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| 1 | Claudin-11 and occludin are major contributors to Sertoli cell tight junction function, in vitro显示文摘Sertoli 房间紧密的连接(TJ ) 是血睾丸障碍的关键部件,在它扣押开发在生精的小管以内经历精子发生的细菌房间的地方。神经质地调整的 claudin-11 是在不孕涉及障碍功能和它的鼠科的猛烈结果的批评 transmembrane 蛋白质。我们试图估计份量上到 TJ 功能的 claudin-11 的贡献的意义在 vitro,使用调停 siRNA 的基因 silencing。我们也进行了 occludin 的贡献的分析, TJ 的另一内在的 transmembrane 蛋白质。claudin-11 或 occludin 的 Silencing 在一个不成熟的老鼠 Sertoli 房间文化模型用 siRNA 被进行。Transepithelial 电的抵抗被用来在整个文化估计份量上 TJ 功能。在 siRNA 处理以后的二天,房间为对 mRNA 的 RT-PCR 评价为连接蛋白质或 lyzed 的 immunocytochemical 本地化被修理表示。claudin-11, occludin,或两个的 Silencing 在 55% 的 TJ 功能导致了重要减少(P <0.01 ) , 51%(P <0.01 ) ,并且 62%(P <0.01 ) 分别地。数据在到 Sertoli 房间 TJ 的指向的蛋白质的本地化是有在 mRNA 表示和显著减小的重要减少的伴随物。我们提供 claudin-11 显著地贡献的量的证据(P <0.01 ) 到 Sertoli 房间 TJ 在 vitro 工作。有趣地, occludin,神经质地在不孕被调整然而并非含有直到迟了的成人生活,也是一重要(P <0.01 ) 贡献者到障碍功能。我们的数据与一致在清楚地为这些表明一个角色的 vivo 研究,在维持正常 TJ 障碍的蛋白质组织并且工作。 | Mark J McCabe Caroline FH Foo Marcel E Dinger Peter M Smooker Peter G Stanton | 2016 | Asian Journal of Andrology2016，18，4： | 7 |
| 2 | International Consensus Statement on surveillance and management of dysplasia in inflammatory bowel disease显示文摘 | Loren Laine Tonya Kaltenbach Alan Barkun Kenneth R. McQuaid Venkataraman Subramanian Roy Soetikno James E. East Francis A. Farraye Brian Feagan John Ioannidis Ralf Kiesslich Michael Krier Takayuki Matsumoto Robert P. McCabe Klaus M?nkemüller Robert Odze M | 2014 | Gastrointestinal Endoscopy2014，，： | 3 |
| 3 | Calcium intake effects on two year changes in body composition in young women显示文摘 | LIN Y C LYLE R M MCCABE I D | 2000 | Journal of American College of Nutrition2000，19，： | 2 |
| 4 | Relationships between identity and self-representations during adolescence 显示文摘 | Makros J McCabe M P | 2001 | Journal of youth and adolescence2001，30，5： | 1 |
| 5 | Differences in topographic characteristics computed from 100-and 1000-m resolution digital elevation model data 显示文摘 | David M W Gregory J McCabe | 2000 | Hydrological Processes2000，14，： | 1 |
| 6 | Rapid enumeration of respiratory viruses 显示文摘 | Ferris M M McCabe M O Doan L G | 2002 | Analytical Chemistry2002，74，8： | 1 |
| 7 | Improved synthetic coolants using a modified polyalkylene glycol 显示文摘 | Levesque A McCabe M | 1984 | Lubr Eng1984，40，： | 1 |
| 8 | Quality-of-life assessment in cancer treatment protocols: issues in protocol development 显示文摘 | Gotay CC Korn EL McCabe M | 1992 | J Nail Cancer Inst1992，84，8： | 1 |
| 9 | The effect of examining actual products or product descriptions on consumer preference显示文摘 | McCabe D B and Nowlis S M | 2003 | Journal of Consumer Psychology2003，13，4： | 1 |
| 10 | Attenuation of CD95-induced apoptosis by inorganic mercury:caspase-3 is not a direct target of low levels of Hg2+显示文摘 | McCabe MJ Jr Eckles KG Langdon M | 2005 | Toxicol Lett2005，155，1： | 1 |
| 11 | Genome-Wide Promoter Analysis of the SOX 4Transcriptional Networkin Prostate Cancer Cells显示文摘 | Scharer CD McCabe CD Ali-Seyed M | 2009 | Cancer Res2009，69，2： | 1 |
| 12 | School cli- mate : Research, policy, practice, and teacher education 显示文摘 | Cohen J Mccabe E M Michelli N M | 2009 | Teachers College Record2009，111，1： | 1 |
| 13 | Cancer DNA methylation: molecular mechanisms and clinical implications显示文摘 | McCabe M T Brandes J C Vertino P M | 2009 | Clin Cancer Res2009，15，12： | 1 |
| 14 | Validation of DNA and RNA real-time assays for food analysis using the hilA gene of Salmonella enterica serovars 显示文摘 | McCabe E M Burgess C M Walsh D | 2011 | Food Microbiol2011，28，1： | 1 |
| 15 | Magnetite pathogenesis and digenetic palate premature across the northern Appalachian basin显示文摘 | Jackson M Mccabe C Ballard M | 1988 | Geology1988，16，： | 1 |
| 16 | The GANA Program : A Tailoring Approach to Adapting Parent Child Interaction Therapy for Mexican Americans显示文摘 | Kristen M McCabe May Yeh Ann F Garland | 2005 | Education and Treatment of Children2005，28，2： | 1 |
| 17 | Ca^2+- dependent mechanisms of cytotoxicity and programmed cell death显示文摘 | ORRENIUS S MCCABE M NICOTERA P | 1992 | Toxicol Lett1992，6465，： | 1 |
| 18 | Cancer DNA methylation: molecular mechanisms and clinical implications 显示文摘 | MCCABE M T BRANDES J C VERTINO P M | 2009 | Clin Cancer Res2009，15，12： | 1 |
| 19 | Postoperative spinal wound infection:a review of 2,391 consecutive index procedures显示文摘 | Weinstein M A McCabe J P Cammisa F P Jr | 2001 | J Spinal Disord2001，13，5： | 1 |
| 20 | Scale influence on the remote estimation of evapotranspiration using multiple satellite sensors显示文摘 | McCabe M F Wood E F | 2006 | Remote Sensing of Environment2006，105，4： | 1 |
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