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| 1 | Multimodality functional imaging using DW-MRI and 18F-FDG-PET/CT during radiation therapy for human papillomavirus negative head and neck squamous cell carcinoma: Meixoeiro Hospital of Vigo Experience显示文摘AIM To noninvasively investigate tumor cellularity measured using diffusion-weighted magnetic resonance imaging(DW-MRI) and glucose metabolism measured by 18 Flabeled fluorodeoxyglucose positron emission tomography/computed tomography(18F-FDG-PET/CT) during radiation therapy(RT) for human papillomavirus negative(HPV-) head and neck squamous cell carcinoma(HNSCC).METHODS In this prospective study, 6 HPV- HNSCC patients underwent a total of 34 multimodality imaging examinations(DW-MRI at 1.5 T Philips MRI scanner [(n = 24) pre-, during-(2-3 wk), and post-treatment(Tx), and 18F-FDG PET/CT pre- and post-Tx(n = 10)]. All patients received RT. Monoexponential modeling of the DW-MRI data yielded the imaging metric apparent diffusion coefficient(ADC) and the mean of standardized uptake value(SUV) was measured from 18F-FDG PET uptake. All patients had a clinical follow-up as the standard of care and survival status was documented at 1 year.RESULTS There was a strong negative correlation between the mean of pretreatment ADC(ρ =-0.67, P = 0.01) and the pretreatment 18F-FDG PET SUV. The percentage(%) change in delta(?) ADC for primary tumors and neck nodal metastases between pre- and Wk2-3 Tx were as follows: 75.4% and 61.6%, respectively, for the patient with no evidence of disease, 27.5% and 32.7%, respectively, for those patients who were alive with disease, and 26.9% and 7.31%, respectively, for those who were dead with disease.CONCLUSION These results are preliminary in nature and are indicative, and not definitive, trends rendered by the imaging metrics due to the small sample size of HPV- HNSCC patients in a Meixoeiro Hospital of Vigo Experience. | David Aramburu Núnez Antonio Lopez Medina Moisés Mera Iglesias Francisco Salvador Gomez Abhay Dave Vaios Hatzoglou Ramesh Paudyal Alfonso Calzado Joseph O Deasy Amita Shukla-Dave Victor M Munoz | 2017 | World Journal of Radiology2017，9，1： | 2 |
| 2 | Poly(ADP-ribose) polymerase suppression protects rheumatoid synovial fibroblasts from Fas-induced apoptosis显示文摘 | García S Mera A Conde C | 2009 | Rheumatology (Oxford)2009，48，5： | 1 |
| 3 | Multiplex cytokine profiling in patients with sepsis显示文摘 | Mera S Tatulescu D Cismaru C | 2011 | APMIS2011，119，2： | 1 |
| 4 | Clinicopathologic study on prognostic marker in IgA nephropathy显示文摘 | Mera J Uchida S Nagase M | 2000 | Nephron2000，84，2： | 1 |
| 5 | Anticoagulant treatment of deep vein thrombosis and pulmonary embolism显示文摘 | Tran H MeRae S Ginsberg J | 2006 | Clin Gerialr Med2006，22，1： | 1 |
| 6 | Multiplex cytokine profi- ling in patients with sepsis 显示文摘 | Mera S Tatulescu D Cismaru C | 2011 | APMIS2011，119，2： | 1 |
| 7 | Can repetitive magnetic stimulation improve cognition in schizophrenia?Pilot data from a randomized controlled trial显示文摘 | Mera S Faranak F Tarek K | 2013 | Biological Psychiatry2013，73，： | 1 |
| 8 | Influence of number of pregnancies and total breast-feeding time mineral density 显示文摘 | Carranza-Lira S Mera JP | 2002 | Int J Fertil Womens Meal2002，47，4： | 1 |
| 9 | A comparison of boundary element method formulations for steady state anisotropic heat conduction problems显示文摘 | MERA N S ELLIOTT L INGHAM D B LESNIC D | 2001 | Engineering analysis with boundary elements2001，25，： | 1 |
| 10 | The method of fundamental solutions for the backward heat conduction problem显示文摘 | MERA N S | 2005 | Inv Prob Sci Engrg2005，13，1： | 1 |
| 11 | Selective site pacing from the fightventricular mid-septum 显示文摘 | Yusu S Mera H Hoshida K | 2012 | Int Heart J2012，53，2： | 1 |
| 12 | A comparison of boundary element method formulations for steady state anisotropic heat conduction problems显示文摘 | Mera N S Elliott L Ingham D B | 2001 | Engineering Analysis with Boundary Elements2001，25，11： | 1 |
| 13 | Detection of subsurface cavities in IR-CAT by a real coded genetic algorithm显示文摘 | Mera N S Elliott L Ingham D B | 2002 | Applied Soft Computing2002，2，： | 1 |
| 14 | Clinicopathologic study on prognostic markers in IgA nephropathy显示文摘 | Mera J Uchida S Nagase M | 2000 | Nephron2000，84，1： | 1 |
| 15 | Repeated social defeat stress induces chronic hyperthermia in rats显示文摘 | Hayashida S Oka T Mera T | 2010 | Physiol Behav2010，101，1： | 1 |
| 16 | Potential individual versus simultaneous climate change effects on soybean (C-3) and maize (C-4) crops:an agrotechnology model based study显示文摘 | Mera R J Niyogi D Buol G S | 2006 | Global and Planetary Change2006，54，12： | 1 |
| 17 | Clinicopathologic study on prongnostic markers in IgA nephropathy显示文摘 | Mera J Uchida S Nagase M | 2000 | Nephron2000，84，2： | 1 |
| 18 | An iterative boundary element method for solving the one dimensional backward heat conduction problem显示文摘 | MERA N S ELLIOTT L INGHAM D B | 2001 | International Journal of Heat and Mass Transfer2001，44，10： | 1 |
| 19 | Cartilage repair with autologous bone marrow mesenchymal stem cell transplantation:review of preclinical and clinical studies显示文摘 | Yamasaki S Mera H Itokazu M | 2014 | Cartilage2014，5，4： | 1 |
| 20 | Poly ( ADP-ribose ) polymerase suppression protects rheumatoid synovial fibroblasts from Fas-indueed apoptosis显示文摘 | Garcia S Mera A Gomez R J | 2009 | Rheumatology ( Oxford )2009，48，5： | 1 |
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