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| 1 | Non-invasive means of measuring hepatic fat content显示文摘Hepatic steatosis affects 20% to 30% of the general adult population in the western world. Currently, the technique of choice for determining hepatic fat deposition and the stage of fibrosis is liver biopsy. However, it is an invasive procedure and its use is limited, particularly in children. It may also be subject to sampling error. Non-invasive techniques such as ultrasound, computerised tomography (CT), magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (1H MRS) can detect hepatic steatosis, but currently cannot distinguish between simple steatosis and steatohepatitis, or stage the degree of fibrosis accurately. Ultrasound is widely used to detect hepatic steatosis, but its sensitivity is reduced in the morbidly obese and also in those with small amounts of fatty infiltration. It has been used to grade hepatic fat content, but this is subjective. CT can detect hepatic steatosis, but exposes subjects to ionising radiation, thus limiting its use in longitudinal studies and in children. Recently, magnetic resonance (MR) techniques using chemical shift imaging have provided a quantitative assessment of the degree of hepatic fatty infiltration, which correlates well with liver biopsy results in the same patients. Similarly, in vivo 1H MRS is a fast, safe, non-invasive method forthe quantification of intrahepatocellular lipid (IHCL) levels. Both techniques will be useful tools in future longitudinal clinical studies, either in examining the natural history of conditions causing hepatic steatosis (e.g. non-alcoholic fatty liver disease), or in testing new treatments for these conditions. | Sanjeev R Mehta E Louise Thomas Jimmy D Bell Desmond G Johnston Simon D Taylor-Robinson | 2008 | World Journal of Gastroenterology2008，14，22： | 21 |
| 2 | Natural history of macular status in recent-onset branch retinal vein occlusion:an optical coherence tomography study显示文摘 | Shroff D Mehta DK Arora R | 2008 | Int Ophthalmol2008，28，： | 1 |
| 3 | Turbulent boundary layer perturbed by a screen显示文摘 | Mehta R D | | 0，，： | 1 |
| 4 | 查看详情显示文摘 | Haynam C A Wegner P J Auerbach J M Bowers M W Dixit S N Erbert G V Heestand G M Henesian M A Hermann M R Jancaitis K S Manes K R Marshall C D Mehta N C Menapace J Moses E Murray J R Nostrand M C Orth C D Patterson R SacksR A Shaw M J Spaeth M Sutton S B W | | 0，，： | 1 |
| 5 | Mandibular Reconstruction in 2004: an Analysis of Different Techniques显示文摘 | Mehta R P Deschler D G | 2004 | Curr Opin Otolaryngol Head Neck Sury2004，12，4： | 1 |
| 6 | Intravascular ultrasound radiofrequeney analysis of coronary atherosclerosis:an emerging technology for the assessment of vulnerable plaque显示文摘 | Mehta S K McCrary J R Frutkin A D | 2007 | European Heart Journal2007，28，11： | 1 |
| 7 | Methicilin-resistant Staphylococcus aureus survival on hospital fomites 显示文摘 | Huang R Mehta S Weed D | 2006 | Infect Control Hosp Epidemiol2006，27，11： | 1 |
| 8 | Chemo paralysis for the re moval of a live intraocular worm in ocular angiostrongyliasis显示文摘 | Mehta DK Arora R Chauhan D | 2006 | ClinExperiment Ophthalmol2006，34，5： | 1 |
| 9 | The challenge of predicting field performance of air injection projects based on laboratory and numerical modeling显示文摘 | Gutierrez D Moore R G Mehta S A | 2009 | Journal of Canadian Petroleum Tech- nology2009，48，4： | 1 |
| 10 | The mierostructure and mechanical properties of friction stir welded AI-Zn-Mg alloy in as welded and heat treated conditions显示文摘 | SINGH R K SHARMA C DWIVEDI D K MEHTA N K KUMAR P | 2011 | Materials and Design2011，32，2： | 1 |
| 11 | Fluorinated proteins as potential 19F magnetic resonance imaging and spectroscopy agents显示文摘 | Mehta V D Kulkarni P V Mason R P etal | 1994 | Bioconiug Chem1994，5，3： | 1 |
| 12 | Improving outcomes from acute kidney injury: report of an initiative显示文摘 | Levin A Warnock D G Mehta R L | 2007 | Am J Kidney Dis2007，50，1： | 1 |
| 13 | Regulation of endothelial junctional permeability 显示文摘 | Vandenbroucke E Mehta D Minshall R | 2008 | Ann N Y Acad Sci2008，1123，： | 1 |
| 14 | The R&Dfactor in international trade and investment of UnitedStates 显示文摘 | Gruber W Mehta D Vemon R | 1967 | The Journal of Political Economy1967，75，1： | 1 |
| 15 | Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial显示文摘 | Shamir R Mehta Jean-Francois Tanguay John W Eikelboom Sanjit S Jolly Campbell D Joyner Christopher B Granger David P Faxon Hans-Jurgen Rupprecht Andrzej Budaj Alvaro Avezum Petr Widimsky Philippe Gabriel Steg Jean-Pierre Bassand Gilles Montalescot Carlos | 2010 | The Lancet2010，，9748： | 1 |
| 16 | Immunologic consequences of taurine deficiency in cats显示文摘 | Schuller-Levis G Mehta P D Rudelli R | 1990 | J Leukoc Biol1990，47，4： | 1 |
| 17 | Amniotic membrane transplantation inacute chemical bums显示文摘 | Arora R Mehta D Jain V | 2005 | Eye ( Lond)2005，19，： | 1 |
| 18 | Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial显示文摘 | Shamir R Mehta Jean-Francois Tanguay John W Eikelboom Sanjit S Jolly Campbell D Joyner Christopher B Granger David P Faxon Hans-Jurgen Rupprecht Andrzej Budaj Alvaro Avezum Petr Widimsky Philippe Gabriel Steg Jean-Pierre Bassand Gilles Montalescot Carlos | 2010 | The Lancet2010，，9748： | 1 |
| 19 | Incidence of and outcomes associated with ventricular tachycardia or fibrilla- tion in patients undergoing primary percutaneous coronary intervention 显示文摘 | Mehta R H Starr A Z Lopes R D | 2009 | JAMA2009，301，17： | 1 |
| 20 | LEDs-A Competitive Solution for General Lighting Applications显示文摘 | MEHTA R DESHPANDE D KULKARNI K | 2008 | IEEE Energy2008，，9： | 1 |
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