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| 1 | Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a^(-/-) mice显示文摘AIM: To investigate the ability of a Prunella vulgaris(P. vulgaris) ethanolic extract to attenuate spontaneous typhlocolitis in mdr1a-/- mice. METHODS: Vehicle(5% ethanol) or P. vulgaris ethanolic extract(2.4 mg/d) were administered daily by oral gavage to mdr1a-/- or wild type FVBWT mice from 6 wk of age up to 20 wk of age. Clinical signs of disease were noted by monitoring weight loss. Mice experiencingweight loss in excess of 15% were removed from the study. At the time mice were removed from the study, blood and colon tissue were collected for analyses that included histological evaluation of lesions, inflammatory cytokine levels, and myeloperoxidase activity. RESULTS: Administration of P. vulgaris extracts to mdr1a-/- mice delayed onset of colitis and reduced severity of mucosal inflammation when compared to vehicle-treated mdr1a-/- mice. Oral administration of the P. vulgaris extract resulted in reduced(P < 0.05) serum levels of IL-10(4.6 ± 2 vs 19.4 ± 4), CXCL9(1319.0 ± 277 vs 3901.0 ± 858), and TNFα(9.9 ± 3 vs 14.8 ± 1) as well as reduced gene expression by more than two-fold for Ccl2, Ccl20, Cxcl1, Cxcl9, IL-1 α, Mmp10, VCAM-1, ICAM, IL-2, and TNFα in the colonic mucosa of mdr1a-/- mice compared to vehicle-treated mdr1a-/-mice. Histologically, several microscopic parameters were reduced(P < 0.05) in P. vulgaris-treated mdr1a-/-mice, as was myeloperoxidase activity in the colon(2.49 ± 0.16 vs 3.36 ± 0.06, P < 0.05). The numbers of CD4+ T cells(2031.9 ± 412.1 vs 5054.5 ± 809.5) and germinal center B cells(2749.6 ± 473.7 vs 4934.0 ± 645.9) observed in the cecal tonsils of P. vulgaris-treated mdr1a-/- were significantly reduced(P < 0.05) from vehicle-treated mdr1a-/- mice. Vehicle-treated mdr1a-/- mice were found to produce serum antibodies to antigens derived from members of the intestinal microbiota, indicative of severe colitis and a loss of adaptive tolerance to the members of the microbiota. These serum antibodies were greatly reduced or absent in P. vulgaris-treated mdr1a-/- mice. CONCLUSION: The anti-inflammatory activity of P. vulgaris ethanolic extract effectively attenuated the severity of intestinal inflammation in mdr1a-/- mice. | Kelley MK Haarberg Meghan J Wymore Brand Anne-Marie C Overstreet Catherine C Hauck Patricia A Murphy Jesse M Hostetter Amanda E Ramer-Tait Michael J Wannemuehler | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，4： | 8 |
| 2 | Systematic review of periprosthetic tibia fracture after total knee arthroplasties显示文摘AIM: To investigate the known incidences, treatment options, and related outcomes of periprosthetic tibia fractures after total knee arthroplasty(TKA).METHODS: A literature search was done to identify studies that fit the inclusion criteria. The database search yielded 185 results, which were further reduced by the exclusion criteria to 13 papers, totaling 157 patients that met these criteria. Incidence rates of the different types of periprosthetic tibia fractures were determined and their treatments were subsequently analyzed based on the fracture's subclass, with patient outcomes being overall favorable.RESULTS: Of the 144 documented patients, 54(37.5%) had a subclass C fracture, which are frequently seen in revision arthroplasties or when using cement intraoperatively. The fractures of subclasses A and B occur postoperatively. There were 90 subclass A and B fractures with incidences of 18.75% and 43.75% respectively. When broken down by type, 62(55.36%) were type 1, 24(21.4%) were type 2, 24(21.4%) were type 3, and 2(1.8%) were type 4. Furthermore, from the studies that included origin of injury, the types were further classified as having non-traumatic or traumatic origins. Type 1 had 78%(40/51) non-traumatic origin and 22%(11/51) traumatic origin. Fifteen fractures were type 2, but 5 were falls and 1 through a motor vehicle accident, giving a trauma causation of 40%(6/15). Of the 24 type 3 fractures, 12 were falls and 2 vehicular accidents, leading to a trauma causation of 58%(14/24).CONCLUSION: Type 1 fractures were the most common. Subclass A was treated with locking plates, B required a revision TKA, and C was treated intraoperatively or nonoperatively. | Nabil A Ebraheim Joseph R Ray Meghan E Wandtke Grant S Buchanan Chris G Sanford Jiayong LiuZ | 2015 | World Journal of Orthopedics2015，6，8： | 4 |
| 3 | Facile entry to the tetracyclic 5-7-6-3 tigliane ring system显示文摘 | Timo V Ovaska Sarah E Reisman Meghan A Flynn | 2001 | Org Lett2001，3，1： | 1 |
| 4 | Comparisons of stake- holder perceptions of tourism impacts in rural eastern North Carolina显示文摘 | Erick T B Holly E B Meghan G D | 2009 | Tourism Management2009，30，5： | 1 |
| 5 | Reactive sorption of chlorinated VOCs on ZSM-5 zeolites at ambient and elevated temperatures显示文摘 | MEGHAN E S HOWARD L G SYED Q | 2004 | Appl Catal B: Environ2004，52，2： | 1 |
| 6 | Diagenesis in porosity evolution of open- ing-mode fractures, Middle Triassic to Lower Jurassic La Boca Forma- tion, NE Mexico 显示文摘 | Stephen E L Meghan E W | 2006 | Tectonophysics2006，，419： | 1 |
| 7 | Comparisons Of Stakeholder Perceptions Of Tourism Impacts In Rural Eastern North Car- olina显示文摘 | Erick T B Holly E B Meghan G D | 2009 | Tourism Management2009，30，5： | 1 |
| 8 | The Role of guanine nucl-eotide exchange factor Tiam1 in cellular migration,invasion,adhesion and tumor progression显示文摘 | Meghan EM Lee-Su K Janet E | 2004 | Breast Cancer Research and Treatment2004，84，1： | 1 |
| 9 | Comparisons of stake- holder perceptions of tourism impacts in rural eastern North Carolina 显示文摘 | Erick T B Holly E B Meghan G D | 2009 | Tourism Management2009，30，5： | 1 |
| 10 | Evaluation of Silver Nanoparticle Toxicity in Skin in Vivo and Keratinocytes in Vitro显示文摘 | Samberg Meghan E Oldenburg Steven J Monteiro-Riviere Nancy A | 2010 | Environmental Health Perspectives2010，，3： | 1 |
| 11 | Mycobacterium tuberculosis 19-kDa lipoprotein inhibits IFN-γ-induced chromatin remodeling of MHC2TA by TLR2 and MAPK signaling显示文摘 | MEGHAN E P RISH K P DAVID C S | 2006 | J Immunol2006，176，8： | 1 |
| 12 | Extensive Gray Matter Volume Reduction in Treatment-Resis- tant Schizophrenia显示文摘 | Valerie M Anderson Meghan E Goldstein Robert R Kydd | 2015 | lnternational Journal of Neuropsychophar- macology2015，18，7： | 1 |
| 13 | Pulmonary hyper- tension in patients with chronic and end- stage kid- ney disease显示文摘 | Meghan E Sise Andrew M | 2013 | Kidney international2013，84，： | 1 |
| 14 | Importance of cell wall mannoproteins tbr septum formation in Saccharomyccs cerez,isiae 显示文摘 | Martin Schmidt Meghan E Strenk | 2005 | Yeast2005，22，9： | 1 |
| 15 | A com- parison of direct versus self-report measures for assessing phys- ical activity in adults: A systematic review显示文摘 | STEPHANIE A P KRISTI B A MEGHAN E H etal | 2008 | Inter J Behav Nutr and Phy2008，5，6： | 1 |
| 16 | High-Flow Nasal Cannula in a Mixed Adult ICU显示文摘 | Kristina A Gaunt Sarah K Spilman Meghan E Halub Julie A Jackson Keith D Lamb Sheryl M Sahr | 2015 | Respiratory Care2015，，10： | 1 |
| 17 | Comparisons of stakeholder perceptions of tourism impacts in rural eastern North Carolina 显示文摘 | Erick T B Holly E B Meghan G D | 2009 | Tourism Management2009，30，5： | 1 |
| 18 | Comparisons Of Stakeholder Perceptions Of Tourism Impacts In Rural Eastern North Carolina显示文摘 | Erick T B Holly E B Meghan G D | 2009 | Tourism Management2009，30，5： | 1 |
| 19 | Sport participation Motivation in Young Adolescent Girls:The Role of Friendship Quality and Self-Concept 显示文摘 | Meghan H McDonough Peter R E Crocker | 2005 | Research Quarterly for Exercise and Sport2005，76，： | 1 |
| 20 | Neural networks for prediction of acoustical properties of polyurethane foams显示文摘 | Glern C Gardner Meghan E O'Leary Scott Hansen | 2002 | Applied Acoustics2002，64，2： | 1 |
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