|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Evaluation of the conceptual flow model for a deep vadose zone system using advanced tensiometers显示文摘 | McElroy D L Hubbell J M | 2004 | Vadose Zone Journal2004，3，1： | 1 |
| 2 | Nocturnal 02 onrichment of room air at high altitude increases daytime 02 Saturation without changing control of ventilation显示文摘 | Gerard A Powell F L | 2000 | High Alt Med Biol2000，1，3： | 1 |
| 3 | Feline aminopeptidase N is not a functional receptor for avian infectious bronchitis virus显示文摘 | Chu V C Mcelroy L J Aronson J M | | 0，，04： | 1 |
| 4 | Feline aminopeptidase N is not a functional receptor for avian infectious bronchitis virus显示文摘 | Chu V C Mcelroy L J Aronson J M | 2007 | Virology Journal2007，4，： | 1 |
| 5 | The production of polyclonal antibodies agalnst the mycotoxin derivative patulin hemiglutarate 显示文摘 | Mcelroy L J Weiss C M | 1993 | Can J Microbiol1993，39，9： | 1 |
| 6 | Occupational exposure to electromagnetic field and breast cancer risk in a large, population-based, case-control study in the United States 显示文摘 | McElroy J A Egan K M Titus-Ernstoff L | 2007 | Journal of Occupational and Environmental Medicine2007，49，3： | 1 |
| 7 | Exerciseinduced Reduction in Myocardial Infarct Size after Coronary Artery Occlusion in the Rat显示文摘 | MCELROY C L GISSEN S A FISHBEIN M C | 1978 | Circulation1978，57，： | 1 |
| 8 | Feline aminopeptidase N is not a functional receptor for avian infectious bronchitis virus 显示文摘 | CHU V C MCElroy L J ARONSON J M | 2007 | Virol J2007，4，： | 1 |
| 9 | Insulators with contaminated surfaces, part Ⅱ: modeling of discharge mecha- nisms显示文摘 | McElroy A J Lyon W L Phelps J D M | 1970 | IEEE Transactions on Power Apparatus and Sys- tems1970，89，8： | 1 |
| 10 | Correlates of treat- mentemergent mania associated with antidepressant treatment inbipolar depression显示文摘 | Frye M A HellemanG McElroy S L | 2009 | Am J Psychiatry2009，166，2： | 1 |
| 11 | The Role of Technolo-gy in Clinician-to-Clinician Communication显示文摘 | Mcelroy L M Ladner D P Holl J L | 2013 | BMJ QualSaf2013，，7： | 1 |
| 12 | Nocturnal O2 enrichment of room air at high altitude increases daytime O2 saturation without changing control of ventilation 显示文摘 | Mcelroy M K Gerard A Powell F L | 2000 | High altitude medicine and biology2000，1，3： | 1 |
| 13 | Nocturnal O2 enrichment room air at high altitude increases daytime O2 saturation without changing control of ventilation显示文摘 | Mcelroy M K Gerard A Powell F L | 2000 | High Altitude Medicine and Biology2000，1，3： | 1 |
| 14 | influence of lime- stone and phytase on broiler performance,gastrointestinal pH, and apparent ileal nutrient digestibility显示文摘 | Walk C L Bedford M R McElroy A P | 2012 | Poult Sci2012，91，6： | 1 |
| 15 | Correlates of treatment-emergent mania associated with antidepressant treatment in bipolar depression显示文摘 | Frye M A Helleman G McElroy S L | 2009 | Am J Psychiatry2009，166，2： | 1 |
| 16 | Olanzapine in the treatment-resistant bipolar disorder显示文摘 | Frye M Denicoff K | 1998 | J Affect Disord1998，49，2： | 1 |
| 17 | Feline aminopeptidase N is not a functional receptor for avian infectious bronchitis virus显示文摘 | CHU V C MCELROY L J ARONSON J M | 2007 | girol J2007，4，20： | 1 |
| 18 | The production of polyclonal antibodies against the mycotoxin derivative patulin hemiglutarate显示文摘 | McELROY L J WEISS C M | 1993 | Can J Microbiol1993，39，9： | 1 |
| 19 | Exercise -induced Reduction in Myocardial Infarct Size after Co ronary Artery Occlusion in the Rat 显示文摘 | MCELROY C L GISSEN S A F ISHBE IN M C | 1978 | Circulation1978，57，95： | 1 |
| 20 | A clinically relevant combination treatment with doxorubicin and cyclophosphamide does not induce hepatotoxicity in C57BL/6J mice显示文摘Background and aims:Chronic exposure to chemotherapeutics can lead to severe adverse events including hepatotoxicity.A combination chemotherapy regimen of doxorubicin(DOX)and cyclophos-phamide(CPS)is employed in treatment of several cancers such as leukemia,lymphoma,and breast cancer.It is not well understood whether a combination therapy with DOX and CPS can induce hepa-totoxicity.We therefore sought to determine whether co-administration of DOX and CPS at their clini-cally relevant doses and frequency results in hepatotoxicity.Methods:Male C57BL/6J mice received one intraperitoneal injection of saline or DOX-2 mg/kg and CPS-50 mg/kg once a week for 4 weeks.After the treatment period,liver histology and various serum bio-markers of hepatotoxicity were assessed.Results:Co-treatment with DOX and CPS did not alter the serum levels of alanine aminotransferase(ALT),alkaline phosphatase(ALP),bilirubin,albumin,globulin,or total protein.Similarly,co-administration of DOX and CPS did not result in a noticeable change in liver histology.However,it was notable that the concomitant treatment with DOX and CPS resulted in a significant increase in serum levels of aspartate aminotransferase(AST).Elevated serum AST levels were also associated with increased serum creatinine kinase(CK)levels,suggesting that the elevated serum AST levels are likely due to muscle injury following the co-administration of DOX and CPS.Conclusions:Taken together,our results,for the first time,suggest that co-administration of DOX and CPS,at their clinically relevant doses and frequency does not induce a significant hepatotoxicity in the mice. | Satyanarayana R Pondugula Julia M Salamat Kodye L Abbott Patrick C Flannery Mohammed Majrashi Mohammed Almaghrabi Manoj Govindarajulu Sindhu Ramesh Maninder Sandey Suneel K Onterue Chen-Che J Huang Yoshimi Iwaki Kristina Gill Natasha Narayanan Edwin McElroy Darshini Desai Rishi Nadar Timothy Moore Muralikrishnan Dhanasekaran | 2021 | Liver Research2021，5，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员