|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Clinicopathological predictors of long-term benefit in breast cancer treated with neoadjuvant chemotherapy显示文摘AIM To investigate the survival impact of clinicopathological factors, including pathological complete response(p CR) and tumor-infiltrating lymphocytes(s TIL) levels according to subtypes, in breast cancer(BC) patients who received neo-adjuvant chemotherapy(NAC).METHODS We evaluated 435 BC patients who presented and received NAC at the Instituto Nacional de Enfermedades Neoplasicas from 2003 to 2014. s TIL was analyzed as the proportion of tumor stroma occupied by lymphocytes, and was prospectively evaluated on hematoxylin and eosin-stained sections of the preN AC core biopsy. p CR was considered in the absence of infiltrating cancer cells in primary tumor and axillary lymph nodes. Analysis of statistical association between clinical pathological features, s TIL, p CR and survival were carried out using SPSSvs19.RESULTS Median age was 49 years(range 24-84 years) and the most frequent clinical stage was ⅢB(58.3%). Luminal A, Luminal B, HER2-enriched and(triple-negative) TN phenotype was found in 24.6%, 37.9%, 17.7% and 19.8%, respectively. p CR was observed in 11% and median percentage of s TIL was 40%(2%-95%) in the whole population. p CR was associated to Ct1-2(P = 0.045) and to high s TIL(P = 0.029) in the whole population. There was a slight trend towards significance for s TIL(P = 0.054) in Luminal A. s TIL was associated with grade Ⅲ(P < 0.001), no-Luminal A subtype(P < 0.001), RE-negative(P < 0.001), PgR-negative(P < 0.001), HER2-positive(P = 0.002) and p CR(P = 0.029) in the whole population. Longer disease-free survival was associated with grade Ⅰ-Ⅱ(P = 0.006), cN 0(P < 0.001), clinical stage Ⅱ(P = 0.004), ER-positive(P < 0.001), Pg R-positive(P < 0.001), luminal A(P < 0.001) and p CR(P = 0.002). Longer disease-free survival was associated with grade Ⅰ-Ⅱ in Luminal A(P < 0.001), N0-1 in Luminal A(P = 0.045) and TNBC(P = 0.01), clinical stage Ⅱ in Luminal A(P = 0.003) and TNBC(P = 0.038), and pC R in TNBC(P < 0.001). Longer overall survival was associated with grade Ⅰ-Ⅱ(P < 0.001), ER-positive(P < 0.001), PgR-positive(P < 0.001), Luminal A(P < 0.001), cN 0(P = 0.002) and p CR(P = 0.002) in the whole population. Overall survival was associated with clinical stage Ⅱ(P = 0.017) in Luminal A, older age(P = 0.042) in Luminal B, and pC R in TNBC(P = 0.005).CONCLUSION Predictive and prognostic values of clinicopathological features, like p CR and s TIL, differ depending on the evaluated molecular subtype. | Marco Galvez Carlos A Castaneda Joselyn Sanchez Miluska Castillo Lia Pamela Rebaza Gabriela Calderon Miguel De La Cruz Jose Manuel Cotrina Julio Abugattas Jorge Dunstan Henry Guerra Omar Mejia Henry L Gomez | 2018 | World Journal of Clinical Oncology2018，9，2： | 4 |
| 2 | Differential expression of the fractalkine chemokine receptor (CX3CR 1) in human rnonocytes during differentiation显示文摘传播单核白血球(瞬间) 可以连续地使人重新住入巨噬细胞(MAC ) 或树枝状的房间(DC ) 维持动态平衡的人口。MAC 和 DC 是玩不同、互补的免疫学的功能的专业化房间。因此,他们现在的不同迁移的性质。明确地,而 MAC 大部分留在纸巾, DC 能够从外部纸巾移居到淋巴的机关。这个工作的目的是分析 fractalkine 受体的表达式(CX 3 CR1 ) 在 monocytic 区别进程期间。两 CX 3 CR1 mRNA 和蛋白质。在瞬间区别过程期间, CX 3 CR1 是在 DC 和 MAC 的 downregulated。然而, MAC 显示出显著地更高的 CX 3 CR1 表示层次比 DC。我们也观察了对抗 CX 3 由干扰素(IFN ) 的 CR1 规定 -γ并且 interleukin (IL )-4 在通过古典、其他的 MAC 小径的 MAC 激活期间分别地。IFN-γ禁止了 CX 3 CR1,而是 IL-4 导致了它。另外,我们表明了在 CX 3 由可溶的 fractalkine 的 CR1 表示和 apoptosis 预防(sCX 3 CL1 ) 在瞬间, DC 和 MAC。这是表明顺序、微分的 CX 3 CR1 调整在瞬间区别期间。最重要地,我们表明了在 CX 3 CR1 表示和房间幸存面对 sCX 3 CL1。 | Cecilia Analia Panek Maria Victoria Ramos Maria Pilar Mejias Maria Iimena Abrey-Recalde Romina Iimena Fernandez-Brando Maria Soledad Gori Gabriela Veronica Salamone2 Marina Sandra Palermo | 2015 | Cellular & Molecular Immunology2015，12，6： | 3 |
| 3 | 城乡居民食材消耗的多尺度地域差异及政策启示——基于烟台、兰州、新乡、九江家庭食谱的实证分析显示文摘近年中国粮食国际依赖程度持续上升,降低损耗、避免浪费成为解决粮食安全体系韧性问题的重要途径。然而由于不同地域城乡居民的饮食结构明显不同,实施开源节流的食品供应保障政策法规必须重视居民食材消耗的地域差异性,因此基于全球化视角解析居民食材的本地供应比例及其地域差异成为有待补阙的课题。为此,以烟台、兰州、新乡、九江4个城市为例,采用问卷调查的方式,探究4个城市食材消耗和对应生产土地需求量的差异性。结果显示:(1)不同食材与对应消耗的土地资源存在显著的地域差异,且这一差异与城市自然本底和居民饮食习俗密切关联;(2)4个城市居民食谱的全球化、本土化和本地化具有明显区别,虽然不同食材的本地化程度差异相对较小,但全球化程度差异显著。基于分析结果,探讨了粮食安全与反食品浪费的政策建议:一是反食品浪费的政策法规实施,需充分结合居民食材消耗的地域性特征,建立针对性的食材消耗标准与动态监测系统;二是在全球波动、强调粮食安全的背景下,地方政府应结合国土空间规划,讨论城市预留本地食材供应的战略性产地的可能性,以减少运输过程中的损耗。 | 赵渺希 师浩辰 李昕 Alfonso Mejia 姚玥希 王嘉钰 毕宇萱 | 2022 | 自然资源学报2022，37，10： | 2 |
| 4 | Management of Enteroatmospheric Fistulae in the Open Abdomen显示文摘 | Ramsay Philip T Mejia Vicente A | 2010 | The American Surgeon2010，，6： | 2 |
| 5 | Evaluation of Operational National Weather Service Gridded Flash Flood Guidance over the A rkansas R ed R iver B asin显示文摘 | Dugwon Seo Tarendra Lakhankar Juan Mejia Brian Cosgrove Reza Khanbilvardi | 2013 | J Am Water Resour Assoc2013，，6： | 2 |
| 6 | Physiological basis for effect of physical conditioning on chronic ethanol-induced hypertension in a rat model显示文摘 | Kazim Husain Jose Mejia Jainarine Lalla | 2006 | Molecular and Cellular Biochemistry (-)2006，，1： | 2 |
| 7 | Changing patterns of access site complications with the use of pereutaneous closure devices显示文摘 | Toursarkissian B Mejia A Smilanich RP | 2001 | Vascular Surgery2001，35，： | 1 |
| 8 | Application of platelet-rich plasma to enhance tissue repair显示文摘 | Wroblewski AP Mejia HA Wright VJ | 2010 | Oper Tech Orthop2010，20，2： | 1 |
| 9 | Estimation of capillary pressure and relative permeability functioris centrifuge experiments显示文摘 | Nordtvedt J E Mejia G Yang P | 1993 | SPE Res Eng1993，8，： | 1 |
| 10 | Notes-hybrid: splenectomy (transvaginal/umbilieal) 显示文摘 | ALMAU TRENARD H MEJIAS GONZALEZ J ARELLANO CORAGGIO J | 2011 | Aeta Gastroenterol Latinoam2011，41，3： | 1 |
| 11 | Quantification of Human IgE Immunoreact ive Soybean Proteins in CommercialSoy Ingredients and Products显示文摘 | Song YS Martinez-Villaluenga C De Mejia EG | | 0，，06： | 1 |
| 12 | A new frontier in soy bioactive peptides that may prevent age-related chronic diseases显示文摘 | WANG Wenyi GONZALEZ de MEJIA E | 2005 | Comprehensive Reviews in Food Science and Food Safety2005，4，4： | 1 |
| 13 | Hot ductility behavior of a low carbon advanced high strength steel (AHSS) microalloyed with boron显示文摘 | MEJIA I BEDOLLA-JACUINDE A MALDONADO C | 2011 | Materials Science and Engineering A2011，528，1314： | 1 |
| 14 | Trends in size classified particle number concentration in subtropical Brisbane, Australia, based on a 5 year study 显示文摘 | Mejia J F Wraith D Mengersen K | 2006 | Atmospheric Environment2006，40，： | 1 |
| 15 | Experiences in developing collaborative engineering environments: an action research approach 显示文摘 | MEJIA R LOPES A MOLINA A | 2007 | Computer in Industrial2007，58，4： | 1 |
| 16 | Experimental hemolysis model to study bilirubin encephalopathy in rat brain显示文摘 | Gerardo Barragtm Mejia | 2008 | Journal of Neuroscience Methods2008，168，： | 1 |
| 17 | Intravenous palivizumab and ribavirin combination for respiratory syncytial virus disease in high-risk pediatric patients显示文摘 | Chavez--Bueno S Mejias A Merryman RA | 2007 | Pediatr Infect Dis J2007，26，12： | 1 |
| 18 | Effects of lead-arsenic combined exposure on central monoaminergic systerns显示文摘 | Mejia J Diaz Barriga F Calderon J Rios C Jimenez C M | 1997 | Neurotoxicology and Teratology1997，19，6： | 1 |
| 19 | Matching Compensation and Organization Strategies 显示文摘 | David B Balkin Gomez Mejia | 1990 | Strategic Management Journal1990，，11： | 1 |
| 20 | Use of in situ saturation data in estimation of two-phase flow functions in porous media显示文摘 | Mejia G M Mohanty K K Watson AT | 1995 | J Petroleum Science and Engineering1995，12，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员