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| 1 | RANK-ligand and osteoprotegerin as biomarkers in the differentiation between periprosthetic joint infection and aseptic prosthesis loosening显示文摘AIM To assess serum levels of RANK-ligand(RANKL) and osteoprotegerin(OPG) as biomarkers for periprosthetic joint infection(PJI) and compare their accuracy with standard tests.METHODS One hundred and twenty patients presenting with a painful total knee or hip arthroplasty with indication for surgical revision were included in this prospective clinical trial. Based on standard diagnostics(joint aspirate, microbiological, and histological samples) and Musculoskeletal Infection Society consensus classification,patients were categorized into PJI, aseptic loosening,and control groups. Implant loosening was assessed radiographically and intraoperatively. Preoperative serum samples were collected and analyzed for RANKL, OPG, calcium, phosphate, alkaline phosphatase(AP), and the bone-specific subform of AP(b AP). Statistical analysis was carried out, testing for significant differences between the three groups and between stable and loose implants. RESULTS All three groups were identical in regards to age, gender, and joint distribution. No statistically significant differences in the serum concentration of RANKL(P = 0.16) and OPG(P = 0.45) were found between aseptic loosening and PJI, with a trend towards lower RANKL concentrations and higher OPG concentrations in the PJI group. The RANKL/OPG ratio was significant for the comparison between PJI and non-PJI(P = 0.005). A ratio > 60 ruled out PJI in all cases(specificity: 100%, 95%CI: 89, 11% to 100.0%) but only 30% of non-PJI patients crossed this threshold. The positive predictive value remained poor at any cut-off. In the differentiation between stable and loose implants, none of the parameters measured(calcium, phosphate, AP, and b AP) showed a significant difference, and only AP and b AP measurements showed a tendency towards higher values in the loosened group(with P = 0.09 for AP and P = 0.19 for b AP). CONCLUSION Lower RANKL and higher OPG concentrations could be detected in PJI, without statistical significance. | Max J Friedrich Matthias D Wimmer Jan Schmolders Andreas C Strauss Milena M Ploeger Hendrik Kohlhof Dieter C Wirtz Sascha Gravius Thomas M Randau | 2017 | World Journal of Orthopedics2017，8，4： | 4 |
| 2 | Expression of CD4 on Epstein-Barr virus-immortalized B cells显示文摘 | Hoennscheidt C Max D Richter N | 2009 | Scand J lmmunol2009，70，3： | 1 |
| 3 | Downregulation of TGF - β1, β2, β3, and TGF - β receptor Ⅱ expression in human corneal fibreblasts by amniotic membrane 显示文摘 | TSENG S C G LI D Q MAX | 1998 | Invest Ophthalmol Vis Sci1998，39，： | 1 |
| 4 | Sea floor methane blow-out and global firestorm at the K-T boundary 显示文摘 | Max M D Dillon W P Nishimura C Hurdle B G | 1999 | Geo-Marine Letters1999，18，： | 1 |
| 5 | Magnetic-polarization effect of Pd layers in Fe/Pd multilayers显示文摘 | LI M MAX D PENG C B | 1994 | Physical Review B1994，50，10： | 1 |
| 6 | ,Battery energy storage technologies 显示文摘 | Max D A Dodd S C | 1993 | Proceedings ofthelEEE1993，81，3： | 1 |
| 7 | Au- tographa califomica nuclear polyhedrosis virus: subcellu- lar localization and protein trafficking of BV/ODV-E26 tointranuclear membranes and viral envelopes 显示文摘 | Hideo Beniya Sharon C Braunagel Max D Summers | 1998 | Virol1998，240，： | 1 |
| 8 | Is the ferric hydroperoxy species responsible for sulfur oxidation in cytochrome P450s显示文摘 | Max J C James J D V | | 0，，48： | 1 |
| 9 | Fuel options for the fuel cell vehicle: Hydrogen, methanol or ga- soline? 显示文摘 | Thomas C E James B D Lo - max Jr F D | 2000 | International Journal of Hydrogen En- ergy2000，，25： | 1 |
| 10 | Is there a better source of huperzine A than Huperzia serrata? Huperzine A content of Huperziaceae species in China显示文摘 | MAX Q TAN C H ZHU D Y | 2005 | Journal of Agricultural and Food Chemistry2005，53，： | 1 |
| 11 | A matched lesion analysisof childhood versus adult-onset brain injury due to unilat-eral stroke:another perspective on neural plasticity andrecovery of social functioning显示文摘 | Mosch S C Max J E Tranel D | 2005 | Cognitive and behav-ioural neurology2005，18，： | 1 |
| 12 | Effect of soybean plant populations in a soybean and maize rotation显示文摘 | Stella A E Max D C | 2001 | Agronomy Journal2001，93，： | 1 |
| 13 | Two-Phase Flow Patterns and Transition Characteristics for in-Tube Con- densation With Different Surface Inclinations 显示文摘 | WANG W C MAX H WEI Z D | 1998 | Interna- tional Journal of Heat and Mass Transfer1998，41，24： | 1 |
| 14 | Sliding wear behavior of copper-graphite composite material for use in maglev transportation system 显示文摘 | MAX C HE GQ HE D H | 2008 | Wear2008，265，： | 1 |
| 15 | Sliding wear behavior of copper-graphite composite material for use in maglev transportation system 显示文摘 | MAX C HE G Q HE D H | 2008 | Wear2008，265，： | 1 |
| 16 | Five-year follow-up of a prospective non-randomised study comparing duodenum-preserving pancreatic head resection with classic Whipple procedure in the treatment of chronic pancreatitis显示文摘 | Mobius C Max D Uhlmann D | 2007 | Langenbecks Arch Surg2007，392，3： | 1 |
| 17 | A survery of potentialhuperzine A natural resources in China : The Huperziaceae 显示文摘 | MaX Q Tan C H Zhu D Y | 2006 | J Ethnopharmacol2006，104，12： | 1 |
| 18 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences显示文摘 | STRAUSBERG R L FEINGOLD E A GROUSE L H DERGE J G KLAUSNER R D COLLINS F S WAGNER L SHENMEN C M SCHULER G D ALTSCHUL S F ZEEBERG B BUETOW K H SCHAEFER C F BHAT N K HOPKINS R F JORDAN H MOORE T MAX S I WANG J HSIEH F DIATCHENKO L MARUSINAK FARMER A A RUBIN G M HONG L STAPLETON M SOARES M B BONALDO M F CASAVANT T L SCHEETZ T E BROWNSTEIN M J USDIN T B TOSHIYUKI S CARNINCI P PRANGE C RAHA S S LOQUELLANO N A PETERS G J ABRAMSON R D MULLAHY S J BOSAK S A MCEWAN P J MCKERNAN K J MALEK J A GUNARATNE P H RICHARDS S WORLEY K C HALE S GARCIA A M GAY L J HULYK S W VILLALON D K MUZNY D M SODERGREN E J LU X GIBBS R A FAHEY J KETTEMAN M MADAN A RODRIGUES S SANCHEZ A WHITING M YOUNG A C SHEVCHENKO Y BOUFFARD G G BLAKESLEY R W TOUCHMAN J W GREEN E D DICKSON M C RODRIGUEZ A C GRIMWOOD J SCHMUTZ J MYERS R M BUTTERFIELD Y S KRZYWINSKI M I SKALSKA U SMAILUS D E SCHNERCH A SCHEIN J E JONES S J MARRA M A | 2002 | Proc Natl Acad Sci USA2002，99，16： | 1 |
| 19 | Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations显示文摘 | Dworkin RH Backonja M Rowbotham MC Allen RR Argoff CR Bennett GJ Bushnell MC Farrar JT Galer BS Haythornthwaite JA Hewitt DJ Loeser JD Max MB Saltarelli M Schmader KE Stein C Thompson D Turk DC Wallace MS Watkins LR Weinstein SM | 2003 | Arch Neurol2003，60，11： | 1 |
| 20 | Five-year follow-up of a prospective non-randomised study comparing duodenum-preserving pancreatic head resection with classic Whipple procedure in the treatment of chronic pancreatitis显示文摘 | Mobius C Max D Uhlmann D etal | 2007 | Langenbecks Arch Surg2007，392，3： | 1 |
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