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| 1 | Genetically engineered K cells provide sufficient insulin to correct hyperglycemia in a nude murine model显示文摘基因类型 1 糖尿病 mellitus 的基于治疗的处理要求能综合并且响应生理的联盟者分泌机能上地活跃的胰岛素的一个代理人贝它房间的发展在周围的葡萄糖层次的相关变化。在这研究,鼠科的 enteroendocrine 房间线 STC-1 被稳定的转染遗传上修改。二个克隆房间被选择(STC-1-2 和 STC-1-14 ) 那在从 0 ~ 157.2 亩 IU/ml/10 (6 ) cells/d 表示胰岛素的 22 克隆之中分泌了胰岛素的高水平。在在文化媒介的葡萄糖集中从 1 公里被增加到 10 公里以后,分泌胰岛素从 40.3 +/- 升起了 0.8 ~ 56.3 +/- 3.2 亩 IU/ml (STC-1-2 ) ,并且从 10.8 +/- 0.8 ~ 23.6 +/- 2.3 亩 IU/ml (STC-1-14 ) 。在 STC-1-14 房间被植入进糖尿病的裸体老鼠以后,他们的血葡萄糖层次被归结为正常。身体重量损失也被改善。我们的数据建议遗传上设计的 K 房间以一种调整葡萄糖的方式分泌活跃胰岛素,并且在 vivo,学习证明多糖症能被房间的培植颠倒,建议到快速的人的胰岛素力量的遗传上设计的 K 房间的使用提供一条调整葡萄糖的途径对待糖尿病的多糖症。 | Yiqun Zhang Liqing Yao Kuntang Shen Meidong Xu Pinghong Zhou Weige Yang Xinyuan Liu Xinyu Qin | 2008 | Acta Biochimica et Biophysica Sinica2008，40，2： | 4 |
| 2 | Micromechanics of substrate-supported thin films显示文摘The mechanical properties of metallic thin films deposited on a substrate play a crucial role in the performance of micro/nano-electromechanical systems(MEMS/NEMS)and flexible electronics. This article reviews ongoing study on the mechanics of substrate-supported thin films, with emphasis on the experimental characterization techniques,such as the rule of mixture and X-ray tensile testing. In particular, the determination of interfacial adhesion energy, film deformation, elastic properties and Bauschinger effect are discussed. | Wei He Meidong Han Shibin Wang Lin-An Li Xiuli Xue | 2018 | Acta Mechanica Sinica2018，34，2： | 2 |
| 3 | On the Loads for Strength Design of Cutterhead of Full Face Rock Tunnel Boring Machine显示文摘Cutterhead loads are the key mechanical parameters for the strength design of the full face hard rock tunnel boring machine(TBM).Due to the brittle rock-breaking mechanism,the excavation loads acting on cutters fluctuate strongly and show some randomness.The conventional method that using combinations of some special static loads to perform the strength design of TBM cutterhead may lead to strength failure during working practice.In this paper,a three-dimensional finite element model for coupled Cutterhead–Rock is developed to determine the cutterhead loads.Then the distribution characteristics and the influence factors of cutterhead loads are analyzed based on the numerical results.It is found that,as time changes,the normal and tangential forces acting on cutters and the total torque acting on the cutterhead approximately distribute log normally,while the total thrusts acting on the cutterhead approximately show a normal distribution.Furthermore,the statistical average values of cutterhead loads are proportional to the uniaxial compressive strength(UCS)of cutting rocks.The values also change with the penetration and the diameter of cutterhead following a power function.Based on these findings,we propose a three-parameter model for the mean of cutterhead loads and a method of generating the random cutter forces.Then the strength properties of a typical cutterhead are analyzed in detail using loads generated by the new method.The optimized cutterhead has been successfully applied in engineering.The method in this paper may provide a useful reference for the strength design of TBM cutterhead. | Meidong Han Zongxi Cai Chuanyong Qu | 2019 | Chinese Journal of Mechanical Engineering2019，32，6： | 2 |
| 4 | Functionalized Multiarm Poly(ε-caprolactone)s: Synthesis,structure analysis, and network formation显示文摘 | Meidong Lang Chih-Chang Chu | 2002 | J Appl Polym Sci2002，86，： | 1 |
| 5 | Preparation and properties of ZnO-based ceramic films for low-vohage va- ristors by novel sol-gel process显示文摘 | Huang Y Q Meidong L Yike Z | 2001 | Materials Science and Engineering: B2001，86，3： | 1 |
| 6 | Cationic poly(?-caprolactone) surface functionalized mesoporous silica nanoparticles and their application in drug delivery显示文摘 | Yan Zhang Zhaojun Wang Weimin Zhou Guoquan Min Meidong Lang | 2013 | Applied Surface Science2013，，： | 1 |
| 7 | Study on preparation and properties of carbon nanotubes/rubber composites显示文摘 | Yue Meidong Liu Yunfang Shen Zengmin | 2006 | Journal of Materials Science2006，41，8： | 1 |
| 8 | Abrasive wear characteristics of plasma sprayed nanostructared alumina-titania coatings显示文摘 | You Wang Stephen Jiang Meidong Wang | 2000 | Wear2000，237，： | 1 |
| 9 | Preparation and characterization of Ba1 - x SrxTiO3 thin films for uncooled infrared focal plane arrays 显示文摘 | Liu Shaobo Liu Meidong Zeng Yike | 2002 | Materials Science and Engineering C2002，22，： | 1 |
| 10 | Abrasive wear characteristios of plasma sprayed nunostructrued alumina/titania coatings显示文摘 | Wang You Jiang Stephen Wang Meidong | 2000 | Wear2000，237，： | 1 |
| 11 | Intravitreal Triamcinolone Prior to Laser Treatment of Diabetic Macular Edema显示文摘 | Mark C. Gillies Ian L. McAllister Meidong Zhu Wanling Wong Damien Louis Jennifer J. Arnold Tien Y. Wong | 2011 | Ophthalmology2011，，5： | 1 |
| 12 | Abrasive wear characteristics of plasma sprayed nanostructured almumina/titania coatings 显示文摘 | Wang You Jiang Stephen Wang Meidong | 2000 | Wear2000，237，： | 1 |
| 13 | Intravitreal Triamcinolone for Refractory Diabetic Macular Edema显示文摘 | Mark C. Gillies Florian K.P. Sutter Judy M. Simpson Jorgen Larsson Haipha Ali Meidong Zhu | 2006 | Ophthalmology2006，，9： | 1 |
| 14 | Molecular Simulation to Predict Miscibility and Phase Separation Behavior of Chitosan/Poly(?‐caprolactone) Binary Blends: A Comparison with Experiments显示文摘 | Chunhua Gu Huiyan Gu Meidong Lang | 2013 | Theory Simul2013，，7： | 1 |
| 15 | Synthesis and structural analysis of functionalized poly(ε-caprolactone)-based three-arm star polymers显示文摘 | Lang Meidong Wong R P Chu C C | 2002 | Journal of Polymer Science Part A: Polymer Chemistry2002，20，8： | 1 |
| 16 | Amber with mineral inclusions 显示文摘 | Li Haibo Lu Taijin Shen Meidong | 2010 | Gems & Gemology2010，46，4： | 1 |
| 17 | Fabrication and electrical properties of lead ziroconate titanate thick films using new Sol-Gel processing显示文摘 | Xia Donglin Liu Meidong Zeng Yike | 2001 | J Mat Sci2001，12，： | 1 |
| 18 | Abrasive wear characteristics of plasma sprayed nanostructured alumina/titania coatings显示文摘 | You Wang Stephen Jiang Meidong Wang | 2000 | Wear2000，237，： | 1 |
| 19 | Relation Between Reduction of Foveal Thickness and Visual Acuity in Diabetic Macular Edema Treated With Intravitreal Triamcinolone显示文摘 | J?rgen Larsson Meidong Zhu Florian Sutter Mark C. Gillies | 2005 | American Journal of Ophthalmology2005，，5： | 1 |
| 20 | Perioperative management and treatment for complications during and after peroral endoscopic myotomy (POEM) for esophageal achalasia (EA) (data from 119 cases)显示文摘 | Zhong Ren Yunshi Zhong Pinghong Zhou Meidong Xu Mingyan Cai Liang Li Qiang Shi Liqing Yao | 2012 | Surgical Endoscopy2012，，11： | 1 |
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