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| 1 | 麦角硫因或可降低心血管疾病发生及死亡风险显示文摘目的近期研究发现一种健康饮食模式(HCFP)与降低心脏代谢疾病风险相关,但导致这种相关性的分子机制尚不明确。该研究旨在发现与这种饮食模式相关的血浆代谢物,并研究其与心脏代谢疾病发生和死亡风险的相关性。方法从全人群马尔默饮食和癌症研究中,筛选出3236名无心血管疾病和糖尿病史的参与者。运用液相色谱-质谱法对他们的112种血浆代谢物进行检测。通过多元线性回归和Bonfcrroni校正分析,发现其中与该饮食模式相关的代谢物。使用多变量Cox比例风险模型进行长期随访分析后,发现这些健康饮食的生物标志物与心脏代谢疾病的发生和死亡风险相关。结果平均随访21.4年期间,603人患心血管疾病,362人患糖尿病,843人死亡。基线资料中,5种健康饮食标志物与该饮食模式相关(P<0.0004),其中4种与至少一项研究终点相关(P<0.05)。麦角硫因是与该饮食模式相关性最强的代谢物,并且与降低冠心病风险(危害比0.85,P=0.01)、心血管死亡风险(危害比0.79,P=0.002)、全因死亡风险(麦角硫因每增加一个标准差的危害比,危害比0.86,P=4e-5)相关。结论我们发现高麦角硫因含量是降低心脏代谢疾病发生和死亡风险的独立标志物。而这种高含量很可能是由某种特殊的饮食方式造成的。 | Einar Smith Filip Ottosson Sophie Hellstrand Ulrika Ericson Marju Orho-Melander Celine Fernandez Olle Melander 冯博(译) | 2020 | 英国医学杂志中文版2020，23，4： | 4 |
| 2 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 3 | Microsurgical reconstruction:The weightbearing surface of the foot显示文摘 | Meland N B | 1990 | Microsurgery1990，11，1： | 1 |
| 4 | Increased risk of acute myocardial infarction and elevated levels of C-reactive protein in carriers of t he Thr-87 variant of the ATP receptor P2Y11 显示文摘 | Amisten S Melander O Wihlborg AK | 2007 | Eur Heart J2007，28，1： | 1 |
| 5 | The evaluation of large strains from industrial sheet metal stampings with a square grid 显示文摘 | Schedin E Melander A | 1986 | J Applied Metal Working1986，4，14： | 1 |
| 6 | Influence of food intake on presystemic clearance of drugs显示文摘 | Melander A McLean A | 1983 | Clin Pharmcokinet1983，8，4： | 1 |
| 7 | A 295i MAS NMR study of the pozzolanic activity of condensed silica fume and the hydration of Di and tricalcium silicate显示文摘 | JUSTNES H MELAND I BJORGUM J O | 1990 | Adv Cem Res1990，3，： | 1 |
| 8 | Enhanced oil recovery(EOR)by combining surfactant with low salinity injection显示文摘 | Annette Meland Johannessen Kristine Spildo | 2013 | Energy Fuels2013，27，： | 1 |
| 9 | Polymorphism in the β1-adrenergic receptor gene and hypertension显示文摘 | BENGTSSON K MELANDER O MARJU O M | 2001 | Circulation2001，104，： | 1 |
| 10 | Six new loci associated with blood low-density lipoprotein cholesterol,high-density lipoprotein cholesterol or triglyeerides in humans 显示文摘 | Kathiresan S Melander O Guidueci C | 2008 | Nat Genet2008，40，2： | 1 |
| 11 | Elevated plasma levels of N1-proBNP in patients with type 2 diabetes without overt cardiovascular disease显示文摘 | Melander O Israelsson B | 2004 | Diabetes Care2004，27，8： | 1 |
| 12 | Effect of ambient water temperature on sex de-terminism in the bule tilapia显示文摘 | DESPREZ D MELAND C | 1998 | Oreochromis Aureus Aquaculture1998，162，1： | 1 |
| 13 | Polymorphism in the beta(1 )-adrenergic receptor gene and hypertension显示文摘 | Bengtsson K Melander O Orho-Melander M | 2001 | Circulation2001，104，2： | 1 |
| 14 | An algorithm for maxillectomy defect reconstruction显示文摘 | Davison SP Sherris DA Meland NB | 1998 | Laryngoscope1998，108，2： | 1 |
| 15 | Rituximab in severe lupus nephritis: early B-cell depletion affects long-term renal outeome显示文摘 | Melander C Sallee M Trolliet P | 2009 | Clin J Am Soc Nephrol2009，4，3： | 1 |
| 16 | Six new loci associated with blood low-density lipoprotein cholestero, high-density lipoprotein cholesterol or triglyeerides in humans显示文摘 | Kathiresan S Melander O Guiducci C | 2008 | Nat Genet2008，40，1： | 1 |
| 17 | Comparison of dose standard units for drug utilization studies显示文摘 | Merlo J Wessling A Melander A | 1996 | Eur J Clin pharmacol1996，50，12： | 1 |
| 18 | Leukocyte count and incidence of hospitalizations due to heart failure 显示文摘 | EngstrSm G Melander O Hedblad B | 2009 | Circ Heart Fail2009，2，3： | 1 |
| 19 | Hypertension,cardiovascular risk and polymorphisms in genes controlling the cytochrome P450 pathway of arachidonic acid:A sex-specific relation?显示文摘 | Fava C Ricci M Melander O | 2012 | Prostaglandins Other Lipid Mediat2012，98，34： | 1 |
| 20 | Retinopathy in sub-jects with impaired fasting glucose : the NANSY Eye baseline report 显示文摘 | Tyrberg M Melander A Lovestam-Adrian M | 2008 | Diabetes Obes Metab2008，10，8： | 1 |
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