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61篇 您的检索式：作者名="Mello W"

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	题名	作者	年代	出处	被引量
1	Antidiabetic thiazolidinediones induce ductal differentiation but not apoptosis in pancreatic cancer cells显示文摘AIM: Thiazolidinediones (TZD) are a new class of oral antidiabetic drugs that have been shown to inhibit growth of same epithelial cancer cells. Although TZD were found to be ligands for peroxisome proliferator-activated receptor γ (PPARγ), the mechanism by which TZD exert their anticancer effect is presently unclear. In this study,we analyzed the mechanism by which TZD inhibit growth of human pancreatic carcinoma cell lines in order to evaluate the potential therapeutic use of these drugs in pancreatic adenocarcinoma.METHODS: The effects of TZD in pancreatic cancer cells were assessed in anchorage-independent growth assay.Expression of PPARγ was measured by reverse-transcription polymerase chain reaction and confirmed by Western blot analysis. PPARγ activity was evaluated by transient reporter gene assay. Flow cytometry and DNA fragmentationassay were used to determine the effect of TZD on cell cycle progression and apoptosis respectively. The effect of TZD on ductal differentiation markers was performed by Western blot.RESULTS: Exposure to TZD inhibited colony formation in a PPARγ-dependent manner. Growth inhibition was linked to G1 phase cell cycle arrest through induction of the ductal differentiation program without any increase of the apoptotic rate.CONCLUSION: TZD treatment in pancreatic cancer cells has potent inhibitory effects on growth by a PPAR-dependent induction of pacreatic ductal differentiation.	Elisabetta Ceni Tommaso Mello Mirko Tarocchi David W Crabb Anna Caldini Pietro Invernizzi Calogero Surrenti Stefano Milani Andrea Galli	2005	World Journal of Gastroenterology2005，11，8：	15
2	Simulating fast and slow dynamic effect in power systems显示文摘	de Mello F P Feltes J W Laskowski T F	1992	Computer Applications in Power IEEE1992，5，3：	1
3	Simulation fast and slow dynamic effects in power system显示文摘	Mello F P Feltes J W Laskowski T F	1992	IEEE Computer Applications in Power1992，5，3：	1
4	Ab- sorption of CO2 into aqueous solutions of MEA and AMP in a wetted wall column with film promoter Chemical 显示文摘	MELLO L C SALVAGNINI W M DE PAIVA J L	2013	Engineering and Processing: Process Intensifica- tion2013，73，12：	1
5	What is a public health 'emergency'显示文摘	HAFFAJEE R PARMET W E MELLO M M	2014	The New England Journal of Medicine2014，371，11：	1
6	On the pathophysiological implications of an intra- cellular renin receptor显示文摘	De Mello W C	2006	Circ Res2006，99，12：	1
7	Relative molecular weight and concentration determination of sodium hyaluronate solutions by gel-exclusion high performance liquid chromatography显示文摘	Beaty N B Tew W P Mello R J	1985	Anal Biochem1985，147，：	1
8	Impacts of climate warming on lake fish community structure and potential effects on ecosystem function显示文摘	Jeppesen E Meerhoff M Holmgren K Gonzalez-Bergonzoni I Teixeira-de Mello F Declerck S A J De Meester L S?ndergaard M Lauridsen T L Bjerring R Conde-Porcuna J M Mazzeo N Iglesias C Reizenstein M Malmquist H J Liu Z W Balayla D Lazzaro X	2010	Hydrobiologia2010，646，1：	1
9	Electricity market design: an integrated approach to reliability assur- ance 显示文摘	CHOW J de MELLO R W CHEUNG K W	2005	Proceedings of the IEEE2005，93，11：	1
10	Angiotensin Ⅱ and the heart:on the intracrine renin-angiotensin system显示文摘	De Mello W C Danser A H	2000	Hypertension2000，35，：	1
11	Phosphorus and iron mobilization in flooded soils from Brazil显示文摘	MELLO J W V BARRON V TORRENT J	1998	Soil Sci1998，163，2：	1
12	The groundwater supply survey显示文摘	Westrick J J Mello J W Thomas R F	1984	J Am Water Works Assoc1984，76，5：	1
13	Grounded Theory:An Inductive Method for Supply Chain Research 显示文摘	RANDALL W S MELLO J E	2012	International Journal of Physical Distribution & Logistics Management2012，42，89：	1
14	Electricity market design: an integrated approach to reliability assurance显示文摘	J H Chow R de Mello K W Cheung	2005	IEEE Proceeding2005，93，：	1
15	显示文摘	De Mello W Altieti P	1992	J Cardiovasc Pharmacol1992，20，4：	1
16	Bene impulse ficial and cardiac arrhythmias in the failing heart显示文摘	De Mello W C Ferrario C M Jessup harmful effects of Angiotensin (1-7) on A	2007	J Renin Angio tensin Aldosterone Syst2007，8，：	1
17	Theeffect of stocking density on Macrobrachium rosenbergii(De Man)growth curves in earthen ponds(Crustacea,Palaemonidae)显示文摘	VALENTI W C MELLO J T CASTAGNOLLI N	1993	Revista Brasileira De Zoologia1993，10，3：	1
18	short term variability in biogenic sulfur emissions from a Florida spartina alterniflora marsh显示文摘	D J De Mello W Z Cooper W J Zika Q G Saltzman E J Prospero M and Savoie D L	1987	Atmos Environ1987，21，：	1
19	The effeet of stocking density on Macrobrachium rosenbergii (De Man) growth curves in earthen ponds(Crustacea, Palaemonidae)显示文摘	Cotroni V W De Toledo Cardoso de Mello J Castagnolli N	1993	Revista Brasileira De Zoologia1993，10，3：	1
20	Definition of the primary structure of hepatitis B virus (HBV) pre-S hepatocyte binding domain using random peptide libraries显示文摘	D'Mello Partidos C D Steward M W	1997	Virology1997，237，2：	1

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