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| 1 | Engineering Microneedle Patches for Improved Penetration:Analysis,Skin Models and Factors Affecting Needle Insertion显示文摘Transdermal microneedle(MN)patches are a promising tool used to transport a wide variety of active compounds into the skin.To serve as a substitute for common hypodermic needles,MNs must pierce the human stratum corneum(~10 to 20μm),without rupturing or bending during penetration.This ensures that the cargo is released at the predetermined place and time.Therefore,the ability of MN patches to sufficiently pierce the skin is a crucial requirement.In the current review,the pain signal and its management during application of MNs and typical hypodermic needles are presented and compared.This is followed by a discussion on mechanical analysis and skin models used for insertion tests before application to clinical practice.Factors that affect insertion(e.g.,geometry,material composition and cross-linking of MNs),along with recent advancements in developed strategies(e.g.,insertion responsive patches and 3D printed biomimetic MNs using two-photon lithography)to improve the skin penetration are highlighted to provide a backdrop for future research. | Pooyan Makvandi Melissa Kirkby Aaron RJHutton Majid Shabani Cynthia K.Y.Yiu Zahra Baghbantaraghdari Rezvan Jamaledin Marco Carlotti Barbara Mazzolai Virgilio Mattoli Ryan F.Donnelly | 2021 | Nano-Micro Letters2021，13，6： | 5 |
| 2 | 血源性成纤维细胞在哮喘发病机制和预后中的作用(英文)显示文摘血源性成纤维细胞来自骨髓,可表达一些通常造血祖细胞属性的表面抗原,同时有和未成熟间质细胞相似的表型和功能特征。依据机体对环境刺激的反应和局部浸润的细胞类型及不同的细胞因子环境,血源性成纤维细胞可局部组织显示强烈的促炎症活性或促纤维化活性。过敏性哮喘患者每次遭受过敏原暴露或病毒感染时,成纤维细胞即从骨髓中迁出并被募集至气道组织;而募集的成纤维细胞可放大由Th2细胞因子驱使的炎症反应,并有利于病毒的复制,进一步加重病毒感染引发的炎症。在未治疗的慢性哮喘和激素不敏感的哮喘患者中可观察到持续性外周血成纤维细胞计数升高及气道纤维细胞浸润,而这和不良预后的风险增加有关。究其原因,成纤维细胞主要涉及气道结构异常的进展,而后者导致患者慢性气流受限。因此,外周血成纤维细胞计数是一种新发现的哮喘控制和疾病预后的生物学标记,作为一种新的结果检测方法,它的临床应用还需要大样本临床研究去评估。 | Sabrina MATTOLI | 2015 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2015，16，8： | 2 |
| 3 | The role of the fibrocyte,a bone marrow-derived mesenchymal progenitor,in reactive and reparative fibroses显示文摘 | Bellini A Mattoli S | | 0，，09： | 1 |
| 4 | Eotaxin expression andeosinophilic inflammation in asthma显示文摘 | Mattoli S Stacey MA Sun G | 1997 | Biochem Biophys Res Commun1997，，2： | 1 |
| 5 | Expression of the potent inflammatory cytokines, GM-CSF, IL6, and IL8, in bron- chial epithelial cells of asthmatic patients 显示文摘 | Mattoli S Marini M Fasoli A | 1992 | Chest1992，101，3： | 1 |
| 6 | Tumor necrosis factor genetic polymo rphisms correlate with infections after liver transplantation显示文摘 | Freeman RBJ Tran CL Mattoli J | | 0，，： | 1 |
| 7 | Eotaxin expression and eosinophilic inflammation in asthma显示文摘 | Mattoli S Stacey MA Sun G | 1997 | Biochem Biophys Res Commun1997，236，： | 1 |
| 8 | lelluar and biochemieal charactertics of bronchoalveolar lavage fluid in symptomatic nonallergie asthma显示文摘 | Mattoli S Mattosos VL Solopertq M | 1991 | J Allrgy Clin Immunol1991，87，4： | 1 |
| 9 | Celluar and biochemieal charactertics of bronchoalveolar lavage lluid in symptomatic nonallergie asthma显示文摘 | Mattoli S Mattoso VL Soloperto M | 1991 | J Allergy Clin Immunol1991，87，4： | 1 |
| 10 | 显示文摘 | Am J Respir FASEB J 2001 15 Bellini A Mattoli S | 2007 | Lab Invest2007，87，9： | 1 |
| 11 | Eotaxin expression and eosinophilic inflammation in asthma显示文摘 | Mattoli S Stacey MA Sun G | 1997 | Biochem Biophys Res Commun1997，236，2： | 1 |
| 12 | Eotaxin expression and eo- sinophilic inflammation in asthma 显示文摘 | Mattoli S Staoev MA Sun G | 1997 | Biochem Biophys Res Commnn1997，236，： | 1 |
| 13 | Eotaxin expression and eosinophilic inflammation in asthma 显示文摘 | Mattoli S Stacey M A Sun G | 1997 | Biochem Biophys Res Commun1997，236，2： | 1 |
| 14 | The role of the fibrocyte, a bone marrowderived mesenchymal progenitor, in reactive and reparative fibroses显示文摘 | Bellini A Mattoli S | 2007 | Lab Invest2007，87，9： | 1 |
| 15 | Specific binding of endothelin on human bronchial smooth muscle cells in culcure and section of endothelin-like material from bronchial显示文摘 | Mattoli S Mezzetti M Riva G | 1990 | Am J Respir Cell Mol Biol1990，3，1： | 1 |
| 16 | The role of the fibrocyte, a bone marrow-derived mesenchymal progenitor, in reactive and reparative fibroses显示文摘 | Bellini A Mattoli S | 2007 | Lab Invest2007，87，9： | 1 |
| 17 | A universal intelli- gent system-on-chip based sensor interface显示文摘 | Mattoli V Mondini A Mazzolai B | 2010 | Sensors2010，，10： | 1 |
| 18 | The role of CD8^+ Th2 lymphocytes in the development of smokingrelated lung damage显示文摘 | Mattoli S Kleimberg J Stacey MA | 1997 | Biochemi Biophys Res Commun1997，239，1： | 1 |
| 19 | Stemness characteristics and osteogenic potential of sheep amniotic epithelial cells显示文摘 | Mattoli M Gloria A Turriani M | 2012 | Cell Biol Int2012，36，1： | 1 |
| 20 | The role of the fibrocyte, a bone marrow- derived mesenchymal progenitor,in reactive and reparative fi- hroses显示文摘 | Bellini A Mattoli S | 2007 | Lab lnvest2007，87，85： | 1 |
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