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| 1 | Claudin-11 and occludin are major contributors to Sertoli cell tight junction function, in vitro显示文摘Sertoli 房间紧密的连接(TJ ) 是血睾丸障碍的关键部件,在它扣押开发在生精的小管以内经历精子发生的细菌房间的地方。神经质地调整的 claudin-11 是在不孕涉及障碍功能和它的鼠科的猛烈结果的批评 transmembrane 蛋白质。我们试图估计份量上到 TJ 功能的 claudin-11 的贡献的意义在 vitro,使用调停 siRNA 的基因 silencing。我们也进行了 occludin 的贡献的分析, TJ 的另一内在的 transmembrane 蛋白质。claudin-11 或 occludin 的 Silencing 在一个不成熟的老鼠 Sertoli 房间文化模型用 siRNA 被进行。Transepithelial 电的抵抗被用来在整个文化估计份量上 TJ 功能。在 siRNA 处理以后的二天,房间为对 mRNA 的 RT-PCR 评价为连接蛋白质或 lyzed 的 immunocytochemical 本地化被修理表示。claudin-11, occludin,或两个的 Silencing 在 55% 的 TJ 功能导致了重要减少(P <0.01 ) , 51%(P <0.01 ) ,并且 62%(P <0.01 ) 分别地。数据在到 Sertoli 房间 TJ 的指向的蛋白质的本地化是有在 mRNA 表示和显著减小的重要减少的伴随物。我们提供 claudin-11 显著地贡献的量的证据(P <0.01 ) 到 Sertoli 房间 TJ 在 vitro 工作。有趣地, occludin,神经质地在不孕被调整然而并非含有直到迟了的成人生活,也是一重要(P <0.01 ) 贡献者到障碍功能。我们的数据与一致在清楚地为这些表明一个角色的 vivo 研究,在维持正常 TJ 障碍的蛋白质组织并且工作。 | Mark J McCabe Caroline FH Foo Marcel E Dinger Peter M Smooker Peter G Stanton | 2016 | Asian Journal of Andrology2016，18，4： | 7 |
| 2 | Relationships between identity and self-representations during adolescence 显示文摘 | Makros J McCabe M P | 2001 | Journal of youth and adolescence2001，30，5： | 1 |
| 3 | Differences in topographic characteristics computed from 100-and 1000-m resolution digital elevation model data 显示文摘 | David M W Gregory J McCabe | 2000 | Hydrological Processes2000，14，： | 1 |
| 4 | School cli- mate : Research, policy, practice, and teacher education 显示文摘 | Cohen J Mccabe E M Michelli N M | 2009 | Teachers College Record2009，111，1： | 1 |
| 5 | Cancer DNA methylation: molecular mechanisms and clinical implications显示文摘 | McCabe M T Brandes J C Vertino P M | 2009 | Clin Cancer Res2009，15，12： | 1 |
| 6 | Cancer DNA methylation: molecular mechanisms and clinical implications 显示文摘 | MCCABE M T BRANDES J C VERTINO P M | 2009 | Clin Cancer Res2009，15，12： | 1 |
| 7 | Postoperative spinal wound infection:a review of 2,391 consecutive index procedures显示文摘 | Weinstein M A McCabe J P Cammisa F P Jr | 2001 | J Spinal Disord2001，13，5： | 1 |
| 8 | Protocol for a randomized controlled trial of a specialized health coaching intervention to prevent excessive gestational weight gain and postpartum weight retention in women: the HIPP study 显示文摘 | Skouteris H McCabe M Milgrom J | 2012 | BMC Public Health2012，12，： | 1 |
| 9 | Rearrangements of the MLL gene in therapy-related acute myeloid leukemia in patients previously treated with agents targetiug DNA-topoiso-merase I 显示文摘 | Super H J McCabe N R Thirman M J | 1993 | Blood1993，82，： | 1 |
| 10 | Athermal and thermally activeated plastic flow melting temperature solders at small stresses显示文摘 | McCabe R J Fine M E | 1998 | Scripta Materialia1998，39，2： | 1 |
| 11 | Polybrominated diphenyl ethers and polybrominated biphenyls in sediment and floodplain soils of the Saginaw River watershed, Michigan, USA 显示文摘 | Yun S H Addink R McCabe J M | 2008 | Archives of Environmental Contamination and Toxicology2008，55，1： | 1 |
| 12 | Effects of spatial aggregation on the multi-scale estimation of evapotranspira- tion显示文摘 | Ershadi A McCabe M F Evans J P | 2013 | Remote Sensing of Environment2013，131，： | 1 |
| 13 | Fatal cerebral reperfusion hemorrhage after carotid stenting显示文摘 | McCabe D J Brown M M Clifton A | 1999 | Stroke1999，30，11： | 1 |
| 14 | Protracted CRP eleva- tion after atrial fibrillation ablation 显示文摘 | Mccabe J M Smith L M Tseng Z H | 2008 | Pacing Clin Electrophysiol2008，31，9： | 1 |
| 15 | T-DNA transfer, integration, expression and inheritance in rice: effects of plant genotype and Agrobacterium super-virulence 显示文摘 | Azhakanandam K McCabe M S Power J B | 2000 | Journal of Plant Physiology2000，157，4： | 1 |
| 16 | Information goods and endogenous pricing strategies: the case of academic journals 显示文摘 | MCCABE M J | 2004 | Economics Bulletin2004，12，10： | 1 |
| 17 | The creep properties of precipitation-strengthened tin-based alloys 显示文摘 | MCCABE R J FINE M E | 2000 | J Miner2000，52，6： | 1 |
| 18 | Comparison of Single and Multiple Flow Direction Algorithms for Computing Topographic Parameters in TOPMODEL 显示文摘 | Wolock D M Mccabe G J | 1995 | Water Resource Research1995，，31： | 1 |
| 19 | Comparison of single and multiple flow direction algorithms for computing topographic parameters in TOPMODEL显示文摘 | McCabe Jr G J | 1995 | Water Resour Res1995，31，： | 1 |
| 20 | Cancer DNA methylation: molecular mechanisms and clinical implications显示文摘 | MCCABE M T BRANDES J C VERTINO P M | 2009 | Clin Cancer Res2009，15，12： | 1 |
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