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| 1 | Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?显示文摘AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects. | Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 2 | Emptying of the jejunal pouch and roux-en-Y limb after total gastrectomy-a randomised,prospective study显示文摘 | Mauri K Iivonen Matti O | 1999 | Eur J Surg1999，165，8： | 1 |
| 3 | Receiver-operating characteristic analysis for evaluating diagnostic tests and predictive models 显示文摘 | Zou K H O'Malley A J Mauri L | 2007 | Circulation2007，115，5： | 1 |
| 4 | Receiver-operating characteristic analysis for evaluating diagnostic tests and predictive models显示文摘 | Zou KH O′Malley AJ Mauri L | 2007 | Circulation2007，115，65： | 1 |
| 5 | Effects of stent length and lesion length on coronary restenosis显示文摘 | Mauri L O'Malley AJ Curlip DE | 2004 | Am J Cardiol2004，93，1： | 1 |
| 6 | Patterned, hybrid, multilayer nanostructures based on mul- tivalent supramolecular interactions显示文摘 | CRESPO-BIEL O DORDI B MAURY P | 2006 | Chemistry of Mate- rials2006，18，10： | 1 |
| 7 | Hierarchical interpretation of nonlinear relationships linking yellowfin tuna (Thunnus lbacares) distribution to the environment in the Atlantic Ocean显示文摘 | Maury O Gascuel D Marsac F | 2001 | Canadian Journal of Fisheries and Aquatic Sciences2001，58，3： | 1 |
| 8 | Valvular heart disease in the pregnant patient显示文摘 | MAURI L O'GARA P T | 2001 | Curr Treat Options Cardiovasc Med2001，3，1： | 1 |
| 9 | Comparison of thrombosis and restenosis risk from stent length of sirolimus-eluting stents versus bare metal stents 显示文摘 | Mauri L O' Malley A J Popma JJ | 2005 | Am J Cardiol2005，95，10： | 1 |
| 10 | Cardioangio immunology:the im-mune implications in the principle cardiovascular pathologies显示文摘 | Lissoni P Barni S Mauri O | 1991 | G Ital Cardiol1991，21，10： | 1 |
| 11 | Risk of fracture in celiac disease:Gender,dietary compliance,or both?显示文摘AIM:To determine the incidence of peripheral fractures in patients with celiac disease (CD) and the effect of treatment on fracture risk.METHODS:We compared the incidence and risk of peripheral fractures before and after diagnosis between a cohort of 265 patients who had been diagnosed with CD at least 5 years before study entry and a cohort of 530 age-and sex-matched controls who had been diagnosed with functional gastrointestinal disorders.Data were collected through in-person interviews with an investigator.The overall assessment window for patients was 9843 patient-years (2815 patient-years after diagnosis).RESULTS:Compared with the control group,the CD cohort showed significantly higher incidence rate and risk of first peripheral fracture before diagnosis [adjusted hazard ratio (HR):1.78,95% CI:1.23-2.56,P < 0.002] and in men (HR:2.67,95% CI:1.37-5.22,P < 0.004).Fracture risk was significantly associated with the classic CD presentation with gastrointestinal symptoms (P < 0.003).In the time period after diagnosis,the risk of fractures was comparable between the CD cohort and controls in both sexes (HR:1.08,95% CI:0.55-2.10 for women;HR:1.57,95% CI:0.57-4.26 for men).CONCLUSION:CD patients have higher prevalence of fractures in the peripheral skeleton before diagnosis.This is associated with male sex and classic clinical presentation.The fracture risk was reduced after the treatment. | María Inés Pinto Sánchez Adriana Mohaidle Andrea Baistrocchi Dolores Matoso Horacio Vázquez Andrea González Roberto Mazure Evangelina Maffei Guillermina Ferrari Edgardo Smecuol Adriana Crivelli Juan Andrés de Paula Juan C Gómez Silvia Pedreira Eduardo Maurio Julio César Bai | 2011 | World Journal of Gastroenterology2011，17，25： | 1 |
| 12 | Receiver-operating characteristic analysis for evaluating diagnostic tests and predictive models 显示文摘 | Zou KH O' Malley AJ Mauri L | 2007 | Circulation2007，115，5： | 1 |
| 13 | Gluten immunogenic peptide excretion detects dietary transgressions in treated celiac disease patients显示文摘BACKGROUND Life-long removal of gluten from the diet is currently the only way to manage celiac disease(CeD). Until now, no objective test has proven useful to objectively detect ingested gluten in clinical practice. Recently, tests that determine consumption of gluten by assessing excretion of gluten immunogenic peptides(GIP) in stool and urine have been developed. Their utility, in comparison with conventional dietary and analytical follow-up strategies, has not been fully established.AIM To assess the performance of enzyme-linked immunosorbent assay(ELISA) and point-of-care tests(PoCTs) for GIP excretion in CeD patients on gluten-free diet(GFD).METHODS We conducted an observational, prospective, cross-sectional study in patients following a GFD for at least two years. Using the Gastrointestinal Symptom Rating Scale questionnaire, patients were classified at enrollment as asymptomatic or symptomatic. Gluten consumption was assessed twice by 3-d dietary recall and GIP excretion(by ELISA in stool and PoCTs(commercial kits for stool and urine) in two consecutive samples. These samples and dietary reports were obtained 10 day apart one from the other. Patients were encouraged to follow their usual GFD during the study period.RESULTS Forty-four patients were enrolled, of which 19(43.2%) were symptomatic despite being on a GFD. Overall, 83 sets of stool and/or urine samples were collected.Eleven out of 44 patients(25.0%) had at least one positive GIP test. The occurrence of at least one positive test was 32% in asymptomatic patients compared with 15.8% in symptomatic patients. GIP was concordant with dietary reports in 65.9% of cases(Cohen′s kappa: 0.317). PoCT detected dietary indiscretions. Both ELISA and PoCT in stool were concordant(concomitantly positive or negative) in 67 out of 74(90.5%) samples. Excretion of GIP was detected in 7(8.4%) stool and/or urine samples from patients considered to be strictly compliant with the GFD by dietary reports.CONCLUSION GIP detects dietary transgressions in patients on long-term GFD, irrespective of the presence of symptoms. PoCT for GIP detection constitutes a simple homebased method for self-assessment of dietary indiscretions. | Ana Florencia Costa Emilia Sugai María de la Paz Temprano Sonia Isabel Niveloni Horacio Vázquez María Laura Moreno M.Remedios Domínguez-Flores Alba Mu?oz-Suano Edgardo Smecuol Juan Pablo Stefanolo Andrea F González Angel Cebolla-Ramirez Eduardo Mauri?o Elena F Verdú Julio César Bai | 2019 | World Journal of Gastroenterology2019，25，11： | 1 |
| 14 | Molecular engineering of octupolar NLO molecules and materials based on bipyridyl metal complexes显示文摘 | Maury O Le B H | | 0，，9： | 1 |
| 15 | Low pregnancy rate is achieved in patients treated with intracytoplasma sperm injection due to previous low or failed fertilization in in vitro fertilization显示文摘 | Candido T Mauri O Leena T | 1998 | Hum Reprod1998，13，： | 1 |
| 16 | Cardioangioimmunology:the immune implications in the principle cardiovascular pathologies显示文摘 | Lissoni P Barni S Mauri O | 1991 | G Ital Cardiol1991，21，10： | 1 |
| 17 | Effects of stent length and lesion length on coronary restenosis显示文摘 | Mauri L O'Malley AJ Cutlip DE | 2004 | Am J Cardiol2004，93，11： | 1 |
| 18 | Exocrine pancreatic insufficiency in celiac disease显示文摘 | Juan C. Gomez Carlos E. Morán Eduardo C. Mauri?o Julio C. Bai | 1998 | Gastroenterology1998，，3： | 1 |
| 19 | Low pregnancy rate is achieved in patients treated with intracytoplasma sperm injection due to previous low or failed fertilization in in vitro fertilization显示文摘 | Candido T Mauri O Leena T | 1998 | Hum Reprod1998，13，1： | 1 |
| 20 | Predictive (un) distortion model and 3-D reconstruction by biplane snakes显示文摘 | Vilari(n)o F Mauri J | 2002 | IEEE Transactions on Medical Imaging2002，21，9： | 1 |
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