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| 1 | Diagnosis of alcoholic liver disease显示文摘Alcohol is a hepatotoxin that is commonly consumed worldwide and is associated with a spectrum of liver injury including simple steatosis or fatty liver, alcoholic hepatitis, fibrosis, and cirrhosis. Alcoholic liver disease(ALD) is a general term used to refer to this spectrum of alcohol-related liver injuries. Excessive or harmful alcohol use is ranked as one of the top five risk factors for death and disability globally and results in 2.5 million deaths and 69.4 million annual disability adjusted life years. All patients who present with clinical features of hepatitis or chronic liver disease or who have elevated serum elevated transaminase levels should be screened for an alcohol use disorder. The diagnosis of ALD can generally be made based on history, clinical and laboratory findings. However, the diagnosis of ALD can be clinically challenging as there is no single diagnostic test that confirms the diagnosis and patients may not be forthcoming about their degree of alcohol consumption. In addition, clinical findings may be absent or minimal in early ALD characterized by hepatic steatosis. Typical laboratory findings in ALD include transaminase levels with aspartate aminotransferase greater than alanine aminotransferase as well as increased mean cor-puscular volume, gamma-glutamyltranspeptidase, and IgA to IgG ratio. In unclear cases, the diagnosis can be supported by imaging and liver biopsy. The histological features of ALD can ultimately define the diagnosis according to the typical presence and distribution of hepatic steatosis, inflammation, and Mallory-Denk bodies. Because of the potential reversible nature of ALD with sobriety, regular screening of the general population and early diagnosis are essential. | Cara Torruellas Samuel W French Valentina Medici | 2014 | World Journal of Gastroenterology2014，20，33： | 26 |
| 2 | Wilson disease:Histopathological correlations with treatment on follow-up liver biopsies显示文摘AIM:To investigate the progression of hepatic histopathology in serial liver biopsies from Wilson disease(WD)patients.METHODS:We report a group of 12 WD patients treated with zinc and/or penicillamine who underwent multiple follow-up liver biopsies.Demographic,clinical and laboratory data were gathered and all patients underwent an initial biopsy and at least one repeat biopsy.RESULTS:Time to repeat biopsy ranged from 2 to 12 years.Six patients(non-progressors)showed stable hepatic histology or improvement.In one case,we observed improvement of fibrosis from stage 2 to 0.Six patients(progressors)had worsening of fibrosis.There was no significant correlation between the histological findings and serum aminotransferases or copper me-tabolism parameters.The hepatic copper concentration reached normal levels in only two patients:one from the non-progressors and one from the progressors group.The estimated rate of progression of hepatic fibrosis in the entire group was 0 units per year in the time frame between the first and the second liver biopsy(4 years),and 0.25 between the second and the third(3 years).In the progressors group,the rate of progression of liver fibrosis was estimated at 0.11 fibrosis units per year between the first and second biopsy and,0.6 fibrosis units between the second and third biopsy.CONCLUSION:The inability of clinical tools to detect fibrosis progression in WD suggests that a liver biopsy with hepatic copper quantification every 3 years should be considered. | Sandy Cope-Yokoyama Milton J Finegold Giacomo Carlo Sturniolo Kyoungmi Kim Claudia Mescoli Massimo Rugge Valentina Medici | 2010 | World Journal of Gastroenterology2010，16，12： | 10 |
| 3 | Therapeutic effect of Streptococcus thermophilus CRL 1190-fermented milk on chronic gastritis显示文摘AIM: To investigate the potential therapeutic effect of exopolysaccharide (EPS)-producing Streptococcus thermophilus (S. thermophilus) CRL 1190 fermented milk on chronic gastritis in Balb/c mice. METHODS: Balb/c mice were fed with the fermented milk for 7 d after inducing gastritis with acetyl-salicylic acid (ASA, 400 mg/kg body weight per day for 10 d). Omeprazole was included in this study as a positive therapeutic control. The gastric in? ammatory activity was evaluated from gastric histology and in? ammation score, number of interleukin-10 (IL-10), interferon-γ (INFγ) and tumor necrosis factor-α (TNF-α) cytokine-producing cells in the gastric mucosa, and thickness of the mucus layer. RESULTS: Animals receiving treatment with the EPS-producing S. thermophilus CRL 1190 fermented milk showed a conserved gastric mucosa structure similar to that of healthy animals. In? ammation scores of the fermented milk-treated mice were lower than those of mice in the gastritis group (0.2 ± 0.03 vs 2.0 ± 0.6, P < 0.05). A marked decrease in INFγ+ (15 ± 1.0 vs 28 ± 1.2, P < 0.05) and TNF-α+ (16 ± 3.0 vs 33 ± 3.0, P < 0.05) cells and an increase in IL-10+ (28 ± 1.5 vs 14 ± 1.3, P < 0.05) cells compared to the gastritis group, was observed. Also, an increase in the thickness of the mucus gel layer (2.2 ± 0.6 vs 1.0 ± 0.3; 5.1 ± 0.8 vs 1.5 ± 0.4 in the corpus and antrum mucosa, respectively, P < 0.05) compared with the gastritis group was noted. A milk suspension of the purif ied EPS from S. thermophilus CRL1190 was also effective as therapy for gastritis. | Cecilia Rodríguez Marta Medici Fernanda Mozzi Graciela Font de Valdez | 2010 | World Journal of Gastroenterology2010，16，13： | 5 |
| 4 | Liver transplantation for Wilson disease显示文摘The aim of this paper is to review the current status of liver transplantation (LT) for Wilson disease (WD), focusing on indications and controversies, especially in patients with neuropsychiatric disease, and on identification of acute liver failure (ALF) cases related to WD. LT remains the treatment of choice for patients with ALF, as initial presentation of WD or when anti-copper agents are stopped, and for patients with chronic liver disease progressed to cirrhosis, unresponsive to chelating medications or not timely treated with copper chelating agents. The indication for LT in WD remains highly debated in patients with progressive neurological deterioration and failure to improve with appropriate medical treatment. In case of Wilsonian ALF, early identification is key as mortality is 100% without emergency LT. As many of the copper metabolism parameters are believed to be less reliable in ALF, simple biochemical tests have been proposed for diagnosis of acute WD with good sensitivity and specificity. LT corrects copper metabolism and complications resulting from WD with excellent 1 and 5 year survival. Living related liver transplantation represents an alternative to deceased donor LT with excellent long-term survival, without disease recurrence. Future options mayinclude hepatocyte transplantation and gene therapy. Although both of these have shown promising results in animal models of WD, prospective human studies are much needed to demonstrate their long-term beneficial effects and their potential to replace the need for medical therapy and LT in patients with WD. | Andreea M Catana Valentina Medici | 2012 | World Journal of Hepatology2012，4，1： | 4 |
| 5 | Iron Mobilization and Mineralogical Alterations Induced by Iron-Deficient Cucumber Plants (Cucumis sativus L.) in a Calcareous Soil显示文摘Dicotyledons cope with ion(Fe) shortage by releasing low-molecular-weight organic compounds into the rhizosphere to mobilize Fe through reduction and complexation mechanisms. The effects induced by these root exudates on soil mineralogy and the connections between Fe mobilization and mineral weathering processes have not been completely clarified. In a batch experiment, we tested two different kinds of organic compounds commonly exuded by Fe-deficient plants, i.e., three organic acids(citrate, malate, and oxalate)and three flavonoids(rutin, quercetin, and genistein), alone or in combination, for their ability to mobilize Fe from a calcareous soil and modify its mineralogy. The effect of root exudates on soil mineralogy was assessed in vivo by cultivating Fe-deficient and Fe-sufficient cucumber plants(Cucumis sativus L.) in a RHIZOtest device. Mineralogical analyses were performed by X-ray powder diffraction. The batch experiment showed that citrate and, particularly, rutin(alone or combined with organic acids or genistein)promoted Fe mobilization from the soil. The combinations of rutin and organic acids modified the soil mineralogy by dissolving the amorphous fractions and promoting the formation of illite. These mineralogical alterations were significantly correlated with the amount of Fe mobilized from the soil. The RHIZOtest experiment revealed a drastic dissolution of amorphous components in the rhizosphere soil of Fe-deficient plants, possibly caused by the intense release of phenolics, amino acids, and organic acids, but without any formation of illite. Both batch and RHIZOtest experiments proved that exudates released by cucumber under Fe deficiency concurred to the rapid modification(on a day-scale) of the mineralogy of a calcareous soil. | Concetta Eliana GATTULLO Youry PII Ignazio ALLEGRETTA Luca MEDICI Stefano CESCO Tanja MIMMO Roberto TERZANO | 2018 | Pedosphere2018，28，1： | 3 |
| 6 | Wilson disease:At the crossroads between genetics and epigeneticsdA review of the evidence显示文摘Environmental factors,including diet,exercise,stress,and toxins,profoundly impact disease phenotypes.This review examines how Wilson disease(WD),an autosomal recessive genetic disorder,is influenced by genetic and environmental inputs.WD is caused by mutations in the copper-transporter gene ATP7B,leading to the accumulation of copper in the liver and brain,resulting in hepatic,neurological,and psychiatric symptoms.These symptoms range in severity and can first appear anytime between early childhood and old age.Over 300 disease-causing mutations in ATP7B have been identified,but attempts to link genotype to the phenotypic presentation have yielded little insight,prompting investigators to identify alternative mechanisms,such as epigenetics,to explain the highly varied clinical presentation.Further,WD is accompanied by structural and functional abnormalities in mitochondria,potentially altering the production of metabolites that are required for epigenetic regulation of gene expression.Notably,environmental exposure affects the regulation of gene expression and mitochondrial function.We present the“multi-hit”hypothesis of WD progression,which posits that the initial hit is an environmental factor that affects fetal gene expression and epigenetic mechanisms and subsequent“hits”are environmental exposures that occur in the offspring after birth.These environmental hits and subsequent changes in epigenetic regulation may impact copper accumulation and ultimately WD phenotype.Lifestyle changes,including diet,increased physical activity,stress reduction,and toxin avoidance,might influence the presentation and course of WD,and therefore may serve as potential adjunctive or replacement therapies. | Dorothy A.Kieffer Valentina Medici | 2017 | Liver Research2017，1，2： | 3 |
| 7 | Cytoskeleton involvement during human cytomegalovirus replicative cycle in humanembryo fibroblasts显示文摘 | Arcangeletti M C Pinardi F Medici M C | 2000 | New Microbiol2000，23，3： | 2 |
| 8 | The role of endothelial mesenchyrnal transition in hetemtopic ossificatior显示文摘 | Medici D Olsen BP | 2012 | J Bone Miner Res2012，27，8： | 1 |
| 9 | Biotransforma- tions on steroid nucleus of bile acids 显示文摘 | BORTOLINI O MEDICI A POLI S | 1997 | Steroids1997，62，89： | 1 |
| 10 | Diagnosis and management of Wilson's disease:results of a single center experience显示文摘 | Medici V Trevisan CP D'Inca R | 2006 | J Clin Gastroenterol2006，40，10： | 1 |
| 11 | Particulate sampling in the IMS radionuclide network of the comprehensive nuclear-test-ban treaty显示文摘 | Medici F | 2001 | Kemtechnik2001，66，3： | 1 |
| 12 | Cooperation between snail and LEF-1 transcription factors is essential for TGF-β1-induced epithelial-mesenchymal transition显示文摘 | Medici D Hay E D Goodenough D A | 2006 | Mol Biol Cell2006，17，4： | 1 |
| 13 | Discoidin domain receptor 2 is a critical regulator of epithelial-mesenchymal transition 显示文摘 | Walsh LA Nawshad A Medici D | 2011 | Matrix Biol2011，30，4： | 1 |
| 14 | Wilson disease:a practical approach to diagnosis, treatment and follow-up 显示文摘 | Medici V Rossaro L Sturniolo GC | 2007 | Dig Liver Dis2007，39，7： | 1 |
| 15 | Relationship between interaction sites in the gut, hydrophobicity, mucosal immunomodulating capacities and cell wall protein profiles in indigenous and exogenous bacteria 显示文摘 | Vinderola C G Medici M Perdigon G | 2004 | J Appl Microbiol2004，96，2： | 1 |
| 16 | Relationship between interaction sites in the gut,hydropbebicity, mucosal immunomodulafing capacities and cell wall protein profiles in indigenous and exogenous bacteria显示文摘 | VINDEROLA C G MEDICI M PERDIGON G | 2004 | J Appl Microbiol2004，96，2： | 1 |
| 17 | Control of human trophoblast function显示文摘 | Lunghi L Ferretti ME Medici S | 2007 | Reprod Biol Endocrinol2007，5，： | 1 |
| 18 | Conversion of vascular endothelial cells into multipotent stem-like cells显示文摘 | Damian Medici Eileen M Shore Vitali Y Lounev | | 0，，12： | 1 |
| 19 | Clinical and molecular obser- vations of two fatal cases of rotavirus - associated enteritis in children in Italy 显示文摘 | Medici MC Abelli LA Martinelli M | 2011 | Journal of clinical microbiology2011，49，7： | 1 |
| 20 | Identification of a DNA binding protein cooperating with estrogen receptor as RIZ(retinoblastoma interacting zinc finger protein)显示文摘 | Medici N Abbondanza C Nigro V | 1999 | Biochem Biophys Res Commun1999，264，3： | 1 |
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