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| 1 | Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer显示文摘Vγ9Vδ2 T cells are promising candidates for cellular tumor immunotherapy.Due to their HLA-independent mode of action,allogeneic Vγ9Vδ2 T cells can be considered for clinical application.To apply allogeneic Vγ9Vδ2 T cells in adoptive immunotherapy,the methodology used to obtain adequate cell numbers with optimal effector function in vitro needs to be optimized,and clinical safety and efficacy also need to be proven.Therefore,we developed a novel formula to improve the expansion of peripheralγδT cells from healthy donors.Then,we used a humanized mouse model to validate the therapeutic efficacy of expandedγδT cells in vivo;furthermore,the expandedγδT cells were adoptively transferred into late-stage liver and lung cancer patients.We found that the expanded cells possessed significantly improved immune effector functions,including proliferation,differentiation,and cancer cell killing,both in vitro and in the humanized mouse model.Furthermore,a phase I clinical trial in 132 late-stage cancer patients with a total of 414 cell infusions unequivocally validated the clinical safety of allogeneic Vγ9Vδ2 T cells.Among these 132 patients,8 liver cancer patients and 10 lung cancer patients who received≥5 cell infusions showed greatly prolonged survival,which preliminarily verified the efficacy of allogeneic Vγ9Vδ2 T-cell therapy.Our clinical studies underscore the safety and efficacy of allogeneic Vγ9Vδ2 T-cell immunotherapy,which will inspire further clinical investigations and eventually benefit cancer patients. | Yan Xu Zheng Xiang Mohammed Alnaggar Léonce Kouakanou Jiawei Li Junyi He Jiashuang Yang Yi Hu Yan Chen Li Lin Jianlei Hao Jingxia Li Jibing Chen Man Li Qingling Wu Christian Peters Qinghua Zhou Jianshuang Li Yingqing Liang Xiaohua Wang Baohui Han Meili Ma Dieter Kabelitz Kecheng Xu Wenwei Tu Yangzhe Wu Zhinan Yin | 2021 | Cellular & Molecular Immunology2021，18，2： | 8 |
| 2 | 500 years of mercury production: global annual inventory by region until 2000 and associated emissions 显示文摘 | Hylander L D Meili M | 2003 | Sci Total Environ2003，304，13： | 1 |
| 3 | Removal of tannery dye from aqueous solution using papaya seed as an efficient natural biosorbent显示文摘 | WEBER C T FOLETTO E L MEILI L | 2013 | Water Air Soil Pollut2013，224，2： | 1 |
| 4 | 500 years of mercury production: globalannual inventory by region until 2000 and associated emis- sions 显示文摘 | Hylander L Meili M | 2003 | Science of the Total Environment2003，304，： | 1 |
| 5 | An Efficent and Scalable Density-based Clustering Algorithm显示文摘 | LüYinghua Ma Tinghuai Tang Meili | 2015 | Neurocomputing2015，171，1： | 1 |
| 6 | Mercury Net Methylation in Five Tropical Flood PlainRegions of Brazil:High in the Root Zone of Floating Macrophyte Mats but Low in Surface Sediments and Flooded Soils显示文摘 | Guimaraes J R D Meili M Hylander L D | 2000 | The Science of the Total Environment2000，261，： | 1 |
| 7 | 500 years of mercury production: global annual inventory by region until 2000 and associated e- missions显示文摘 | Hylander L D Meili M | 2003 | Science of the Total Environment2003，304，： | 1 |
| 8 | Fluid Dynamics of Fluidized and Vibrofluidized Beds Operating with Geldart C Particles 显示文摘 | Meili L Daleffe R Freire J | 2012 | Chemical Engineering and Technology2012，35，9： | 1 |
| 9 | Studying of micro-bonding in diffusion welding joint for composite显示文摘 | Liming L Meili Z Longxiu P | 2001 | Materials Science and Engineering2001，315，12： | 1 |
| 10 | Mercury net methylation in five tropical flood plain regions of Brazil: high in the root zone of floating macrophyte mats but low in sur- face sediments and flooded soil显示文摘 | Guimaraes J R D Meili M Hylander L D | 2000 | Sci Total Environ2000，29，61： | 1 |
| 11 | Partitioning of Hg between solid and dissolved organic matter in the humus layer of boreal forests 显示文摘 | J&erblom S Meili M Bringnnrk L Johansson K Kleja D Bergkvist B | 2008 | Water Air & Soil Pollution2008，189，1： | 1 |
| 12 | Mercury Net Methylation in Five Tropical Flood Plain Regions of Brazil:High in the Root Zone of Floating Macrophyte Mats But Low in Surface Sediments and Flooded Soils显示文摘 | Guimaraes J R D Meili M Hylander L D | 2000 | The Science of the Total Environment2000，2，61： | 1 |
| 13 | Barrier capacity of human placenta for nanosized materials显示文摘 | Wick P Malek A Martser P Meili D Maeder-Althaus X Diener L | 2010 | Environ Health Perspect2010，118，3： | 1 |
| 14 | 500 years of mercury production:global annual inventory by region until 2000 and associated emissions显示文摘 | Hylander L D Meili M | 2003 | Science of the Total Environment2003，304，1： | 1 |
| 15 | Mercury net methylation in five tropical flood plain regions of Brazil: high in the root zone of floating macrophyte mats but low in surface sediments and flooded soils 显示文摘 | Guimaraes J R Meili M Hylander L D | 2000 | Sci Total Environ2000，261，13： | 1 |
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