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| 1 | Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature显示文摘从 pluripotent 干细胞导出的 Cardiomyocytes 能在药测试,疾病建模和基于房间的治疗被使用。没有 procardiogenic 生长因素,然而,从 pluripotent 干细胞的 cardiomyogenesis 的效率通常是低的,产生 cardiomyocyte 人口是异构的。这里,我们证明导致的 pluripotent 干细胞( iPSCs )能从鼠科的室的 myocytes ( VM )被导出,并且与从各种各样的体的房间类型导出的 iPSCs 的另外的报告一致,自发地作为与遗传上匹配的胚胎的干细胞(转换字符)或 iPSCs 相比区分 cardiomyocytes 进跳动的显著地更高的倾向从尾巴尖端成纤维细胞导出的 导出VM 的 iPSCs ( ViPSCs )展览。惊人地,导出 ViPSC 的 cardiomyocytes 显示的多数室的显型。在 ViPSCs 的提高的室的 myogenesis 在区别的早阶段经由心血管的祖先的增加的数字被调停。以便从 ViPSCs 调查提高的室的 myogenesis 的机制,我们执行了全球基因表示和 DNA methylation 分析,它揭示了可以涉及在 pluripotent 干细胞指定 VM 命运的不同 epigenetic 签名。 | Huansheng Xu B Alexander Yi Hao Wu Christoph Bock Hongcang Gu Kathy O Lui Joo-Hye C Park Ying Shao Alyssa K Riley Ibrahim J Domian Erding Hu Robert Willette John Lepore Alexander Meissner Zhong Wang Kenneth R Chien | 2012 | Cell Research2012，22，1： | 7 |
| 2 | Isolation and charactefisation of a diverse family of Arabidopsis two and three-fingered C2H2 zinc finger protein genes and cDNAs显示文摘 | MEISSNER R MICHAEL A J | 1997 | Plant Mol Bio1997，33，4： | 1 |
| 3 | In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state显示文摘 | Wernig M Meissner A Foreman R | 2007 | Nature2007，448，7151： | 1 |
| 4 | Effects of 3 - week oral treatment with the antioxidant thioctic acid (alpha - lipoic acid) in symptomatic diabetic polyneuropathy 显示文摘 | Ruhnau K J Meissner H P Firm J R | 1999 | Diabet Med1999，16，12： | 1 |
| 5 | Effects of sheep exclusion on the soil seed bank and annual vegetation in chenopod shrub lands of South Australia显示文摘 | Meissner R A Facelli J M | 1999 | Journal of Arid Environment1999，42，2： | 1 |
| 6 | Effect of sheep exclusion on the soil seed bank and annual vegetation in chenopod shrub lands of South Australia 显示文摘 | Meissner R A Facelli J M | 1999 | Journal of Arid Environment1999，42，2： | 1 |
| 7 | Ein neuer Effekt bei Eintritt der Supraleitfhigkeit显示文摘 | Meissner W Ochsenfeld R | 1933 | Naturw1933，21，44： | 1 |
| 8 | Downregulation of TAP1in B lymphocytes by cellular and Epstein-Barr virus-encoded interleukin-10显示文摘 | ZEIDLER R EISSNER G MEISSNER P | 1997 | Blood1997，90，6： | 1 |
| 9 | Reprogramming efficiency following somatic cell nuclear transfer is influenced by the differentiation and methylation state of donor nucleus 显示文摘 | BLELLOCH R WANG Z MEISSNER A | 2006 | Stem Cells2006，24，9： | 1 |
| 10 | Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells显示文摘 | Meissner A Wernig M Jaeniscb R | 2007 | Nat Biotechnol2007，25，10： | 1 |
| 11 | Human papillomavirus prevalence in women with normal cytology and with cervical cancer in Natal显示文摘 | Fernandes J V Meissner R de V Carvalho M G | 2011 | Brazil Mol Med Rep2011，4，6： | 1 |
| 12 | Management effects on forms of phosphorus in soil and leaching losses 显示文摘 | Leinweber L Meissner R Eckhardt KU et tal | 1999 | European Journal of Soil Science1999，50，： | 1 |
| 13 | Catheter-directed thrombolysis for lower extremity deep venous thrombosis: report of a national muhicenter registry 显示文摘 | MEWISSEN M W SEABROOK G R MEISSNER M H | 1999 | Radiology1999，211，1： | 1 |
| 14 | In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state显示文摘 | Wernig M Meissner A Foreman R | 2007 | Nature2007，448，7151： | 1 |
| 15 | Effects of sheep exclusion on the soil seed bank and annual vegetation in chenopod shrublands of South Australia显示文摘 | Meissner R A Facelli J M | 1999 | Journal of Arid Environments1999，42，： | 1 |
| 16 | Reprogramming efficiency following somatic cell nuclear transfer is influenced by the differentiation and methylation state of the donor nucleus显示文摘 | Blelloch R Wang Z Meissner A Pollard S Smith A Jaenisch R | 2006 | Stem Cells2006，24，9： | 1 |
| 17 | Sensitivity of the Pacific white shrimp, Penaeus vannamei, to aflatoxin B1 显示文摘 | Ostrowski - Meissner H T LeaMaster B R Duerr E O | 1995 | Aquaculture1995，131，： | 1 |
| 18 | Hormone-balancing and pharmacological effects of therapeutic doses of Lepidium peruvianum (Maca-GO) in poslmenopausal women 显示文摘 | MEISSNER HO REICH -BILINSKA H MROZIKIEWICZ R | 2005 | Menopause2005，12，6： | 1 |
| 19 | In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state显示文摘 | Wernig M Meissner A Foreman R | 2007 | Nature2007，448，7151： | 1 |
| 20 | Cortisol levels predict motion sickness tolerance in women but not in men显示文摘 | Meissner K Enck P Muth E R | 2009 | Physiol Behav2009，97，1： | 1 |
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