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| 1 | De-regulation of the RBBP6 isoform 3/DWNN in human cancers显示文摘 | Mbita Z Meyer M Skepu A | | 0，，1： | 1 |
| 2 | Human immunodeficiency virus-1 (HIV-1)-mediated apoptosis: new therapeutic targets显示文摘 | Mbita Z Hull R Dlamini Z | 2014 | Viruses2014，6，8： | 1 |
| 3 | Genealogy,expression,and molecular mechanisms in apoptosis显示文摘 | Dlamini Z Mbita Z Zungu M | | 0，，01： | 1 |
| 4 | Genealogy, expression, and molecular mechanisms in apoptosis显示文摘 | Dlamini Z Mbita Z Zungu M | 2004 | Pharmacol Therapeut2004，，101： | 1 |
| 5 | Genealogy,expression and molecular mechanisms in apoptosis显示文摘 | Dlamini Z Mbita Z Zungu M | 2004 | Pharmacol Ther2004，101，1： | 1 |
| 6 | De-regulation of the RBBP6 isoform 3/DWNN in human cancers显示文摘 | Mbita Z Meyer M Skepu A | 2012 | Mol Cell Bin- ehem2012，362，12： | 1 |
| 7 | Genealogy, expression, and molecular mechanisms in apoptosis 显示文摘 | Dlamini Z Mbita Z Zunqu M | 2004 | Pharmacol Ther2004，10，1： | 1 |
| 8 | Origin and intraplate tectonic setting of mafic magmatic enclaves from the Ngaoundal area,Adamawa-Cameroon:Insights from petrography and geochemistry显示文摘In this contribution,detailed field descriptions together with petrographic and bulk-rock major,trace and rare earth elements(REE)data are used to constrain the origin and geodynamic setting of the mafic magmatic enclaves(MMEs)recently discovered within the Pan-African Ngaoundal pluton,Adamawa area,central Cameroon.The investigated MMEs are dark-colored with chilled margins,and display medium to coarse-grain igneous textures.The mineral assemblage is either dominated by K-feldspar and carbonate(group Ⅰ),or by amphibole and plagioclase(group Ⅱ),though the overall mineral phases made of amphibole,plagioclase,K-feldspar,and biotite are similar to that of their host syenite but in different proportions.The MMEs in Ngaoundal area are foid-gabbro in composition with SiO_(2) contents ranging between 41.52% and 43.74% and are contiguous with their host granitoids of intermediate composition(SiO_(2)=57.52% to 58.98%).The host granitoid rocks are metaluminous,and belong to the shoshonitic series.Petrographic and geochemical data have revealed that the Ngaoundal MMEs derived from rapid cooling of hot injected lithospheric mantle-derived magma within cooler host granitoids magma and were emplaced in the intraplate geodynamic setting. | Aliou Mamouda Sylvestre Ganno Guy Tchoupe Takam Bertin Arnold Mbita Motto Steven Hermann Donald Fossi Jean Paul Nzenti Joseph Mvondo Ondoa | 2022 | China Geology2022，5，4： | 0 |
| 9 | Drimia calcarata Bulb Extracts Deactivate the PI3K Signalling Pathway in Cervical HPV-18 Positive HeLa Cells显示文摘Background:The efficacy of Drimia calcarata against the human cervical cancer remains unexplored and less understood.Objective:The present study focused on investigating the cytotoxic effect of D.calcarata bulb extracts on cervical cancer cells.Methods:The growth inhibitory effects of D.calcarata extracts were determined using the MTT,Ki67 and PI3K Activation assays.Apoptosis induction was assessed using fluorescence microscopy,the Muse■Cell Analyser and gene expression analysis by RT-PCR.The cytotoxicity of the fractions was evaluated using MTT assay and the apoptosis induction using Muse■Cell Analyser.Results:Both methanol extract(ME)and water extract(WE)showed safety against noncancerous KMST-6 and HEK-293 cells.The extracts exhibited anticancer activity against HeLa,with no significant cytotoxic effect against the Ca-Ski cells.The WE increased the Ki67 positive Ca-Ski population,while both ME and WE arrested HeLa cells at G2/M phase,and Ca-Ski cells in G0/G1 phase.AO/EB staining,Annexin V and Caspase 3/7 Activation revealed that the extracts significantly induced apoptosis in HeLa cells.In HeLa cells,the ME downregulated TP53 variants,while WE upregulated both TP53 variants in HeLa cells.Both extracts decreased the STAT5A and STAT5B mRNA expression in HeLa cells;however,these extracts upregulated cancer-promoting STAT3 in Ca-Ski cells.Additionally,these extracts inactivated the PI3K signalling pathway in HeLa cells but not in Ca-Ski cells.The resistance of the Ca-Ski cells to the D.calcarata extracts may be due to the upregulation of STAT3 and activated PI3K signalling pathway.The cytotoxicity and apoptosis induction in HeLa cells by D.calcarata extracts may be attributed to downregulation of STAT5A survival mechanisms.Water fractions 1,2,3 and 6 and methanol fractions 1 and 2 reduced cell viability of HeLa cells.Water fractions 2,3 and 6 and methanol fractions 1 and 3 induced apoptosis,which was preceded by secondary necrosis.However,water fraction 1 and methanol fraction 2 led to most cells undergoing necrotic cell death.There are several compounds that can be credited with the anticancer activities of the ME and WE extracts since several fractions exhibited cytotoxicity against the HeLa cells.Conclusion:These findings suggest that the D.calcarata extracts have anticancer activities,and thus,could be useful for therapeutic purposes against human HPV-18 positive gynaecologic cancers. | Kagiso Laka Ladislaus Mdee Zukile Mbita | 2022 | Clinical Complementary Medicine and Pharmacology2022，2，4： | 0 |
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