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| 1 | Cloning and functional characterization of Rht8,a“Green Revolution”replacement gene in wheat显示文摘Dear Editor,Wheat(Triticum aestivum)is a major staple crop in the world and provides~20%of the food calories for human consumption(Appels et al.,2018).During the 1960s and 1970s,the introduction of two semi-dwarfing genes Rht-B1b and Rht-D1b in wheat varieties strikingly improved lodging resistance and harvest index,and therefore substantially increased grain yield,resulting in the well-known'Green Revolution'(Peng et al.,1999).However,plants carrying Rht-B1b and Rht-D1b suffer from several drawbacks. | Hongchun Xiong Chunyun Zhou Meiyu Fu Huijun Guo Yongdun Xie Linshu Zhao Jiayu Gu Shirong Zhao Yuping Ding Yuting Li Jiazi Zhang Ke Wang Xuejun Li Luxiang Liu | 2022 | Molecular Plant2022，15，3： | 7 |
| 2 | GmPIN1-mediated auxin asymmetry regulates leaf petiole angle and plant architecture in soybean显示文摘Crop breeding during the Green Revolution resulted in high yields largely due to the creation of plants with semi-dwarf architectures that could tolerate high-density planting.Although semi-dwarf varieties have been developed in rice,wheat and maize,none was reported in soybean(Glycine max),and few genes controlling plant architecture have been characterized in soybean.Here,we demonstrate that the auxin efflux transporter PINFORMED1(GmPIN1),which determines polar auxin transport,regulates the leaf petiole angle in soybean.CRISPR-Cas9-induced Gmpin1abc and Gmpin1bc multiple mutants displayed a compact architecture with a smaller petiole angle than wildtype plants.GmPIN1 transcripts and auxin were distributed asymmetrically in the petiole base,with high levels of GmPIN1a/c transcript and auxin in the lower cells,which resulted in asymmetric cell expansion.By contrast,the(iso)flavonoid content was greater in the upper petiole cells than in the lower cells.Our results suggest that(iso)flavonoids inhibit GmPIN1a/c expression to regulate the petiole angle.Overall,our study demonstrates that a signal cascade that integrates(iso)flavonoid biosynthesis,GmPIN1a/c expression,auxin accumulation,and cell expansion in an asymmetric manner creates a desirable petiole curvature in soybean.This study provides a genetic resource for improving soybean plant architecture. | Zhongqin Zhang Le Gao Meiyu Ke Zhen Gao Tianli Tu Laimei Huang Jiaomei Chen Yuefeng Guan Xi Huang Xu Chen | 2022 | Journal of Integrative Plant Biology2022，64，7： | 1 |
| 3 | Antibody-dependent cellular cytotoxicity response to SARS-CoV-2 in COVID-19 patients显示文摘Antibody-dependent cellular cytotoxicity(ADCC)responses to viral infection are a form of antibody regulated immune responses mediated through the Fc fragment.Whether severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)triggered ADCC responses contributes to COVID-19 disease development is currently not well understood.To understand the potential correlation between ADCC responses and COVID-19 disease development,we analyzed the ADCC activity and neutralizing antibody response in 255 individuals ranging from asymptomatic to fatal infections over 1 year post disease.ADCC was elicited by 10 days post-infection,peaked by 11-20 days,and remained detectable until 400 days post-infection.In general,patients with severe disease had higher ADCC activities.Notably,patients who had severe disease and recovered had higher ADCC activities than patients who had severe disease and deceased.Importantly,ADCC activities were mediated by a diversity of epitopes in SARS-COV-2-infected mice and induced to comparable levels against SARS-CoV-2 variants of concern(VOCs)(B.1.1.7,B.1.351,and P.1)as that against the D614G mutant in human patients and vaccinated mice.Our study indicates anti-SARS-CoV-2 ADCC as a major trait of COVID-19 patients with various conditions,which can be applied to estimate the extra-neutralization level against COVID-19,especially lethal COVID-19. | Yuanling Yu Meiyu Wang Xiaoai Zhang Shufen Li Qingbin Lu Haolong Zeng Hongyan Hou Hao Li Mengyi Zhang Fei Jiang Jiajing Wu Ruxia Ding Zehua Zhou Min Liu Weixue Si Tao Zhu Hangwen Li Jie Ma Yuanyuan Gu Guangbiao She Xiaokun Li Yulan Zhang Ke Peng Weijin Huang Wei Liu Youchun Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 0 |
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