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您的检索式：作者名="Meiting Shen"
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| 1 | Histone modification landscape and the key significance of H3K27me3 in myocardial ischaemia/reperfusion injury显示文摘Histone modifications play crucial roles in the pathogenesis of myocardial ischaemia/reperfusion(I/R)injury.However,a genome-wide map of histone modifications and the underlying epigenetic signatures in myocardial I/R injury have not been established.Here,we integrated transcriptome and epigenome of histone modifications to characterize epigenetic signatures after I/R injury.Disease-specific histone mark alterations were mainly found in H3K27me3-,H3K27ac-,and H3K4me1-marked regions 24 and 48 h after I/R.Genes differentially modified by H3K27ac,H3K4me1 and H3K27me3 were involved in immune response,heart conduction or contraction,cytoskeleton,and angiogenesis.H3K27me3 and its methyltransferase polycomb repressor complex 2(PRC2)were upregulated in myocardial tissues after I/R.Upon selective inhibition of EZH2(the catalytic core of PRC2),the mice manifest improved cardiac function,enhanced angiogenesis,and reduced fibrosis.Further investigations confirmed that EZH2 inhibition regulated H3K27me3 modification of multiple pro-angiogenic genes and ultimately enhanced angiogenic properties in vivo and in vitro.This study delineates a landscape of histone modifications in myocardial I/R injury,and identifies H3K27me3 as a key epigenetic modifier in I/R process.The inhibition of H3K27me3 and its methyltransferase might be a potential strategy for myocardial I/R injury intervention. | Le Ni Bowen Lin Yanping Zhang Lingjie Hu Jianghua Lin Fengmei Fu Meiting Shen Can Li Lei Chen Jian Yang Dan Shi Yi-Han Chen | 2023 | Science China(Life Sciences)2023，66，6： | 0 |
| 2 | Development and application of high-precision multifunction astronomical plate digitizers in China显示文摘Before charge-coupled device detectors became widely employed in observational astronomy,for more than a hundred years,the main detection method was photography on astronomical glass plates.Recently,in order to preserve these historical data and maintain their usability,the International Astronomical Union has appealed to all countries for global digitization of astronomical plates by developing or adopting advanced digitization technology.Specialized digitizers with high precision and high measuring speed represent key equipment for this task.The Shanghai Astronomical Observatory and the Nishimura Co.,Ltd in Japan cooperated between 2013 and 2016 to develop the first Chinese high-precision astronomical plate digitizer,which was then used for complete digitization of all nighttime-observation astronomical plates in China.Then,in 2019–2021,the Shanghai Astronomical Observatory independently developed new models of plate digitizers that enabled countries such as Uzbekistan and Italy to digitize their astronomical plates.Additionally,a new high-precision and multifunction digitizer was also used to digitize valuable microscope slides from the Shanghai Natural History Museum,providing a successful example of cross-domain application of high-precision digitization technology. | Meiting Yang Yong Yu Liangliang Wang Zhengjun Shang Changshun Liu Lixin Zheng Zhendong Chen Jing Yang Dongmei Da Shan Dong Shiyin Shen Zhenghong Tang Jianhai Zhao | 2024 | Astronomical Techniques and Instruments2024，1，1： | 0 |
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