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| 1 | Ginkgo biloba extract improved cognitive and neurological functions of acute ischaemic stroke:a randomised controlled trial显示文摘Purpose To evaluate the efficacy and safety of Ginkgo biloba extract(GBE)in acute ischaemic stroke and its impact on the recurrence of vascular events.Methods We conducted a multicentre,prospective,randomised,open label,blinded,controlled clinical trial enrollingpatients with an onset of acute stroke within 7 days from five hospitals in China Jiangsu Province.Participants were assigned to the GBE group(450 mg GBE with 100 mg aspirin daily)or the control group(100 mg aspirin daily)for 6 months.The primary outcome was the decline in the Montreal Cognitive Assessment score at 6 months.Secondary outcomes were other neuropsychological tests of cognitive and neurological function,the the incidence of adverse events and vascular events.results 348 patients were enrolled:179 in the GBE group and 169 in the control group.With 18 patients lost to follow-up,the dropout rate was 5.17%.Admission data between two groups were similar,but in the GBE group there was a marked slow down in the decline in the Montreal Cognitive Assessment scores(−2.77±0.21 vs−1.99±0.23,P=0.0116(30 days);−3.34±0.24 vs−2.48±0.26,P=0.0165(90 days);−4.00±0.26 vs−2.71±0.26,P=0.0004(180 days))compared with controls.The National Institutes of Health Stroke Scale scores at 12 and 30 days,the modified Rankin Scale scores for independent rate at 30,90 and 180 days,and the Barthel Index scores at 30,90 and 180 days in the GBE group were significantly improved compared with controls.Improvements were also observedin GBE groups for Mini-Metal State Examination scores of 30,90 and 180 days,Webster's digit symbol test scores at 30 days and Executive Dysfunction Index scores at 30 and 180 days.No significant differences were seen in the incidence of adverse events or vascular events.conclusions We conclude that GBE in combination with aspirin treatment alleviated cognitive and neurological deficits after acute ischaemic stroke without increasing the incidence of vascular events. | Shanshan Li Xinjiang Zhang Qi Fang Junshan Zhou Meijuan Zhang Hui Wang Yan Chen Biyun Xu Yanfeng Wu Lai Qian Yun Xu | 2017 | Stroke & Vascular Neurology2017，2，4： | 25 |
| 2 | Research progress on synergistic anti-tumor mechanisms of compounds inTraditional Chinese Medicine显示文摘The curative effects of Chinese herbal compounds result from the coordination of numerous natural compounds.We aimed to review the mechanism of action of Traditional Chinese Medicine(TCM)compounds(TCMC),explore the rationality of formulation theory and synergistic effects in TCM compounds,and analyze the effectiveness of drug compatibility of TCMC in molecular biology.This literature review covers the mechanisms of the anti-tumor effects of compounds,and their synergistic antitumor mechanisms.We aim to provide reference for the effective development and use of natural resources and the organic combination of TCM and modern medicine using molecular biology. | Jing Zhou Tianyao Zhou Meijuan Chen Miao Jiang Xiaoxia Wang Qin Liu Zhen Zhan Xu Zhang | 2014 | Journal of Traditional Chinese Medicine2014，34，1： | 15 |
| 3 | Factors Associated with Thrombolysis Outcome in Ischemic Stroke Patients with Atrial Fibrillation显示文摘The outcome of early intravenous thrombolysis for ischemic stroke in patients with atrial fibrillation(AF)is worse than that without thrombosis. How to increase the efficacy of intravenous thrombolysis for AF-related ischemic stroke remains largely unknown. In this study, we investigated factors that influence the effect of intravenous thrombolysis in these patients. Our results showed that thrombolysis was independently associated with a favorable outcome(P \ 0.001) and did not influence the mortality of AF-related ischemic stroke, although it increased the risk of hemorrhage within 24 h after treatment. Risk factors for a poor outcome at admission were:heart failure(P = 0.045); high systolic pressure(P = 0.039); high blood glucose(P = 0.030); and a high National Institutes of Health Stroke Scale(NIHSS) score(P \ 0.001). Moreover, high systolic pressure at admission(P = 0.007), high blood glucose(P = 0.027), and a high NIHSS score(P \ 0.001) were independent risk factors for mortality at 3 months. Besides thrombolysis, a high NIHSS score(P = 0.006) and warfarin taken within 48 h before stroke onset(P = 0.032) were also independent risk factors for symptomatic hemorrhage within 24 h after treatment. Ischemic stroke patients with AF benefited from intravenous thrombolysis with recombinant tissue plasminogen activator within 4.5 h after stroke. | Qiuyun Zhao Xiaobo Li Wanli Dong Min Ye Yongjun Cao Meijuan Zhang Qiantao Cheng Junshan Zhou Guofang Chen Ming Yu Shanshan Hong Xiue Wei Bei Wang Guiyun Cui Peng Zhang Hong Ding Rongzhen Xu Yan Chen Yun Xu | 2016 | Neuroscience Bulletin2016，32，2： | 13 |
| 4 | Hydrogen Sulfide Positively Regulates Abscisic Acid Signaling through Persulf idation of SnRK2.6 in Guard Cells显示文摘The phytohormone abscisic acid(ABA)plays pivotal roles in triggering stomatal closure and facilitating adaptation of plants to drought stress.Hydrogen sulfide(H2S),a small signaling gas molecule,is involved in ABA-dependent stomatal closure.However,how H2S regulates ABA signaling remains largely unclear.Here,we show that ABA induces the production of H2S catalyzed by L-CYSTEINE DESULFHYDRASE1(DES1)in guard cells,and H2S in turn positively regulates ABA signaling through persulfidation of Open Stomata 1(OST1)/SNF1-RELATED PROTEIN KINASE2.6(SnRK2.6).Two cysteine(Cys)sites,Cys131 and Cys137,which are exposed on the surface of SnRK2.6 and close to the activation loop,were identified to be persulfidated,which promotes the activity of SnRK2.6 and its interaction with ABA response element-binding factor 2(ABF2),a transcription factor acting downstream of ABA signaling.When Cys131,Cys137,or both residues in SnRK2.6 were substituted with serine(S),H2S_induced SnRK2_6 activity and SnRK2.6-ABF2 interaction were partially(SnRK2.6c131s and SnRK2.6c137S)or completely(SnRK2.6c131sc137S)compromised.Introduction of SnRK2.6c131s,SnRK2.6c137S,or SnRK2.6c131sc137S into the ost1-3 mutant could not rescue the mutant phenotype:less sensitivity to ABA-and H2S-induced stomatal closure and Ca2+influx as well as increased water loss and decreased drought tolerance.Taken together,our study reveals a novel post-translational regulatory mechanism of ABA signaling whereby H2S persulfidates SnRK2.6 to promote ABA signaling and ABA-induced stomatal closure. | Sisi Chen Honglei Jia Xiaofeng Wang Cong Shi Xiao Wang Peiyun Ma Juan Wang Meijuan Ren Jisheng Li | 2020 | Molecular Plant2020，13，5： | 13 |
| 5 | Electroacupuncture reduces injury to the blood-brain barrier following cerebral ischemia/reperfusion injury显示文摘This study used electroacupuncture at Renzhong (DU26) and Baihui (DU20) in a rat model of cerebral ischemia/reperfusion injury. Neurological deficit scores, western blotting, and reverse transcription-PCR results demonstrated that electroacupuncture markedly reduced neurological deficits, decreased corpus striatum aquaporin-4 protein and mRNA expression, and relieved damage to the blood-brain barrier in a rat model of cerebral ischemia/reperfusion injury. These results suggest that electroacupuncture most likely protects the blood-brain barrier by regulating aquaporin-4 expression following cerebral ischemia/reperfusion injury. | Yongjun Peng Hesheng Wang Jianhua Sun Li Chen Meijuan Xu Jihong Chu | 2012 | Neural Regeneration Research2012，7，36： | 6 |
| 6 | Differences in P50 and prepulse inhibition of the startle reflex between male smokers and non-smokers with first episode schizophrenia without medical treatment显示文摘 | Song Lisheng Chen Xingshi Chen Meijuan Tang Yunxiang Wang Jijun Zhang Mingdao Lou Feiying Liang Jianhua Chen Chong | 2014 | Chinese Medical Journal2014，，9： | 6 |
| 7 | Effect of fructooligosaccharides on the colonization of Lactobacillus rhamnosus AS 1.2466^(T) in the gut of mice显示文摘Lactobacillus rhamnosus and fructooligosaccharides(FOS)have been widely studied so far.However,the effects of L.rhamnosus on the intestinal microecological environment at the species level and the effect of different proportions of FOS on L.rhamnosus colonization in different parts of mice intestine are still unclear.The study results indicated that the specific bands of enterobacterial repetitive intergenic consensus polymerase chain reaction(ERIC-PCR)in the L.rhamnosus(LR)group significantly increased at 7 days.Although the number of bands was similar to the natural recovery(NR)group,the brightness of few bands significantly enhanced in the later stage of recovery.Besides,Southern-blot maps showed strong signals,indicating that the ERIC-PCR fingerprint could accurately reflect the changes in the mouse gut microbiota diversity.Further,the high-throughput results confirmed that the Lactobacillus and Akkermansia had different changes at different periods,but all of them showed an upward trend,while the Klebsiella were inhibited,thereby maintaining the intestinal microecology balance.Moreover,FOS exerted a positive effect on L.rhamnosus colonization in the gut. | Zhihua Niu Meijuan Zou Tingting Bei Na Zhang Dongyao Li Miaoshu Wang Chen Li Hongtao Tian | 2023 | Food Science and Human Wellness2023，12，2： | 3 |
| 8 | Differential display of carrot radicle genes in different developmental states显示文摘mRNA differential display was used in analyzing the expression of carrot somatic embryo radicle gene in different developmental stages brought about by controlled cultivation. As shown by experiment, marked differences in electrophoresis patterns of DNA exist between the normally developing carrot radicle and those with their development inhibited. 12 series of specific bands have been cloned, and structural analysis of them is under way. | Chunxia Chen Meijuan Huang Hao Liu Naihu Wu | 1998 | Chinese Science Bulletin1998，43，15： | 3 |
| 9 | IFN-inducible p47 GTPases display differential responses to Schistosoma japonicum acute infection显示文摘Interferon gamma induced GTPase(IGTP)(also named lrgm3)and interferon gamma inducible protein 47(IRG-47)(also named lIrgd)are interferon(IFN)-inducible p47 GTPases that have been shown to regulate host resistance to intracellular pathogens.Little knowledge has been known about the role of p47 GTPases in host responses against extracellular pathogens.To investigate possible roles of IGTP and IRG-47 in the course of Schistosoma japonicum infection,IGTP and IRG-47 knockout and wild-type(WT)mice were challenged with cercariae of S.japonicum,and host responses were analyzed.At the acute stage of S.japonicum infection,mice that lacked IGTP displayed similar parasite burden and pathological damage to WT mice.Importantly,S.japonicum-infected lRG-47-deficient mice,in contrast to IGTP-deficient mice and WT mice,showed significantly reduced worms and lower egg-burden,but intense granulomatous reaction evoked by schistosome eggs in peripheral parts of liver lobes.In addition,upregulation of inflammation-related gene expression was observed in the spleen of IRG-47-deficient mice using oligonucleotide microarrays,in which multiple pathways of cytokine-cytokine receptor interaction,T-cell receptor signaling,complement,coagulation cascades and cell adhesion molecules were highlighted.Taken together,these data suggest that IGTP and IRG-47 might have distinct features that were differentially required for resistance to S.japonicum. | Xuesong Chen Xiaotang Du Meijuan Zhang Donghui Zhang Minjun Ji Guanling Wu | 2010 | Cellular & Molecular Immunology2010，7，1： | 2 |
| 10 | Hydroxysafflor yellow A suppresses inflammatory responses of BV2 microglia after oxygen–glucose deprivation显示文摘 | Jie Li Shenyang Zhang Mengru Lu Zhibin Chen Cong Chen Lijuan Han Meijuan Zhang Yun Xu | 2013 | Neuroscience Letters2013，，： | 2 |
| 11 | Association of assisted reproductive technology, germline de novo mutations and congenital heart defects in a prospective birth cohort study显示文摘Emerging evidence suggests that children conceived through assisted reproductive technology(ART)have a higher risk of congenital heart defects(CHDs)even when there is no family history.De novo mutation(DNM)is a well-known cause of sporadic congenital diseases;however,whether ART procedures increase the number of germline DNM(gDNM)has not yet been well studied.Here,we performed whole-genome sequencing of 1137 individuals from 160 families conceived through ART and 205 families conceived spontaneously.Children conceived via ART carried 4.59 more gDNMs than children conceived spontaneously,including 332 paternal and 1.26 maternal DNMs,after correcting for parental age at conception,cigarette smoking,alcohol drinking,and exercise behaviors.Paternal DNMs in offspring conceived via ART are characterized by C>T substitutions at CpG sites,which potentially affect protein-coding genes and are significantly associated with the increased risk of CHD.In addition,the accumulation of non-coding functional mutations was independently associated with CHD and 87.9% of the mutations were originated from the father.Among ART offspring,infertility of the father was associated with elevated paternal DNMs;usage of both recombinant and urinary follicle-stimulating hormone and high-dosage human chorionic gonadotropin trigger was associated with an increase of maternal DNMs.In sum,the increased gDNMs in offspring conceived by ART were primarily originated from fathers,indicating that ART itself may not be a major reason for the accumulation of gDNMs.Our findings emphasize the importance of evaluating the germline status of the fathers in families with the use of ART. | Cheng Wang Hong Lv Xiufeng Ling Hong Li Feiyang Diao Juncheng Dai Jiangbo Du Ting Chen Qi Xi Yang Zhao Kun Zhou Bo Xu Xiumei Han Xiaoyu Liu Meijuan Peng Congcong Chen Shiyao Tao Lei Huang Cong Liu Mingyang Wen Yangqian Jiang Tao Jiang Chuncheng Lu Wei Wu Di Wu Minjian Chen Yuan Lin Xuejiang Guo Ran Huo Jiayin Liu Hongxia Ma Guangfu Jin Yankai Xia Jiahao Sha Hongbing Shen Zhibin Hu | 2021 | Cell Research2021，31，8： | 2 |
| 12 | Biological mechanism study of meditation and its application in mental disorders显示文摘In recent years,research on meditation as an important alternative therapy has developed rapidly and been widely applied in clinical medicine.Mechanism studies of meditation have also developed progressively,showing that meditation has great impact on brain structure and function,and epigenetic and telomere regulation.In line with this,the application of meditation has gradually been expanded to mental illness,most often applied for major depressive disorders and substance-related and addictive disorders.The focus of this paper is to illustrate the biological mechanisms of meditation and its application in mental disorders. | Hui Shen Meijuan Chen Donghong Cui | 2020 | General Psychiatry2020，33，4： | 2 |
| 13 | Increasing Fatty Acids in Rice Root Improves Silence of Rice Seedling to Salt Stress显示文摘Salt stress is one of the major abiotic stresses around the world, and salt salinity is one of the major constrains affecting rice production (Tu et al, 2014;Reddy et al, 2017). According to the statistics, more than one billion hectares of the land in the major continents are affected by salinity (Fageria et al, 2012;Zhou et al, 2018). Rice is a salt sensitive crop, considered more sensitive to salt stress during early stage (Hasanuzzaman et al, 2009). Understanding the method to improve plant salt tolerance is a potential way to enhance agriculture productivity in the future (Jing and Zhang, 2017). Polyunsaturated fatty acid (PUFA) on plasma membrane plays important roles in salt tolerance through enhancing the activity of Na^+/H^+ transporters (López-Pérez et al, 2009). | LIU Ling CHEN Jin TAN Yanning ZHOU Tianshun OUYANG Ning ZENG Jia YUAN Dingyang DUAN Meijuan | 2019 | Rice science2019，26，6： | 2 |
| 14 | A bZIP transcription factor, OsABI5, is involved in rice fertility and stress tolerance显示文摘 | Meijuan Zou Yucheng Guan Haibo Ren Fang Zhang Fan Chen | 2008 | Plant Molecular Biology2008，，6： | 1 |
| 15 | Fast mode decision algorithm through inter-view rate-distortion predic- tion for muhiview video coding system显示文摘 | Yeh Chia-Hung Li Mingfeng Chen Meijuan | 2014 | IEEE Transac- tions on Industrial Informatics2014，10，1： | 1 |
| 16 | HSP27,70and90,anti-apoptoticproteins,in clinicalcancertherapy(Review)显示文摘 | WangXiaoxia Chen Meijuan ZhouJing etal | 2014 | IntJOncol2014，45，1： | 1 |
| 17 | HSP27 ,70and 90,anti-apoptotic proteins,in clinical cancer therapy显示文摘 | Wang Xiaoxia Chen Meijuan Zhou Jing | 2014 | Int J Oncol2014，45，1： | 1 |
| 18 | Elevated expression of CAPON and neuronal nitric oxide synthase in the sciatic nerve of rats following constriction injury显示文摘 | Zhiming Cui Qingshan Lv Meijuan Yan Chun Cheng Zhiqin Guo Junling Yang Mengling Chen Yinyin Xia Li Zhang Aiguo Shen | 2010 | The Veterinary Journal2010，，3： | 1 |
| 19 | Entecavir and lamivudine therapy for severe acute chronic hepatitisB显示文摘 | Changhong Liu Jing Ye Hongyu Jia Meijuan Zhang Hongfeng Han Fengzhe Chen Congkang Chen | 2013 | Experimental and Therapeutic Medicine2013，，2： | 1 |
| 20 | Efforts to-wards gaining a better understanding of the remote field显示文摘 | Meijuan Chen Yang Zhao | 1996 | IEEE Transaction on Magnetics1996，32，3： | 1 |
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