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| 1 | Virological course of hepatitis A virus as determined by real time RT-PCR: Correlation with biochemical, immunological and genotypic profiles显示文摘瞄准:承担肝炎 A 的分析,并且相关病毒的负担,丙氨酸 aminotransferase (中高音) ,和有病毒血的持续时间的病毒的遗传型有控制调停房间的免疫的 CD4 (+)/ CD8 (+) 淋巴细胞人口的这些参数。方法:房间计数用用荧光在乙二胺四乙酸小瓶收集的新鲜全血被执行激活的房间 sorter。肝炎 A 病毒(HAV ) RNA 从血浆液被提取,抄录进 cDNA 并且由实时聚合酶链反应确定了并且是 genotyped 的颠倒。结果:在 11 个病人之中, 10 能完全被分析。这些, 3 有严重尖锐肝炎(s -- 啊) 并且剩余物有自我限制尖锐肝炎 A (啊哈) ,在第 4 d 上与有暴发性的疾病(脑病等级 IV ) 的一个病人一起死。中高音水平在啊哈两个都是显著地更高的(1070.9 +/- 894.3;P = 0.0014 ) 并且 s -- 啊(1713.9 +/- 886.3;P = 0.001 ) 与正常控制相比(23.6 +/- 7.2 ) 。在 s 的前凝血酶时间 -- 啊病人(21.0 +/- 2.0;P = 0.02 ) 比在啊哈显著地高(14.3 +/- 1.1;P = 0.44 ) 。在啊哈病人的 CD4 (+)/CD8 (+) 比率(1.17 +/- 0.11;P = 0.22 ) 并且 s -- 啊(0.83 +/- 0.12;P = 0.0002 ) 比在正常健康控制(1.52 ) 看低。有的自我限制盒子达到顶点在分析的开始的病毒的负担当时在 s -- 啊病人这发生在第 15 或第 30 d。在敏锐、严格的组,一耐心的各个属于遗传型 IA,与仍然是 8 个盒子属于遗传型 IIIA。唯一的暴发性的肝的失败大小写属于遗传型 IA。在自我限制感染的全部功课期间收集的 HAV 病毒的负担和中高音价值直接为 s 被相关,但是这不是事实 -- 啊病人。结论:基于小规模的研究, s 的固执地更高的病毒的负担 -- 啊可能由于减少的细胞免疫和溶血。病毒血的持续时间依赖于主人,当病毒的遗传型没在 AVH 和 s 的临床的结果有明显的角色 -- 啊盒子。 | Zahid Hussain Bhudev C Das Syed A Husain Sunil K Polipalli Tanzeel Ahmed Nargis Begum Subhash Medhi Alice Verghese Mohammad Raish Apiradee Theamboonlers Yong Poovorawan Premashis Kar | 2006 | World Journal of Gastroenterology2006，12，29： | 10 |
| 2 | Current status of pharmacological treatment of colorectal cancer显示文摘AIM: To review the clinical trials for the development in drugs for chemotherapeutic treatment of colorectal cancer(CRC).METHODS: A systematic review identified random-ized controlled trials(RCTs) assessing drugs for the treatment of CRC or adenomatous polyps from www.clinicaltrials.gov. Various online medical databases were searched for relevant publications.RESULTS: Combination treatment regimens of stan-dard drugs with newer agents have been shown to improve overall survival, disease-free survival, time to progression and quality of life compared to that with standard drugs alone in patients with advanced colorectal cancer. The FOLFOXIRI regimen has been associated with a significantly higher response rate, progression-free survival and overall survival compared to the FOLFIRI regimen. CONCLUSION: Oxaliplatin plus intravenous bolus fluo-rouracil and leucovorin has been shown to be superiorfor disease-free survival when compared to intravenous bolus fluorouracil and leucovorin. In addition, oxaliplatin regimens were more likely to result in successful surgi-cal resections. First line treatment with cetuximab plus fluorouracil, leucovorin and irinotecan has been found to reduce the risk of metastatic progression in patients with epidermal growth factor receptor-positive colorec-tal cancer with unresectable metastases. The addition of bevacizumab has been shown to significantly in-crease overall and progression-free survival when given in combination with standard therapy. | Reyhan Akhtar Shammy Chandel Pooja Sarotra Bikash Medhi | 2014 | World Journal of Gastrointestinal Oncology2014，6，6： | 3 |
| 3 | A Comprehensive Review of Animal Models for Coronaviruses: SARSCoV-2, SARS-CoV, and MERS-CoV显示文摘The recent outbreak of coronavirus disease(COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) has already affected a large population of the world. SARS-CoV-2 belongs to the same family of severe acute respiratory syndrome coronavirus(SARS-CoV) and Middle East respiratory syndrome coronavirus(MERSCoV). COVID-19 has a complex pathology involving severe acute respiratory infection, hyper-immune response, and coagulopathy. At present, there is no therapeutic drug or vaccine approved for the disease. There is an urgent need for an ideal animal model that can reflect clinical symptoms and underlying etiopathogenesis similar to COVID-19 patients which can be further used for evaluation of underlying mechanisms, potential vaccines, and therapeutic strategies. The current review provides a paramount insight into the available animal models of SARS-CoV-2, SARS-CoV, and MERS-CoV for the management of the diseases. | Ashutosh Singh Rahul Soloman Singh Phulen Sarma Gitika Batra Rupa Joshi Hardeep Kaur Amit Raj Sharma Ajay Prakash Bikash Medhi | 2020 | Virologica Sinica2020，35，3： | 3 |
| 4 | 优化遮盖力并降低钛白粉用量的先进遮盖聚合物与新型分散剂技术显示文摘钛白粉短缺以及由此而引起的价格上涨再次激励涂料化学家为增加涂料遮盖力而寻找这一关键原材料的替代品。针对这一目标,阿科玛最近推出了两种新技术──CelocorTM遮盖聚合物和能提高钛白粉遮盖效率的新型分散剂。本文介绍了这两种新技术产品的性能,并通过其在4种乳胶漆中的应用实例说明如何有效利用这两种技术的组合来显著降低涂料配方中所需钛白粉的用量。 | 伍文君 熊喜竹 Christine Fortener Medhi Bouzid Mike Kaufman 刘丽莉 | 2013 | 电镀与涂饰2013，32，9： | 3 |
| 5 | Viral Genotypes and Associated Risk Factors of Hepatocellular Carcinoma in India显示文摘Objective This study aims to investigate the etiological relationship among hepatitis B virus(HBV),hepatitis C virus(HCV),and alcohol as risk factors in a cohort of hepatocellular carcinoma(HCC) patients from India.The clinical and biochemical profiles and tumor characteristics in the HCC cases were also evaluated. Methods A total of 357 consecutive cases of HCC fulfilling the diagnostic criteria from the Barcelona-2000 EASL conference were included in the study.The blood samples were evaluated for serological evidence of HBV and HCV infection,viral load,and genotypes using serological tests,reverse transcription-polymerase chain reaction,and restriction fragment length polymorphism. Results The male/female ratio for the HCC cases was 5.87:1.Majority of the HCC patients(33.9% ) were 50 to 59 years of age,with a mean age of 4±13.23 years.More than half the cases(60.8% ) had underlying cirrhosis at presentation.Among the HCC patients,68.9% were HBV related,21.3% were HCV related,18.8% were alcoholic,and 18.2% were of cryptogenic origin.The presence of any marker positive for HBV increased the risk for developing HCC by almost 27 times[OR:27.33;(12.87-60.0)].An increased risk of 10.6 times was observed for HCC development for cases positive for any HCV marker[OR:10.55;(3.13-42.73)].Heavy alcohol consumption along with HCV RNA positivity in cirrhotic patients was found to be a risk for developing HCC by 3 folds[OR:3.17;(0.37-70.71)]. Conclusions Patients of chronic HBV infection followed by chronic HCV infection were at higher risk of developing HCC in India. Chronic alcohol consumption was found to be a risk factor in cirrhotic cases only when it was associated with HCV RNA positivity. Most of the patients had a large tumor size(>5 cm) with multiple liver nodules,indicating an advanced stage of the disease thus making curative therapies difficult. | Manash Pratim Sarma Mohammad Asim Subhash Medhi Thayumanavan Bharathi Richa Diwan Premashis Kar | 2012 | Clinical oncology and cancer resexreh2012，9，3： | 2 |
| 6 | Phytochemistry and larvicidal activity of Eucalyptus camaldulensis against malaria vector,Anopheles stephensi显示文摘Objective:To determine phytochemistry and larvicidal activity of Eucalyptus eamaldulensis against Anopheles stephensi.Methods:The chemical compositions of the leaf essential oils were analyzed using gas chromatography/mass spectrometry(GC/MS).The larvicidal activity of essential oils and extract of leaf were tested against 4th instar larvae of laboratory-reared Anopheles stephensi.Results:GC/MS analyses identified the presence of 28 compounds corresponding to 99.60%of the total oil.The main constituents in the leaf essential oil were 1,8-cineole(69.46%),γ-Terpinene(15.10%),α-Pinene(5.47%) and Globulol(2%).The leaf extract and volatile oil exerted significant larvicidal activity with LC50 values of 89.85 and 397.75 ppm,respectively.Clear dose-response relationships were established with the highest dose of 320 ppm essential oil extract resulted almost 100%mortality in the population.Conclusions:The larvicidal properties suggest that the essential oil of plant is a potential source of valuable larvicidal compounds against malaria vector and can be used as an alternative to synthetic insecticides. | Sedaghat Mohamad Medhi Sanei Dehkordi Ali Reza Khnavi Mahnaz Abai Mohammad Reza Hadjiakhoondi Abbas Mohtarami Fatemeh Vatandoost Hassan | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，11： | 2 |
| 7 | Cure and reinfection patterns of geohelminthic infections after treatment in communi- ties inhabiting the tropical rainforest of Assam, India 显示文摘 | Narain K Medhi GK Rajguru SK | 2004 | South- east Asian J Trop Med Public Health2004，35，3： | 1 |
| 8 | Evaluation of granular activated carbon technology for the removal of methyl tertiary butyl ether (MTBE) from drinking water 显示文摘 | Tom C S Medhi W Suffet M | 2003 | Water Research2003，37，2： | 1 |
| 9 | Efficacy and safety of an ad- vanced formula silicone gel for prevention of post-operative scars显示文摘 | Medhi B Sewal RK Kaman L | 2013 | Dermatol Ther (Heidelb)2013，3，2： | 1 |
| 10 | The development of the Greater Mekong Sub-region (GMS): real promise or false hope? 显示文摘 | Medhi Krongkaew | 2004 | Journal of Asian Economics2004，，15： | 1 |
| 11 | Diagnostic utility of hepatitis C virus core antigen in hemodialysis patients显示文摘 | Medhi S Potukuchi SK Polipalli SK | 2008 | Clin Bioehem2008，41，78： | 1 |
| 12 | Granulocyte colony stimulating factor(GCSF)improves memory andneurobehavior in an amyloid-βinduced experimental model of Alzheimer's disease显示文摘 | Prakash A Medhi B Chopra K | | 0，，： | 1 |
| 13 | The impact of self - retaining retractors on the paraspinal muscles during posterior spinal surgery 显示文摘 | Taylor H McGregor AH Medhi - Zadeh S | 2002 | Spine2002，27，24： | 1 |
| 14 | Pharmacokinetic and toxicological profile of artemisinin compounds:an update显示文摘 | Medhi B Patyar S Rao R S | 2009 | Pharmacology2009，84，6： | 1 |
| 15 | A single server poisson input queue with a second optional channel显示文摘 | Medhi J | 2002 | Queueing Systems2002，42，： | 1 |
| 16 | Role of polymorphic Nacetyl transferase2 and cytochrome P4502E1 gene in antituberculosis treatment-induced hepatitis显示文摘 | Bose PD Sarma MP Medhi S | | 0，，02： | 1 |
| 17 | Diagnostic utility of hepatitis C virus core antigen in hemodialysis patients显示文摘 | Medhi S Potukuchi SK Polipalli SK | 2008 | Clin Biochem2008，41，78： | 1 |
| 18 | Visual performance: comparison of foldable intraocular lenses 显示文摘 | Bhattacharjee H Bhattacharjee K Medhi J | 2006 | J Cataract Refract Surg2006，32，3： | 1 |
| 19 | Intestinal inflammation and seizure susceptibility: understanding the role of tumour necrosis factor-alpha in a rat model显示文摘 | Medhi B Prakash A Avti PK | 2009 | Pharm Pharmacol2009，61，10： | 1 |
| 20 | Congenital elevation of the scapula显示文摘 | Dendane AM Amrani A El Medhi T | 2004 | Tunis Med2004，82，： | 1 |
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