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| 1 | Effect of Qilongtoutong granule on calcitonin gene-related peptide,beta-endorphin, serotonin, dopamine, and noradrenalin in migraine model rats and mice显示文摘OBJECTIVE: To study the effect of Qilongtoutong granule(QLTT) on plasma calcitonin gene-related peptide(CGRP), beta-endorphin(β-EP), 5-HT, dopamine(DA), noradrenalin(NE), and blood viscosity in migraine model rats and mice.METHODS: Both the acute blood stasis model group and nitroglycerin-induced migraine model group included 60 Sprague-Dawley rats. The reserpine-reduced model group had 60 Kunming mice.Rats from each test were grouped into normal control group, model group, Zhengtian pill(ZTP)group, and high, moderate, or low-dose QLTT groups. In the acute blood stasis model test, after gavage for 7 days, rats were given 0.8 mL/kg adrenaline hydrochloride subcutaneously twice, and kept in ice water for 5 min. After fasting for 12 h,rats were anesthetized and blood samples were col-lected for detection of blood viscosity. In the nitroglycerin-induced migraine group, after gavage for7 days, rats were intraperitoneally injected nitroglycerin(10 mg/kg), and 4 h later, blood samples were collected from postcava for measuring the plasma CGRP and β-EP levels. In the reserpine-reduced model test, except the normal control group, mice were administered reserpine(0.25 mg/kg, i.h.) for 9 days. Mice received intragastric administration from the third day to the ninth day. One hour after the last gavage, blood and brain tissue samples were obtained. Then, blood clotting time and the contents of neurotransmitters were determined.RESULTS: QLTT-(3.6, 1.8, and 0.9 g/kg) and ZTP-treated rats had lower blood viscosity than that in model rats under different shear rates(P<0.01). QLTT-(3.6, 1.8 g/kg) and ZTP-treated rats had significantly lower plasma CGRP levels and higher plasma β-EP levels than those in model rats(P<0.01). QLTT treatment at dose of 0.9 g/kg had lower plasma CGRP levels as well(P<0.05). QLTT-(5.2,2.6 g/kg) and ZTP-treated mice had longer blood clotting time than that in model mice(P<0.01).QLTT-(2.6 g/kg) and ZTP-treated mice had higher plasma serotonin(5-HT) levels than those in model mice(P<0.05).CONCLUSION: QLTT-treated animals had lower plasma CGRP level, higher plasma β-EP, 5-HT, higher brain tissue 5-HT, NE, DA levels, and lower blood viscosity than those in the migraine model animals. | Xiaofang Wu Meikui Zhang Huai Huang | 2014 | Journal of Traditional Chinese Medicine2014，34，2： | 9 |
| 2 | Effects of transcranial direct current stimulation on language improvement and cortical activation in nonfluent variant primary progressive aphasia显示文摘 | Jie Wang Dongyu Wu Yan Chen Ying Yuan Meikui Zhang | 2013 | Neuroscience Letters2013，，： | 1 |
| 3 | Design of a search and rescue terminal based on the dual-mode satellite and CDMA network显示文摘The current goal is to create a set of portable terminals with GPS/BD2 dual-mode satellite positioning, vital signs monitoring and wireless transmission functions. The terminal depends on an ARM processor to collect and combine data related to vital signs and GPS/BD2 location information, and sends the message to headquarters through the military CDMA network. It integrates multiple functions as a whole. The satellite positioning and wireless transmission capabilities are integrated into the motherboard, and the vital signs sensors used in the form of belts communicate with the board through Bluetooth. It can be adjusted according to the headquarters' instructions. This kind of device is of great practical significance for operations during disaster relief, search and rescue of the wounded in wartime, non-war military operations and other special circumstances. | ZHAO JunPing 1* , ZHANG Xuan 2 , ZHENG Bing 1 , ZHOU YuBin 3 , SONG Hao 2 , SONG Wei 2 , ZHANG MeiKui 1 , LIU TongZe 1 & ZHOU Li 1 1 Institute of Medical Informatics, General Hospital of PLA, Beijing 100853, China 2 Beijing Aerospace Science & Industry Century Satellite Hi-Tech Co. Ltd., Beijing 100070, China 3 Institute of Aviation Medicine, Beijing 100842, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，12： | 0 |
| 4 | Bidirectional Benign Regulation of Acupuncture in the Treatment of Stroke显示文摘Acupuncture is a traditional Chinese medicine therapy originated in China.In recent years,acupuncture is widely used in the field of neurological diseases,especially in the acute stage of stroke.Its mechanism of action is becoming clearer;one of the possible mechanisms is its bidirectional benign regulation. | Long He Honglong Wu Anlai Liu Meikui Zhang | 2021 | Proceedings of Anticancer Research2021，5，6： | 0 |
| 5 | Research Progress on the Neuroprotective Effect of Leonurine on Ischemic Stroke显示文摘Leonurus is one of the commonly used clinical drugs in traditional Chinese medicine.In recent years,leonurus has been widely used for cerebrovascular diseases.With the deepening of research,the effect of its main component,leonurine,on the central nervous system has become clearer,and its mechanism has been confirmed and explained from many aspects.For reference,this paper discusses the latest research on the neuroprotective effect of leonurine on ischemic stroke at home and abroad in recent years. | Honglong Wu Long He Zhifen Tan Meikui Zhang | 2021 | Proceedings of Anticancer Research2021，5，6： | 0 |
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