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您的检索式：作者名="Meihong Lai"
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| 1 | Investigation on the Performance of the Pump-Free Double Heat Source Ejector Refrigeration System with R1234yf显示文摘A pump is needed in an ejector refrigeration system,which makes the system high cost and complicated and hinders its application.A pump-free double heat source ejector refrigeration system using R1234yf as working fluid is proposed in which an injector driven by another heat source replaces the liquid circulating pump,making the system more affordable,simpler and more stable.The effect of different operation conditions on entrainment ratios and the influence of different factors on system performance are analyzed on the basis of mass,momentum and energy conservation equations.The influence degree of each factor on system performance is investigated by the orthogonal test method.The condenser temperature has the largest effect on system performance.The pressure drop in the suction chamber of gas-liquid injector has the least impact on system performance.The COP can reach about 0.35 under a certain working condition.The system can be driven by two different temperature heat sources with no electricity needed,and it is a good choice for places with abundant heat resources or lack of electricity. | YU Meihong ZHAO Hongxia WANG Xinli HAN Jitian LAI Yanhua | 2022 | Journal of Thermal Science2022，31，5： | 0 |
| 2 | Protective eff ect and mechanism of nanoantimicrobial peptide ND-C14 against Streptococcus pneumoniae infection显示文摘BACKGROUND:Streptococcus pneumoniae(S.pneumoniae)is a common pathogen that causes bacterial pneumonia.However,with increasing bacterial resistance,there is an urgent need to develop new drugs to treat S.pneumoniae infections.Nanodefensin with a 14-carbon saturated fatty acid(ND-C14)is a novel nanoantimicrobial peptide designed by modifying myristic acid at the C-terminus of humanα-defensin 5(HD5)via an amide bond.However,it is unclear whether ND-C14 is effective against lung infections caused by S.pneumoniae.METHODS:In vitro,three groups were established,including the control group,and the HD5 and ND-C14 treatment groups.A virtual colony-count assay was used to evaluate the antibacterial activity of HD5 and ND-C14 against S.pneumoniae.The morphological changes of S.pneumoniae treated with HD5 or ND-C14 were observed by scanning electron microscopy.In vivo,mice were divided into sham,vehicle,and ND-C14 treatment groups.Mice in the sham group were treated with 25μL of phosphate-buffered saline(PBS).Mice in the vehicle and ND-C14 treatment groups were treated with intratracheal instillation of 25μL of bacterial suspension with 2×108 CFU/mL(total bacterial count:5×10^(6) CFU),and then the mice were given 25μL PBS or intratracheally injected with 25μL of ND-C14(including 20μg or 50μg),respectively.Survival rates were evaluated in the vehicle and ND-C14 treatment groups.Bacterial burden in the blood and bronchoalveolar lavage fluid were counted.The lung histology of the mice was assessed.A propidium iodide uptake assay was used to clarify the destructive eff ect of ND-C14 against S.pneumoniae.RESULTS:Compared with HD5,ND-C14 had a better bactericidal eff ect against S.pneumoniae because of its stronger ability to destroy the membrane structure of S.pneumoniae in vitro.In vivo,ND-C14 significantly delayed the death time and improved the survival rate of mice infected with S.pneumoniae.ND-C14 reduced bacterial burden and lung tissue injury.Moreover,ND-C14 had a membrane permeation eff ect on S.pneumoniae,and its destructive ability increased with increasing ND-C14 concentration.CONCLUSION:The ND-C14 may improve bactericidal eff ects on S.pneumoniae both in vitro and in vivo. | Yangyang Guo Yaqi Sun Hongxia Wu Jian Lu Yuan Lin Jiaqing Zhu Meihong Lai Meiqi Zhang Jun Wang Jungang Zheng | 2024 | World Journal of Emergency Medicine2024，15，1： | 0 |
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