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	题名	作者	年代	出处	被引量
1	Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD.	Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao	2017	Bone Research2017，5，1：	9
2	Mutation analysis of autosomal dominant polycystic kidney disease genes in Han Chinese显示文摘	Zhang S Mei C Zhang D Dai B Tang B Sun T Zhao H Zhou Y Li L Wu Y Wang W Shen X Song J	2005	第二军医大学学报2005，26，8：	6
3	Computer modelling and tooling design for near net shaped components using hot isostatic pressing 显示文摘	YUAN W X MEI J SAMAROV V SELIVERSTOV D WU X	2007	Journal of Materials Processing Technology2007，182，123：	1
4	Reversible lithiumion storage in silve~treated nanoscale hollow porous silicon particles 显示文摘	D Y Chen X Mei G Ji	2012	Angewandte Chemic International Edition2012，51，10：	1
5	A Multiple Maximum Scatter Difference Discriminant Criterion for Facial Feature Extraction显示文摘	Song F X Zhang D Mei D Y		0，，：	1
6	On the water impact of general two-dimensional sections 显示文摘	Mei X Lui Y Yue D K P	1999	Applied Ocean Research1999，21，1：	1
7	Compositionally graded Ti6A14V/ TiC made by direct laser fabrication using powder and wire 显示文摘	Wang F D Mei J Wu X H	2007	Materials and Design2007，28，：	1
8	Environmental performance testing system for thermostructure materials applied in aeroengines显示文摘	Zhang L T Cheng L F Luan X G Mei H Xu Y D	2006	Key Eng Mat2006，313，：	1
9	Light - triggered reversible assemblies of an azobenzene - containing amphiphilic copolymer with 13 - cyclodextrin modified hollow mesoporous silica nanop- articles for controlled drug release 显示文摘	Mei X Yang S Chen D	2012	Chem Commun2012，48，10：	1
10	Direct laser fabrication of Ti6A14V/ TiB显示文摘	Wang F D Mei J Wu X H	2008	Journal of Materials Processing Technology2008，195，：	1
11	Optimization of dynamic parameters for a traction-type passenger elevator using a dynamic byte coding genetic algorithm显示文摘	MEI D DU X CHEN Z	2009	Journal of Mechanical Engineering Science2009，223，3：	1
12	Novel role of Zn (II) -curcumin inenhancing cell proliferation and adjusting proinflammatorycytokine-mediated oxidative damage of ethanol-inducedacute gastric ulcers 显示文摘	Mei X Xu D Xu S	2012	Chem Biol Interact2012，197，1：	1
13	Contrast enhancement based on a novel homogeneity measurement显示文摘	CHENG H D MEI X SHI X J	2003	Pattern Recognition2003，36，2：	1
14	Molybdenite Re-Os and albite 40Ar/39Ar dating of Cu-Au-Mo and magnetite porphyry systems in the Yangtze River valley and metallogenic implications显示文摘	Mao J W Wang Y T Lehmann Yu J J Du A D Mei Y X Li Y F Zang W S Stein H J and Zhou T F		0，，：	1
15	The Mg-ehelatase H subunit of Arabidopsis antagonizes a group of WRKY transcription repressors to relieve ABA-responsive genes of inhibition显示文摘	SHANG Y YAN L LIU Z Q CAO Z MEI C XIN Q WU F Q WANG X F DU S Y JIANG T ZHANG X F ZHAO R SUN H L LIU R YU Y T ZHANG D P	2010	Plant Cell2010，22，：	1
16	Reversible lithiumion storage in silver-treated nanoscale hollow porous silicon particles显示文摘	CHEN D MEI X JI G	2012	Angewandte Chemie International Edition2012，51，10：	1
17	显示文摘	ZHOU D MEI X OUYANG J	2011	J Phys Chem C2011，115，16：	1
18	Synthesis and gas sensing properties of hierarchical SnO2 nanostructures显示文摘	Sun P Mei X D Cai Y X	2013	Sensors Actuators B2013，187，：	1
19	Contrast enhancement based on a novel homogeneity measurement 显示文摘	Cheng H D Mei Xue Shi X J	2003	Pattern Recognition2003，11，36：	1
20	ZnO-based material,heterojunction and photoelctronic device显示文摘	Shen D Z Mei Z X Liang H L	2014	发光学报2014，，01：	1

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