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| 1 | ESPEN营养风险筛选(NRS2002)——循证的方法及在欧洲的应用显示文摘 | Rémy Meier 陈凌(翻译) | 2007 | 中国临床营养杂志2007，15，1： | 17 |
| 2 | Measurement of calprotectin in ascitic fluid to identify elevated polymorphonuclear cell count显示文摘AIM: To evaluate the diagnostic capability of calprotectin in ascitic fluid for detecting a polymorphonuclear (PMN) cell count > 250/μL ascites. METHODS: In this prospective observational study, a total of 130 ascites samples were analysed from 71 consecutive patients referred for paracentesis. Total and differential leukocyte cell counts were determined manually with a Neubauer chamber and gentianviolet stain. Calprotectin was measured in 1 mL ascetic fluid by enzyme-linked immunosorbent assay (ELISA) and a point-of-care (POC) lateral flow assay with the Quantum Blue Reader (Bühlmann Laboratories). All measurements were carried out in a central laboratory by senior personnel blinded to patient history. A PMN count > 250/μL was the primary endpoint of the study. The diagnostic value of ascitic calprotectin measurement was assessed by comparing to the final diagnosis of each patient that had been adjudicated by investigators blinded to calprotectin values. RESULTS: The PMN count was > 250/μL in 19 samples (14.6%) from 15 patients (21.1%) and varied widely among the study population (range 10-19 800/mL and 1-17 820/mL, respectively). Spontaneous bacterial peritonitis (SBP) was the final diagnosis in four patients (5.6%). All patients with PMN ≤ 250/μL had negative bacterial culture. PMN count was elevated in five patients with peritoneal carcinomatosis, three with lymphoma, one with neuroendocrine carcinoma, and two with secondary peritonitis due to abdominal perforation. PMN cell counts correlated with ascitic calprotectin values (Spearman's rho; r = 0.457 for ELISA, r = 0.473 for POC). A considerable range of ascitic calprotectin concentrations was detected by ELISA [median 0.43 μg/mL, interquartile range (IQR) 0.23-1.23 (range 0.10-14.93)] and POC [median 0.38 μg/mL, IQR 0.38-0.56 (range 0.38-13.31)]. Ascitic calprotectin levels were higher in samples with PMN > 250/μL, by both ELISA [median (IQR) 2.48 μg/mL (1.61-3.65) vs 0.10 μg/mL (0.10-0.36), P < 0.001] and POC [2.78 μg/mL (2.05-5.37) vs 0.38 μg/mL (0.38-0.41), P < 0.001]. The area under the receiver operating characteristics curve for identifying an elevated PMN count was 0.977 (95%CI: 0.933 to 0.995) for ELISA and 0.982 (95%CI: 0.942 to 0.997) for POC (P = 0.246 vs ELISA). Using the optimal cut-off value for ELISA (0.63 μg/mL), ascitic calprotectin had 94.8% sensitivity, 89.2% specificity, positive and negative likelihood ratios of 8.76 and 0.06 respectively, positive and negative predictive values of 60.0% and 99.0% respectively, and 90.0% overall accuracy. Using the optimal cut-off value for POC (0.51 μg/mL), the respective values were 100.0%, 84.7%, 6.53, 0.00, 52.8%, 100% and 87.7%. Correlation between ELISA and POC was excellent (r = 0.873, P < 0.001). The mean ± SD of the difference was -0.11 ± 0.48 μg/mL with limits of agreement of + 0.8 μg/mL (95%CI: 0.69 to 0.98) and -1.1 μg/mL (95%CI: -1.19 to -0.91). CONCLUSION: Ascitic calprotectin reliably predicts PMN count > 250/μL, which may prove useful in the diagnosis of SBP, especially with a readily available bedside testing device. | Emanuel Burri Felix Schulte Jürgen Muser Rémy Meier Christoph Beglinger | 2013 | World Journal of Gastroenterology2013，19，13： | 10 |
| 3 | Device grade microcrystalline silicon owing to reduced oxygen contamination 显示文摘 | Meier J Luckige R F | 1996 | Appl Phys Lett1996，69，： | 1 |
| 4 | No benefit from combining HE4 and CA125 as ovarian tumor markers in a clinical setting 显示文摘 | Jacob F Meier M Caduff R | 2011 | Gynecol Oncol2011，121，3： | 1 |
| 5 | Distal radius fracturesretrospective quality control after conservative and operative therapy显示文摘 | Sommer C Brendebach L Meier R | 2001 | Swiss Surg2001，7，2： | 1 |
| 6 | The use of silymarin in the treatment of liver diseases 显示文摘 | Sailer R Meier R Brignoli R | 2001 | Drugs2001，61，14： | 1 |
| 7 | Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells显示文摘 | SCHRECK R MEIER B MANNEL D N | 1992 | J Exp Med1992，175，5： | 1 |
| 8 | Hemoglobin carbamylation in uremia显示文摘 | Fluckiger R Harmon W Meier W | 1981 | N Engl J Med1981，304，14： | 1 |
| 9 | Image processing: global and regional changes with age显示文摘 | Killiany R J Meier D S Guttmann C R | 2004 | Top Magn Reson Imaging2004，15，6： | 1 |
| 10 | Vascular anatomy of the gastric tube used for esophageal reconstruction显示文摘 | LIEBERMANN MEFFERT D M MEIER R SIEWERT J R | 1992 | Ann Thorac Surg1992，54，6： | 1 |
| 11 | Introductory to the ESPEN guidelines in enteral nutrition: terminology, definitions and general topics显示文摘 | Lochs H Allison SP Meier R | 2006 | Clin Nutr2006，25，2： | 1 |
| 12 | Mechanisms controlling the durability of thermal barrier coatings显示文摘 | EVANS A G MUMM D R HUTCHINSON J W MEIER G H Pettit F S | 2001 | Progress in Materials Science2001，46，5： | 1 |
| 13 | Adenosine minetics as in- hibitors of NAD--denpendent histone deacetylases, from ki- nase to sirtuin inhibition 显示文摘 | Trapp J JochumA Meier R | 2006 | J ivied Chem2006，49，25： | 1 |
| 14 | Unexpected high com- plication rate following internal fixation of unstable proximal humerus fractures with an angled blade pate显示文摘 | Meier R A Messmer P Regazzoni P | 2006 | J Orthop Trauma2006，20，4： | 1 |
| 15 | Fam83A confers EGFR-TKI resistance in breast cancer cells and in mice显示文摘 | Lee SY Meier R Furuta S | 2012 | J Clin Invest2012，122，9： | 1 |
| 16 | ESPEN Guidelines on Enteral Nutrition:Pancreas显示文摘 | Meier R Ockenga J Pertkiewicz M | 2006 | Clin Nutr2006，25，2： | 1 |
| 17 | Optimal control of measurement subsystems显示文摘 | Meier L Peschon J Dressier R | 1967 | IEEE Transactions on Automatic Control1967，12，5： | 1 |
| 18 | Pancreatic diabetes manifests when beta cell area declines by approximately 65% in humans显示文摘 | MEIER J J BREUER T G BONADONNA R C | 2012 | Diabetologia2012，55，5： | 1 |
| 19 | Omeprazole, other antiulcer drugs and newly diagnosed gout显示文摘 | MEIER C R JICK H | 1997 | British Journal of Clinical Pharma- cology1997，44，2： | 1 |
| 20 | A spurious jump in the satellite record : has Antarctic sea ice expansion been overestimated? 显示文摘 | Eisenman I Meier W N Norris J R | 2014 | Cryosphere2014，8，4： | 1 |
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