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| 1 | Genetic and biological characteristics of the globally circulating H5N8 avian influenza viruses and the protective efficacy offered by the poultry vaccine currently used in China显示文摘The H5N8 avian influenza viruses have been widely circulating in wild birds and are responsible for the loss of over 33 million domestic poultry in Europe, Russia, Middle East, and Asia since January 2020. To monitor the invasion and spread of the H5N8 virus in China, we performed active surveillance by analyzing 317 wild bird samples and swab samples collected from 41,172 poultry all over the country. We isolated 22 H5N8 viruses from wild birds and 14 H5N8 viruses from waterfowls. Genetic analysis indicated that the 36 viruses formed two different genotypes: one genotype viruses were widely detected from different wild birds and domestic waterfowls;the other genotype was isolated from a whopper swan. We further revealed the origin and spatiotemporal spread of these two distinct H5N8 virus genotypes in 2020 and 2021. Animal studies indicated that the H5N8 isolates are highly pathogenic to chickens, mildly pathogenic in ducks, but have distinct pathotypes in mice. Moreover, we found that vaccinated poultry in China could be completely protected against H5N8 virus challenge. Given that the H5N8 viruses are likely to continue to spread in wild birds, vaccination of poultry is highly recommended in high-risk countries to prevent H5N8 avian influenza. | Pengfei Cui Xianying Zeng Xuyong Li Yanbing Li Jianzhong Shi Conghui Zhao Zhiyuan Qu Yanwen Wang Jing Guo Wenli Gu Qi Ma Yuancheng Zhang Weipeng Lin Minghui Li Jingman Tian Dongxue Wang Xin Xing Yanjing Liu Shuxin Pan Yaping Zhang Hongmei Bao Liling Liu Guobin Tian Chengjun Li Guohua Deng Hualan Chen | 2022 | Science China(Life Sciences)2022，65，4： | 12 |
| 2 | RNA-seq analysis identified hormone-related genes associated with prognosis of triple negative breast cancer显示文摘Triple negative breast cancer(TNBC) is an aggressive subtype of breast cancer that currently lacks effective biomarkers and therapeutic targets required to investigate the diagnosis and treatment of TNBC. Here we performed a comprehensive differential analysis of 165 TNBC samples by integrating RNA-seq data of breast tumor tissues and adjacent normal tissues from both our cohort and The Cancer Genome Atlas(TCGA). Pathway enrichment analysis was conducted to evaluate the biological function of TNBC-specific expressed genes. Further multivariate Cox proportional hazard regression was performed to evaluate the effect of these genes on TNBC prognosis. In this report, we identified a total of 148 TNBC-specific expressed genes that were primarily enriched in mammary gland morphogenesis and hormone levels related pathways, suggesting that mammary gland morphogenesis might play a unique role in TNBC patients differing from other breast cancer types. Further survival analysis revealed that nine genes(FSIP1, ADCY5, FSD1, HMSD, CMTM5, AFF3, CYP2 A7, ATP1 A2,and C11 orf86) were significantly associated with the prognosis of TNBC patients, while three of them(ADCY5,CYP2 A7, and ATP1 A2) were involved in the hormone-related pathways. These findings indicated the vital role of the hormone-related genes in TNBC tumorigenesis and may provide some independent prognostic markers as well as novel therapeutic targets for TNBC. | Fei Chen Yuancheng Li Na Qin Fengliang Wang Jiangbo Du Cheng Wang Fangzhi Du Tao Jiang Yue Jiang Juncheng Dai Zhibin Hu Cheng Lu Hongbing Shen | 2020 | The Journal of Biomedical Research2020，34，2： | 4 |
| 3 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 4 | Low power and high uniformity of HfO_x-based RRAM via tip-enhanced electric fields显示文摘In this paper, the HfO_x-based resistive random access memory(RRAM) devices with sub-100 nm pyramid-type electrodes were fabricated. With the help of tip-enhanced electric field around the pyramid-type electrodes, it was experimentally demonstrated that the novel devices have better cycle-to-cycle variation control, lower forming/set voltage(1.97/0.7V) and faster switching speed(≤30 ns under 0.9V pulse) as well as better endurance reliability than conventional flat electrode resistive memory devices. In addition,the novel RRAM is experimentally demonstrated with independence of electrode number for the first time to present great potential in scaling down. This novel structure metal-oxide based RRAM will be suitable for the future low-power non-volatile memory application. | Xiaokang LI Baotong ZHANG Bowen WANG Xiaoyan XU Yuancheng YANG Shuang SUN Qifeng CAI Shijie HU Xia AN Ming LI Ru HUANG | 2019 | Science China(Information Sciences)2019，62，10： | 3 |
| 5 | A hybrid artificial bee colony assisted differential evolution algorithm for optimal reactive power flow显示文摘 | Yuancheng Li Yiliang Wang Bin Li | 2013 | International Journal of Electrical Power and Energy Systems2013，，： | 2 |
| 6 | Preparation and characterization of borosilicate glass-ceramics containing zirconolite and titanite crystalline phases显示文摘 | Lang Wu Yuxiang Li Yuancheng Teng Guolong Meng | 2013 | Journal of Non-Crystalline Solids2013，，： | 2 |
| 7 | An Improved Quantum Differential Evolution Algorithm for Optimization and Control in Power Systems Including DGs显示文摘 | Yuancheng Li Zongpu Li Liqun Yang Bei Wang | 2017 | 自动化学报2017，43，7： | 2 |
| 8 | PHISHING WEB IMAGE SEGMENTATION BASED ON IMPROVING SPECTRAL CLUSTERING显示文摘This paper proposes a novel phishing web image segmentation algorithm which based on improving spectral clustering.Firstly,we construct a set of points which are composed of spatial location pixels and gray levels from a given image.Secondly,the data is clustered in spectral space of the similar matrix of the set points,in order to avoid the drawbacks of K-means algorithm in the conventional spectral clustering method that is sensitive to initial clustering centroids and convergence to local optimal solution,we introduce the clone operator,Cauthy mutation to enlarge the scale of clustering centers,quantum-inspired evolutionary algorithm to find the global optimal clustering centroids.Compared with phishing web image segmentation based on K-means,experimental results show that the segmentation performance of our method gains much improvement.Moreover,our method can convergence to global optimal solution and is better in accuracy of phishing web segmentation. | Li Yuancheng Zhao Liujun Jiao Runhai | 2011 | Journal of Electronics(China)2011，28，1： | 1 |
| 9 | A hybrid artificial bee colo- ny assisted differential evolution algorithm for optimal reactive pow- er flow 显示文摘 | Yuancheng Li Yiliang Wang Bin Li | 2013 | Electrical Power and Energy Systems2013，52，： | 1 |
| 10 | hnage compression scheme based on curvelet transform and support w:ctor machine显示文摘 | Yuancheng Li Qiu Yang Runhai Jiao | 2010 | Expert Systems with Applications : An Inter- national Journal2010，37，4： | 1 |
| 11 | A misuse intrusion detection model based on hybrid classifier algorithm显示文摘 | Li Yuancheng Wang Yufei | 2012 | International Journal of Digital Content Technology and its Applications2012，6，5： | 1 |
| 12 | Fabrication and characterization of Ba Ce_(0.8)Y_(0.2)O_(2.9)-Ce_(0.85)Sm_(0.15)O_(1.925) composite electrolytes for IT-SOFCs显示文摘The Ba Ce0.8Y0.2O2.9-Ce0.85Sm0.15O1.925 composite electrolytes were prepared with Ba Ce0.8Y0.2O2.9(BCY) and Ce0.85Sm0.15O1.925(SDC). The SDC and BCY powders were mixed in the weight ratio of 95:5, 85:15, and 75:25, respectively(named as BS95, BS85, and BS75). Because of the composite effect between the SDC and BCY phases, the BS95 and BS85 exhibit improved conductivity compared with the pure SDC and BCY. The conductivity of BS95 is higher than that of BS85, indicating that the composite effect of BS95 is greater than that of BS85. Nevertheless, the composite effect in BS75 does not exist. Hence, we conclude that the composite effect in the BCY-SDC composites will decrease with the increase of the amount of BCY and even disappear when the amount of BCY exceeds a certain value. In our case, the optimum composition of the composite electrolyte is 95 wt% SDC and 5 wt% BCY. The BS95 has the highest conductivity(σ1t=0.07808 S cm-1, at 800 °C) and the fuel cell based on the BS95 shows the best performance(the maximum power density reaches as high as 526 mw cm-2 at 750 °C). The encouraging results suggest that the BCY-SDC composites are the very promising electrolyte materials for IT-SOFCs. | Ji Yu Ning Tian Yufu Deng Guannan Li Ling Liu Liying Cheng Peng Gao Qingchao Pan Yuancheng Wang Xiuyan Chen Kezhen Qi | 2015 | Science China Chemistry2015，58，3： | 1 |
| 13 | Hyperspectral Image Classification by Nonlocal Joint Collaborative Representation with a Locally Adaptive Dictionary显示文摘 | LI Jiayi ZHANG Hongyan HUANG Yuancheng | 2014 | IEEE Transactions on Geoscience and Remote Sensing2014，52，6： | 1 |
| 14 | Quantum chemical and topological study on the insertion reaction of dichlorcarbene with acetaldehyde显示文摘The insertion reaction mechanisms of siglet and striglet CCl2 with CH3CHO have been studied by using the DFT, NBO, CCSD(T) and AIM method. The geometries of reactions, transition state and products were completely optimized by B3LYP/6-31G(d). All the energy of the species was obtained at the CCSD(T)/6-31G(d,p) level. The calculated results indicated that all the major pathways of the reaction were obtained on the singlet potential energy surface. The singlet CCl2 can not only insert the Cα—H (reaction I) but also can react with Cβ—H (reaction Ⅱ). There are three main existing pathways and the products are P1 (CH3COHCCl2), P2 (CH2COHCHCl2) and P4[CHCl2CHCHOH] respectively. Reaction Ⅱ happens more easily according to the energy changes and the barrier in rate-controlling step. In addi-tion, the important geometries in domain pathways have been studied by AIM theory. And also, the en-ergy changes of H in the inserted C—H bond have been investigated. | LI ZhiFeng ZHU YuanCheng YANG Sheng LU XiaoQuan | 2008 | Chinese Science Bulletin2008，53，15： | 1 |
| 15 | Comprehensive analysis of differential genes andmiRNA profiles for discovery of topping-responsivegenes in flue-cured tobacco roots显示文摘 | Qi Yuancheng GuoHongxiang Li Ke etal | 2012 | The FEBS journal2012，279，6： | 1 |
| 16 | Subwavelength optical localization with toroidal excitations in plasmonic and Mie metamaterials显示文摘Since the performance of electronic circuits is becoming rather limited in face of intensively increasing of amount of information and related operations,alloptical processing offers a promising strategy for future information system.It would benefit a great deal if the all-optical processing could be implemented within the developed electronic chips of nanoscale structures.In that it is highly desirable to break the diffraction limit of light for achieving effective light manipulations with deep subwavelength structures compatible with the state-of-the-art nanofabrication processes.It is of fundamental importance to get subwavelength optical localization,that is,squeeze light wave into subwavelength space for achieving freely manipulating of light fields.This review summarizes the development in realizing subwavelength optical localization by exciting toroidal mode in photonic metamaterials.The toroidal excitations in plasmonic metamaterials and Mie resonant metamaterials,in 3D structures and planar metamaterials,with single or few layers in spectral regime from microwave to optical frequencies are surveyed.Based on the discussion on the configurations of toroidal excitations,the recent development on toroidalrelated optical scattering control actively manipulates the toroidal excitations,and promising applications are further investigated and highlighted. | Ruisheng Yang Jing Xu Nian-Hai Shen Fuli Zhang Quanhong Fu Junjie Li Hongqiang Li Yuancheng Fan | 2021 | InfoMat2021，3，5： | 1 |
| 17 | Identification of A-to-I RNA editing profiles and their clinical relevance in lung adenocarcinoma显示文摘Adenosine-to-inosine(A-to-I)RNA editing is a widespread posttranscriptional modification that has been shown to play an important role in tumorigenesis.Here,we evaluated a total of 19,316 RNA editing sites in the tissues of 80 lung adenocarcinoma(LUAD)patients from our Nanjing Lung Cancer Cohort(NJLCC)and 486 LUAD patients from the TCGA database.The global RNA editing level was significantly increased in tumor tissues and was highly heterogeneous across patients.The high RNA editing level in tumors was attributed to both RNA(ADAR1 expression)and DNA alterations(mutation load).Consensus clustering on RNA editing sites revealed a new molecular subtype(EC3)that was associated with the poorest prognosis of LUAD patients.Importantly,the new classification was independent of classic molecular subtypes based on gene expression or DNA methylation.We further proposed a simplified model including eight RNA editing sites to accurately distinguish the EC3 subtype in our patients.The model was further validated in the TCGA dataset and had an area under the curve(AUC)of the receiver operating characteristic curve of 0.93(95%CI:0.91-0.95).In addition,we found that LUAD cell lines with the EC3 subtype were sensitive to four chemotherapy drugs.These findings highlighted the importance of RNA editing events in the tumorigenesis of LUAD and provided insight into the application of RNA editing in the molecular subtyping and clinical treatment of cancer. | Cheng Wang Mingtao Huang Congcong Chen Yuancheng Li Na Qin Zijian Ma Jingyi Fan Linnan Gong Hui Zeng Liu Yang Xianfeng Xu Jun Zhou Juncheng Dai Guangfu Jin Zhibin Hu Hongxia Ma Fengwei Tan Hongbing Shen | 2022 | Science China(Life Sciences)2022，65，1： | 1 |
| 18 | High-resolution Hyper-spectral Image Classification with Parts-based Feature and Morphology Profile in Urban Area显示文摘High-resolution hyper-spectral image (HHR) provides both detailed structural and spectral information for urban study. However, due to the inherent correlation between spectral bands and within-class variability in the data, the data processing of HHR is a challenging work. In this paper, based on spectral mixture analysis theory, a new stack of parts description features were extracted, and then incorporated with a stack of morphology based spatial features. Partially supervised constrained energy minimization (CEM) and unsupervised nonnegative matrix factorization (NMF) were used to extract the part-features. The joint features were then integrated by SVM classifier. The advantages of this method are the representation of physical composition of the urban area by the parts-features and the show of multi-scale structure information by morphology profiles. Experiments with an airborne hyper-spectral data flightline over the Washington DC Mall were performed, and the performance of the proposed algorithm was evaluated in comparison with well-known nonparametric weighted feature extraction (NWFE) and feature selection method. The results shown that the proposed features-joint scheme consistently outperforms the traditional methods, and so can provide an effective option for processing HHR data in urban area. | HUANG Yuancheng ZHANG Liangpei LI Pingxiang ZHONG Yanfei | 2010 | Geo-Spatial Information Science2010，13，2： | 1 |
| 19 | Experimental study and numerical simulation analysis of composite foundation with long - short piles 显示文摘 | GUO Yuancheng ZHANG Sihua LI Mingyu | 2010 | Journal of Geotechnical Engineering2010，32，2： | 1 |
| 20 | Theoretical study of the charge carrier mobilities of the molecular materials tetrathiafulvalene (TTF) and 2,5-bis(1,3-dithiolan-2-ylidene)-1,3,4,6-tetrathiapentalene (BDH-TTP)显示文摘Tetrathiafulvalene (TTF) is a kind of fused ring aromatic compound containing four sulfur atoms in one molecule, which is well known as a charge transport material. In order to calculate the charge mobility of this semiconductor, Marcus electron transfer theory and the embedded model, which can give small intramolecular reorganization energies, were employed. The calculated results were in good agreement with the experimental values, so the above computing model is appropriate to assess the electrical property of TTF. On this basis, we predicted the charge mobility of 2,5-bis(1,3-dithiolan-2-ylidene)-1,3,4,6-tetrathiapentalene (BDH-TTP) crystals, for which the molecular structure is similar to TTF. The calculated results indicated that BDH-TTP is a p-type material, which has a better performance than TTF in hole transfer due to larger hole coupling and the smaller hole injection barrier. In addition, the direct coupling (DC) and the site energy correction (SEC) methods were used to calculate the charge transfer integrals. Although the results were slightly different, the qualitative trends were the same. Furthermore we took into account the anisotropic transfer properties of TTF and BDH-TTF, since obviously the mobilities along one dimension are larger than those along three dimensions. Finally, natural bond orbital analysis was used to study the interactions in all of the dimers. | LI HuiXue WANG XiaoFeng LI ZhiFeng ZHENG RenHui ZHU YuanCheng | 2012 | Science China Chemistry2012，55，10： | 1 |
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