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您的检索式：作者名="Meixin Chen"
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| 1 | TRIM14通过抑制p62介导的cGAS的选择性自噬降解促进固有免疫反应显示文摘环GMP-AMP合成酶(cGAS)是细胞内识别DNA病毒,激活免疫反应的重要受体,但是对于它翻译后修饰的调控分子机制还不甚了解。 | Meixin Chen Qingcai Meng Yunfei Qin Puping Liang Peng Tan Lian He Yubin Zhou Yongjun Chen 黄军就 Rong-Fu Wang 崔隽 | 2017 | 科学新闻2017，19，4： | 0 |
| 2 | Elemental sulfur upregulated testicular testosterone biosynthesis by associating with altered gut microbiota in mice显示文摘Elemental sulfur has been used as a traditional Chinese medicine to treat the late-onset hypogonadism and impotence without a clarified mechanism for many hundreds of years.In the present study,mice were received sulfur or distilled water for 35 days by daily intragastric gavage at a dose of 250 mg/kg body weight.Then,the serum testosterone level and genes associated with testicular testosterone biosynthesis(TTB)were detected.The gut microbiota was also analyzed by 16S rRNA gene sequencing.Serum testosterone level was significantly increased by 291.1%in sulfur-treated mice.The H2S levels in serum and feces were significantly increased.The expression of genes associated with TTB including StAR,p450c17,3β-HSD,and P450scc in testes were significantly upregulated by Sulfur and NaHS,suggesting that sulfur promotes TTB depending on H2S.In addition,sulfur increased the diversity of gut microbiota and the abundance of several bacteria associated with sulfur metabolism,including genus Prevotella,which might be positively associated with serum level of testosterone in boys.Five pathways including bile secretion,carotenoid biosynthesis,lipid biosynthesis proteins,propanoate metabolism,and biosynthesis of type II polyketide products,were identified to associate with sulfur.Together,our results suggested that sulfur upregulated testicular testosterone biosynthesis via H2S,which was associated with alteration of gut microbiota in mice.Our study highlights a mechanism for the treatment of late-onset hypogonadism and impotence by sulfur. | YUAN BI TIANQI LI HONGJIE PAN MING GUO LIANGKANG CHEN QI QI MEIXIN ZHANG LINGLING ZHANG LININ YU XIAOFENG WAN HUAJUN ZHENG RUNSHENG LI | 2020 | BIOCELL2020，44，3： | 0 |
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