of GPS, VLBI and model estimates of ocean tide loading displacements显示文摘 | Ian D. Thomas Matt A. King Peter J. Clarke | 2007 | Journal of Geodesy2007，，5： | 1 |
| 4 | Understanding Interaction Models:Improving Empirical Analyses显示文摘 | Thomas Brambor William Roberts Clark Matt Golder | | 0，，： | 1 |
| 5 | A comparison of GPS, VLBI and model estimates of ocean tide loading displacements显示文摘 | Ian D. Thomas Matt A. King Peter J. Clarke | 2007 | Journal of Geodesy2007，，5： | 1 |
| 6 | Density functional theory in the solid state显示文摘 | Philip J. Hasnip Keith Refson Matt I. J. Probert Jonathan R. Yates Stewart J. Clark Chris J. Pickard | 2014 | Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences . 2014 (2011)2014，，2011： | 1 |
| 7 | Developing a coordinate-based strategy to support cognitive targeted prostate biopsies and correlative spatial-histopathological outcome analysis显示文摘Lack of investment for magnetic resonance(MR)fusion systems is an obstacle to deliver targeted prostate biopsies within the prostate cancer diagnostic pathway.We developed a coordinate-based method to support cognitive targeted prostate biopsies and then performed an audit on cancer detection and the location of lesions.In each patient,the prostate is considered as two separate hemiprostates,and each hemiprostate is divided into 4×4×4 units.Each unit is therefore defined by a three-dimensional coordinate.We prospectively applied our coordinates approach to target 106 prostatic lesions in 93 men.Among 45(of 106;42.5%)lesions positive for cancer,27 lesions(60.0%)harbored clinically significant disease.PSA density was significantly higher in patients with proven cancer(median:0.264 ng ml^(-2))when compared to the noncancer group(median:0.145 ng ml-2;P=0.003,Wilcoxon ranksum test).Lesions with Prostate Imaging-Reporting and Data System(PIRADS)score of 5 were found to have a cancer incidence of 65.2%,while PI RADS 4 and 3 lesions have a lower risk of cancer detection,as expected,at 37.3%and 31.3%,respectively.The probability of a lesion being cancerous in our series significantly decreases as we go from the“apex-to-base”dimension(odds ratio[OR]:2.62,95%confidence interval[Cl]:1.55-4.44,P=0.00034).Our analysis also indicates that the probability of cancer decreases as the prostate volume increases(OR:1.03,95%Cl:1.01-1.05,P=0.00327).Based on this feasibility study,the use of coordinates to guide cognitive targeted prostate biopsies warrants future validation study in additional centers. | Keiran D Clement Lizzy Day Helen Rooney Matt Neilson Fiona Birrell Mark Salji Elizabeth Norm an Ross Clark Amit Patel John Morrison Hing Y Leung | 2021 | Asian Journal of Andrology2021，23，3： | 0 |
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