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| 1 | Use of shear wave elastography for the diagnosis and follow-up of biliary atresia: A meta-analysis显示文摘BACKGROUND Timely differentiation of biliary atresia(BA)from other infantile cholestatic diseases can impact patient outcomes.Additionally,non-invasive staging of fibrosis after Kasai hepatoportoenterostomy has not been widely standardized.Shear wave elastography is an ultrasound modality that detects changes in tissue stiffness.The authors propose that the utility of elastography in BA can be elucidated through meta-analysis of existing studies.AIM To assess the utility of elastography in:(1)BA diagnosis,and(2)post-Kasai fibrosis surveillance.METHODS A literature search identified articles that evaluated elastography for BA diagnosis and for post-Kasai follow-up.Twenty studies met criteria for meta-analysis:Eleven for diagnosis and nine for follow-up post-Kasai.Estimated diagnostic odds ratio(DOR),sensitivity,and specificity of elastography were calculated through a random-effects model using Meta-DiSc software.RESULTS Mean liver stiffness in BA infants at diagnosis was significantly higher than in non-BA,with overall DOR 24.61,sensitivity 83%,and specificity 79%.Post-Kasai,mean liver stiffness was significantly higher in BA patients with varices than in patients without,with DOR 16.36,sensitivity 85%,and specificity 76%.Elastography differentiated stage F4 fibrosis from F0-F3 with DOR of 70.03,sensitivity 96%,and specificity 89%.Elastography also differentiated F3-F4 fibrosis from F0-F2 with DOR of 24.68,sensitivity 85%,and specificity 81%.CONCLUSION Elastography has potential as a non-invasive modality for BA diagnosis and surveillance post-Kasai.This paper’s limitations include inter-study method heterogeneity and small sample sizes.Future,standardized,multi-center studies are recommended. | Ellen S Wagner Hussien Ahmed H Abdelgawad Meghan Landry Belal Asfour Mark B Slidell Ruba Azzam | 2022 | World Journal of Gastroenterology2022，28，32： | 5 |
| 2 | Who wins the olympic games: economic resources and medals totals显示文摘 | BERNARD ANDREW B MEGHAN R BUSSE | 2004 | Rev Eco Statistics2004，86，1： | 1 |
| 3 | Delayed activation of insulin-like growth factor-1 recepor/Src/Mapk/kgr-1 signaling regulates clusterin expression a pro-survival factor显示文摘 | Tmcy C Meghan B Shinako A | 2005 | Biol Chem2005，280，14： | 1 |
| 4 | Delayed activation of insulin-like growth factor-1 recepor/Src/Mapk/kgr-1 signaling regulates clusterin expression a pro-survival factor显示文摘 | Tmcy C Meghan B Shinako A | 2005 | Biol Chem2005，280，14： | 1 |
| 5 | Long-TermEffects of Changing Land Use Practices on Surface Water Quality in aCoastal River and Lagoonal Estuary显示文摘 | Meghan B Rothenbeier JoAnn M Burkholder Cavell Brownie | 2009 | Environmental Management2009，44，： | 1 |
| 6 | Comparisons of stake- holder perceptions of tourism impacts in rural eastern North Carolina显示文摘 | Erick T B Holly E B Meghan G D | 2009 | Tourism Management2009，30，5： | 1 |
| 7 | Delayed activation of insulin-like growth factor-1 reeepor/Src/Mapk/kgr-1 signaling regulates clusterin expression a pro-survival factor显示文摘 | Tmcy C Meghan B Shinako A | | 0，，14： | 1 |
| 8 | Correlation of human T-cell lymphotropic virus type 1 (HTLV-Ι) mRNA with proviral DNA load,virus-specific CD8+T cells,and disease severity in HTLV-Ι-associated myelopathy(HAM/TSP)显示文摘 | YOSHIHISA Y MASAHIRO N MEGHAN B | 2002 | Blood2002，99，1： | 1 |
| 9 | Who Wins the Olympic Games:Economic Resources and Medal Totals显示文摘 | Bernard A B Meghan R B | 2004 | Review of Economic Statistics2004，86，1： | 1 |
| 10 | Comparisons Of Stakeholder Perceptions Of Tourism Impacts In Rural Eastern North Car- olina显示文摘 | Erick T B Holly E B Meghan G D | 2009 | Tourism Management2009，30，5： | 1 |
| 11 | Comparisons of stake- holder perceptions of tourism impacts in rural eastern North Carolina 显示文摘 | Erick T B Holly E B Meghan G D | 2009 | Tourism Management2009，30，5： | 1 |
| 12 | Delayed activation of insulin like growth factor-1 receptor/Src/Mapk/kgr-1 Singnaling regulates clustenin expression a pro-survival factor显示文摘 | Tmcy C Meghan B Shinako A | 2005 | Biol Chem2005，280，14： | 1 |
| 13 | The role of Raf kinase inhibitor protein(RKIP) in health and disease 显示文摘 | Evan TK Zheng F Meghan B | 2004 | Biol Pharm2004，68，6： | 1 |
| 14 | Delayed activation of insulin-like growth factor-1 receptor/Src/MAPK/Egr-1 signaling regulates clusterin expression,a pro -survival factor显示文摘 | Tracy C Meghan B Shinako A | 2005 | Biol Chem2005，280，14： | 1 |
| 15 | A com- parison of direct versus self-report measures for assessing phys- ical activity in adults: A systematic review显示文摘 | STEPHANIE A P KRISTI B A MEGHAN E H etal | 2008 | Inter J Behav Nutr and Phy2008，5，6： | 1 |
| 16 | Long-term effects of changing land use practices on surface water quality in a Coastal River and Lagoonal Estuary 显示文摘 | Meghan B R JoAnn M B Cavell B | 2009 | Environ Manage2009，44，3： | 1 |
| 17 | Who Wins the Olympic Games: Economic Resources and Medals Totals 显示文摘 | Bernard Andrew B Meghan R Busse | 2004 | Review of Economics and Statistics2004，86，1： | 1 |
| 18 | Comparisons of stakeholder perceptions of tourism impacts in rural eastern North Carolina 显示文摘 | Erick T B Holly E B Meghan G D | 2009 | Tourism Management2009，30，5： | 1 |
| 19 | Comparisons Of Stakeholder Perceptions Of Tourism Impacts In Rural Eastern North Carolina显示文摘 | Erick T B Holly E B Meghan G D | 2009 | Tourism Management2009，30，5： | 1 |
| 20 | Cognitive performance in centenarians and the oldest old:norms from the Georgia Centenarian Study显示文摘 | MILLER L S STEPHEN M MEGHAN B | 2010 | Neuropsychol Dev Cogn B Aging Neuropsychol Cogn2010，17，： | 1 |
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