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| 1 | Protective effects of a new metalloporphyrin on paraquat-induced oxidative stress and apoptosis in N27 cells显示文摘Paraquat (PQ, 1,1'-dimethyl-4,4'-bipyridinium ) ,使用得广泛地的除草剂,为 Parkinson 的疾病的发展作为一个潜在的 etiologic 因素被建议了。在最近的年里,许多研究集中于 PQ neurotoxicity 的机制。在这研究,我们检验了锰( III )的 neuroprotective 效果 meso-tetrakis ( N , N'-diethylimidazolium )卟啉( MnTDM ),超级氧化物 dismutase/catalase 模仿,在在 1RB ( 3 )的 导致PQ 的氧化应力和 apoptosis 上一( 27 )( N27 )房间,一根 dopaminergic neuronal 房间线。结果显示 MnTDM 显著地稀释了房间生存能力,谷胱甘肽弄空,和反应的氧种类生产的导致 PQ 的损失。MnTDM 也改善了 apoptosis 的导致 PQ 的词法原子变化和 apoptosis 的增加的率。另外,我们的数据提供 MnTDM 压制了导致 PQ 的 caspase-3 劈开的直接证据,可能 PQ neurotoxicity 的一个关键事件。这些观察建议了那个氧化压力, apoptosis 在导致 PQ 的 neurotoxicity 被含有,这毒性能被 MnTDM 阻止。这些调查结果也为 Parkinson 与氧化应力联系的疾病和另外的混乱建议了一条新奇治疗学的途径。 | Ping Chen Ang Li Mengjie Zhang Meilan He Zhen Chen Xiaokang Wu Chunjun Zhao Shilong Wang Liping Liang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，2： | 4 |
| 2 | Salvia miltiorrhiza-asarum ointment combined with Chinese medical massage alleviates symptoms of osteoarthritis in a rat model through the Notch1/matrix metalloproteinase-13 signaling pathway显示文摘OBJECTIVE:This study investigated the effect of salvia miltiorrhiza-asarum ointment(SMAO)plus Chinese medical massage on knee osteoarthritis in a rat model.METHODS:Hulth's method was used to establish a Sprague-Dawley rat model of knee osteoarthritis(OA).The levels of matrix metalloproteinase-13(MMP-13),collagen-Ⅱ,aggrecan,interleukin(IL)-1β,tumor necrosis factor-α(TNF-α),and IL-6 were measured by enzyme-linked immunosorbent assays.The joint space was assessed by a Perlove X-ray system.Histopathology was examined by hematoxylin-eosin and Safranin O staining.The mRNA and protein expression levels of Notch1,MMP-13,collagen-Ⅱ,and aggrecan were measured by quantitative reverse transcription-polymerase chain reaction and Western blotting,respectively.RESULTS:SMAO plus Chinese medical massage significantly decreased the levels of MMP-13,IL-1β,TNF-α,and IL-6,and increased serum collagen-Ⅱ and aggrecan levels.Pathological injury of the knee joint was improved by SMAO treatment.mRNA and protein expression of Notch1 and MMP-13 was remarkably downregulated,but collagen-Ⅱ and aggrecan levels were significantly upregulated in cartilage tissues.CONCLUSION:SMAO combined with Chinese medical massage effectively relieves OA symptoms,which may involve inhibiting inflammation through the Notch1/MMP-13 signaling pathway. | LAI Qingzhong ZHANG Xianjie CHEN Meilan HAN Zhicun | 2021 | Journal of Traditional Chinese Medicine2021，41，4： | 3 |
| 3 | Complete Genome Sequences of Two Chinese Virulent Avian Coronavirus Infectious Bronchitis Virus Variants显示文摘 | Meilan Mo Baicheng Huang Ping Wei Tianchao Wei Qiuying Chen Xiuying Wang Meng Li Wensheng Fan | 2012 | Journal of Virology2012，，19： | 2 |
| 4 | Intravenous umbilical cord mesenchymal stem cell infusion for the treatment of combined malnutrition nonunion of the humerus and radial nerve injury显示文摘 | Guofang Xue Meilan He Jie Zhao Yan Chen Yun Tian Baozhen Zhao Bo Niu | 2011 | Regenerative medicine2011，6，6： | 1 |
| 5 | Ionic liquids extraction of Para Red and Sudan dyes from chilli power, chilli oil and food additive combined with high performance liquid chromatography显示文摘 | FAN Yunchang CHEN Meilan SHEN Tuchao | 2009 | Journal of Analytica Chimica Acta2009，650，1： | 1 |
| 6 | Ionic liquids extraction of Para Red and Sudan dyes from chilli power, chilli oil and food additive combined with high performance liquid chromatography 显示文摘 | FAN Yunchang CHEN Meilan SHEN Tuchau | 2009 | Journal of Analytica Chimica Acta2009，650，1： | 1 |
| 7 | 显示文摘 | FAN Yunchang HU Zhengliang CHEN Meilan | 2008 | Chin Chem Lett2008，19，8： | 1 |
| 8 | A novel voltammetric sensor for ascorbic acid based on molecularly imprinted poly( o -phenylenediamine- co - o -aminophenol)显示文摘 | Yong Kong Xueling Shan Jianfeng Ma Meilan Chen Zhidong Chen | 2013 | Analytica Chimica Acta2013，，： | 1 |
| 9 | Separation and determination of carbohydrates in drinks by ion chromatography with a sel f-regenerating suppressor and an evaporative light-scattering detector显示文摘 | JING LI MEILAN CHEN YAN ZHU | 2007 | Journal of Chromatography A2007，，1155： | 1 |
| 10 | The organization and function of the Golgi apparatus in dendrite development and neurological disorders显示文摘Dendrites are specialized neuronal compartments that sense, integrate and transfer information in the neural network. Their development is tightly controlled and abnormal dendrite morphogenesis is strongly linked to neurological disorders. While dendritic morphology ranges from relatively simple to extremely complex for a specified neuron, either requires a functional secretory pathway to continually replenish proteins and lipids to meet dendritic growth demands. The Golgi apparatus occupies the center of the secretory pathway and is regulating posttranslational modifications, sorting, transport, and signal transduction, as well as acting as a non-centrosomal microtubule organization center. The neuronal Golgi apparatus shares common features with Golgi in other eukaryotic cell types but also forms distinct structures known as Golgi outposts that specifically localize in dendrites. However, the organization and function of Golgi in dendrite development and its impact on neurological disorders is just emerging and so far lacks a systematic summary. We describe the organization of the Golgi apparatus in neurons, review the current understanding of Golgi function in dendritic morphogenesis, and discuss the current challenges and future directions. | Meilan Chen Lu Xu Yi Wu Peter Soba Chun Hu | 2023 | Genes & Diseases2023，10，6： | 0 |
| 11 | Flower development and sexual dimorphism in Vernicia montana显示文摘The mu oil tree(Vernicia montana Lour.) is a dioecious species, but the genetic mechanisms underlying its phenotypic sexual dimorphism are unclear. In this study, we determined two pivotal phases of sex differentiation of mu oil tree via morphological and histological analyses of unisexual flowers:(Ⅰ) differentiation of male or female primordia to produce staminate flowers(SFs) or transient hermaphrodite flowers(HFs),and(Ⅱ) complete abortion of stamens in transient HFs to generate pistillate flowers(PFs). A total of 1621 sex-biased genes were identified by comparative transcriptome analysis which exhibited elevated rates of protein evolution than unbiased genes. The female-biased genes were enriched in the production of defense compounds while male-biased genes were focused on the production of viable pollens. Transcriptomebased analysis revealed that the differentially expressed genes(DEGs) between PFs and SFs in phase Ⅰ involved in abscisic acid(ABA), auxin(AUX), cytokinin(CK), ethylene(ET), and gibberellin(GA) biosynthesis and signaling showed higher expression levels in males than in females in general, whereas the DEGs involved in jasmonic acid(JA) and salicylic acid(SA) pathways displayed opposite expression patterns. Moreover,differentially expressed endogenous ABA, AUX, GAs, JA, and SA exhibited consistent biased expression patterns with the DEGs by UPLC-MSbased analysis. Exogenous application of an anti-ethylene plant growth regulator could promote the development of stamens in PFs and generated HFs. Comparative transcriptomic and hormonal analyses of PFs and SFs in phase Ⅱ indicated an increase in ET concentration when abortion of stamens in PFs occurred. This study suggested that phytohormones play key roles in sex dimorphism and ET may determine the development of stamens in PFs of mu oil tree, which provides an insight into plant sex differentiation mechanisms. | Wenying Li Jingzhen Chen Xiang Dong Meilan Liu Guibin Wang Lin Zhang | 2024 | Horticultural Plant Journal2024，10，2： | 0 |
| 12 | Decoration of carbon encapsulated nitrogen-rich MoxN with few-layered MoSe2 nanosheets for high-performance sodium-ion storage显示文摘Transition metal nitrides have become the focus of research in sodium ion batteries(SIBs)due to their unique metal properties and high theoretical capacity.However,the low actual capacity is still the main bottleneck for their application.Herein,using Mo-aniline frameworks as precursors,the carbon encapsulated nitrogen-rich Mo_(x)N is decorated by few-layered MoSe_(2) nanosheets(MoSe_(2)@Mo_(x)N/C-I)after the facile calcinating,selenizing,and nitriding.The carbon encapsulation can effectively strengthen the structural stability of Mo_(x)N.The nitrogen-rich Mo_(x)N and decoration of few-layered MoSe_(2) can create rich heterointerfaces and extra active sites for rapid sodium-ion storage,thus promoting reaction kinetics and improving actual capacity.The MoSe_(2)@Mo_(x)N/C-I as an anode achieves a large reversible capacity of 522.8 mAh g^(-1)at 0.1 A g^(-1),and 254.3 mAh g^(-1)capacity is obtained after 6000 cycles at 5.0 A g^(-1),showing signally improved sodium-ion storage properties.The storage mechanisms and kinetic behaviors are described systematically via the advanced testing techniques and density functional theory(DFT)calculations.It is found that the nitrogen-rich Mo_(x)N as the substrate is the basis of long cycling stability,and the few-layered MoSe_(2) are the key to improving actual capacity.This work indicates that the decoration of few-layered selenides has a broad application prospect in high-performance metal-ion batteries. | Tao Lu Baoquan Liu Fanyan Zeng Guo Cheng Shile Chu Meilan Xie Zhi Chen Zhaohui Hou | 2022 | Journal of Energy Chemistry2022，31，11： | 0 |
| 13 | Study on Frost Prevention and Drought Resistance Effect of Potato under Different Planting Methods显示文摘According to different planting test data,meteorological data,field planting survey and expert interview data in recent years,frost prevention and drought resistance effect of potato under different planting methods were studied using agro-meteorological disaster risk index analysis method. The results showed that the risk index of potato with the full-film planting was small due to good thermal insulation and soil moisture conservation performance. The risk index of potato with half-film planting( flat mulching,ridging planting and furrow planting) was moderate,while that of ridge tillage without mulching,double rows,full of stars and flat planting was large,and their frost prevention and drought resistance effect were poor. It provides support and reference for understanding the frost and drought conditions of potatoes under different planting methods and carrying out insurance weather services for farmers and production managers. | Sun Jun Chen Yongxu Guo Junwei Li Shuxia Yang Meilan | 2019 | Meteorological and Environmental Research2019，10，1： | 0 |
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