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| 1 | Curcumin reverses T cell-mediated adaptive immune dysfunctions in tumor-bearing hosts显示文摘Immune dysfunction is well documented during tumor progression and likely contributes to tumor immune evasion.CD81 cytotoxic T lymphocytes(CTLs)are involved in antigen-specific tumor destruction and CD41 T cells are essential for helping this CD81 T cell-dependent tumor eradication.Tumors often target and inhibit T-cell function to escape from immune surveillance.This dysfunction includes loss of effector and memory T cells,bias towards type 2 cytokines and expansion of T regulatory(Treg)cells.Curcumin has previously been shown to have antitumor activity and some research has addressed the immunoprotective potential of this plant-derived polyphenol in tumor-bearing hosts.Here we examined the role of curcumin in the prevention of tumor-induced dysfunction of T cell-based immune responses.We observed severe loss of both effector and memory T-cell populations,downregulation of type 1 and upregulation of type 2 immune responses and decreased proliferation of effector T cells in the presence of tumors.Curcumin,in turn,prevented this loss of T cells,expanded central memory T cell(TCM)/effector memory T cell(TEM)populations,reversed the type 2 immune bias and attenuated the tumor-induced inhibition of T-cell proliferation in tumor-bearing hosts.Further investigation revealed that tumor burden upregulated Treg cell populations and stimulated the production of the immunosuppressive cytokines transforming growth factor(TGF)-b and IL-10 in these cells.Curcumin,however,inhibited the suppressive activity of Treg cells by downregulating the production of TGF-b and IL-10 in these cells.More importantly,curcumin treatment enhanced the ability of effector T cells to kill cancer cells.Overall,our observations suggest that the unique properties of curcumin may be exploited for successful attenuation of tumor-induced suppression of cell-mediated immune responses. | Sankar Bhattacharyya Dewan Md Sakib Hossain Suchismita Mohanty Gouri Sankar Sen Sreya Chattopadhyay Shuvomoy Banerjee Juni Chakraborty Kaushik Das Diptendra Sarkar Tanya Das Gaurisankar Sa | 2010 | Cellular & Molecular Immunology2010，7，4： | 7 |
| 2 | Animal models of fulminant hepatic failure显示文摘 | John Terblanche ChM FCS(SA) FRCS(Eng) FRCPS(Glasg) FACS(Hon) Rosemary Hickman ChM MD | 1991 | Digestive Diseases and Sciences1991，，6： | 2 |
| 3 | Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia显示文摘 | Bernard SA Gray TW Buist MD | 2002 | N Engl J Med2002，346，8： | 1 |
| 4 | Treatment of comatose survivors of ont-of-hespital cardiac arrest with induced hypothennia显示文摘 | Bernard SA Gray TW Buist MD | 2002 | N Engl J Med2002，346，8： | 1 |
| 5 | Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia 显示文摘 | Bernard SA Gray TW Buist MD | 2002 | N EnglJMed2002，346，8： | 1 |
| 6 | Ectopic pregnancy显示文摘 | Pisarska MD Carson SA Buster JE | 1998 | Lancet1998，351，9109： | 1 |
| 7 | Accumu- lation of the common mitochondrial DNA deletion indu- ced by ionizing radiation显示文摘 | Prithivirajsingh S Story MD Bergh SA | 2004 | FEBS Lett2004，571，123： | 1 |
| 8 | Novel platelet membrane glycoprotein Ⅵ dimorphism is a risk factor for myocardial infarction显示文摘 | Croft SA Samani NJ Teare MD | 2001 | circulation2001，，13： | 1 |
| 9 | Preferred reti- nal locus development In patients with macular disease显示文摘 | Crossland MD Culham LE Kabanarou SA | 2005 | Oph- thalmology2005，112，9： | 1 |
| 10 | Decreases in bone blood flow and bone material properties in aging Fischer-344 rats显示文摘 | Bloomfield SA Hogan HA Delp MD | 2002 | Clin Orthop2002，396，3： | 1 |
| 11 | Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia显示文摘 | Gray TW Buist MD | 2002 | N Engl J Med2002，346，12： | 1 |
| 12 | Cim obsfet显示文摘 | Pisarska MD Carson SA | 1999 | Gynecol1999，42，1： | 1 |
| 13 | Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia 显示文摘 | Bernard SA Gray TW Buist MD | 2002 | N Engl J Med2002，346，8： | 1 |
| 14 | Penetrating kerato-plasty for macular comeal dystrophy 显示文摘 | Al-Swailem SA AI-Rajhi AA Wagoner MD | 2005 | Ophthalmology2005，112，2： | 1 |
| 15 | Angiogenic factorsin diagnosis, management, and research in preeelampsia 显示文摘 | Rana S Karumanchi SA Lindheimer MD | 2014 | Hypertension2014，63，2： | 1 |
| 16 | Marine ecoregions of the world:a bioregionalization of coastal and shelf areas显示文摘 | Spalding MD Fox HE Allen GR Davidson N Ferdafia ZA Finlayson M Halpern BS Jorge MA Lombana AL Lourie SA Martin KD Manus EC Molnar J Recchia CA Robertson J | | 0，，： | 1 |
| 17 | Cyclosporine augments hepatic regenerative response in rats显示文摘 | D. Kahn ChM FCS (SA) L. Makowka MD PhD H. Lai MD P. K. Eagon PhD V. Dindzans MD T. E. Starzl MD PhD Dr. D. H. Thiel MD | 1990 | Digestive Diseases and Sciences1990，，3： | 1 |
| 18 | Femoral diaph- ysealendoprosthetic reconstruction after segmental re- section of primary bone tumors 显示文摘 | Hanna SA Sewell MD Aston WJ | 2010 | J Bone Joint Surg (Br)2010，92，6： | 1 |
| 19 | Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia显示文摘 | Bernard SA Gray TW Buist MD | 2002 | N Engl J Med2002，346，8： | 1 |
| 20 | High resolution computed tomographic assessment of airway wall thickness in chronic asthma:reproducibility and relationship with lung function and severity显示文摘 | Litter SA Sproule MW Cowan MD | 2002 | Thorax2002，57，： | 1 |
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