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| 1 | A novel protein-repellent dental composite containing 2-methacryloyloxyethyl phosphorylcholine显示文摘Secondary caries due to biofilm acids is a primary cause of dental composite restoration failure.To date,there have been no reports of dental composites that can repel protein adsorption and inhibit bacteria attachment.The objectives of this study were to develop a protein-repellent dental composite by incorporating 2-methacryloyloxyethyl phosphorylcholine(MPC) and to investigate for the first time the effects of MPC mass fraction on protein adsorption,bacteria attachment,biofilm growth,and mechanical properties.Composites were synthesized with 0(control),0.75%,1.5%,2.25%,3%,4.5%and 6%of MPC by mass.A commercial composite was also tested as a control.Mechanical properties were measured in three-point flexure.Protein adsorption onto the composite was determined by the microbicinchoninic acid method.A human saliva microcosm biofilm model was used.Early attachment at 4 h,biofilm at 2 days,live/dead staining and colony-forming units(CFUs) of biofilms grown on the composites were investigated.Composites with MPC of up to 3%had mechanical properties similar to those without MPC and those of the commercial control,whereas 4.5%and 6%MPC decreased the mechanical properties(P<0.05).Increasing MPC from 0 to 3%reduced the protein adsorption on composites(P<0.05).The composite with 3%MPC had protein adsorption that was 1/12 that of the control(P<0.05).Oral bacteria early attachment and biofilm growth were also greatly reduced on the composite with 3%MPC,compared to the control(P<0.05).In conclusion,incorporation of MPC into composites at 3%greatly reduced protein adsorption,bacteria attachment and biofilm CFUs,without compromising mechanical properties.Protein-repellent composites could help to repel bacteria attachment and plaque build-up to reduce secondary caries.The protein-repellent method might be applicable to other dental materials. | Ning Zhang Chen Chen Mary AS Melo Yu-Xing Bai Lei Cheng Hockin HK Xu | 2015 | International Journal of Oral Science2015，7，2： | 8 |
| 2 | Molecular and cell-based therapies for protection, rescue, and repair of ischemic myocardium: reasons for cautious optimism显示文摘 | Melo LG Pachori AS Kong D | 2004 | Circulation2004，109，20： | 1 |
| 3 | Molecular and cell-based therapies for protection, rescue, and repair of ischemic myocardium: reasons for cautious optimism 显示文摘 | Melo LG Pachori AS Kong D | 2004 | Circulation2004，109，： | 1 |
| 4 | Detection and typification of human papilloma virus in pre cancerous cervical lesions 显示文摘 | Aedo AS Melo AA Garcia P | 2007 | Rev Med Chil2007，135，： | 1 |
| 5 | Chronic recurrent myocardial ischemic injury is significantly attenuated by preemptive adeno-associated virus heine oxygenase-1 gene delivery 显示文摘 | Pachori AS Melo LG Zhang L | 2006 | J Am Coil Cardiol2006，47，3： | 1 |
| 6 | Gene and cell-based therapies for heart disease显示文摘 | PACHORI AS KONG D | 2004 | FASEB J2004，18，6： | 1 |
| 7 | Molecular and cel-based therapies for protection,rescue,and repair of ischemic myocardium:reasons for cautious optimism显示文摘 | Melo LG Pachori AS Kong D | | 0，，20： | 1 |
| 8 | Endothelium-targeted gene and cell-based therapies for cardiovascular disease 显示文摘 | Melo LG Gnecchi M Pachofi AS | 2004 | Arterioscler Thromb Vase Biol2004，24，10： | 1 |
| 9 | Oocyte diameter as a predictor of fertilization and embryo quality in assisted reproduction cycles 显示文摘 | Romeo GS Aratjo MC de Melo AS | 2010 | FertilSteril2010，93，2： | 1 |
| 10 | Chronic recurrent myocardial ischemic injury is significantly attenuated by pre-emptive adeno-associated virus heine oxygenase-1 gene delivery显示文摘 | Pachori AS Melo LG Zhang L el al | 2006 | J Am Coil Cardiol2006，47，3： | 1 |
| 11 | Molecular and cell-based therapies for protection,rescue,and repair of ischemic myocardium,reasons for cautious optimism显示文摘 | Melo LG Pachori AS Kong D | 2004 | Circulation2004，109，： | 1 |
| 12 | Small for gestational age babies are not related to changes in markers of adipose tissue dysfunction during reproductive age显示文摘 | Melo AS Bettiol H Silva AA | 2014 | Early Hum Dev2014，90，5： | 1 |
| 13 | Zika vi rus intrauterine infection causes fetal brain abnormality and microcephaly:tip of the iceberg? 显示文摘 | Oliveira Melo AS Malinger G Ximenes R | 2016 | Ultrasound Obstct Gynecol2016，47，1： | 1 |
| 14 | Treatment of aggressive well-differentiated thyroid cancer显示文摘 | Martins AS Melo GM Valerio JB | 2001 | Int Surg2001，86，4： | 1 |
| 15 | Hypoxia-regulated therapeutic gene as a preemptive treatment strategy against isehemia/reperfusion tissue Injury显示文摘 | Pachori AS Melo LG Hart ML Noiseux N Zhang L Morello F | 2004 | Proc Natl Acad Sci USA2004，101，12： | 1 |
| 16 | Gene and cell-based therapies for heart disease 显示文摘 | Melo LG Pachori AS Kong D | 2004 | FASEB J2004，18，6： | 1 |
| 17 | Genetic therapies for cardiovascular diseases显示文摘 | Melo LG Pachori AS Gnecchi M | | 0，，05： | 1 |
| 18 | Chronic recurrent myo- cardial ischemic injury is significantly attenuated by pre-emptive adeno-associated virus heme oxygenase-1 gene delivery显示文摘 | Pachori AS Melo LG Zhang L | 2006 | J Am Coll Cardiol2006，47，3： | 1 |
| 19 | Chronic recurrent myocardial ischemic injury is significantly attenuated by pre-emptive adeno-associated virus heme oxygenase-1 gene delivery 显示文摘 | Pachori AS Melo LG Zhang L | 2006 | J Am Coll Cardiol2006，47，3： | 1 |
| 20 | Defining quantitative stream disturbance gradients and the additive role of habitat variation to explain macroinvertebrate taxa richness 显示文摘 | Ligeiro RL Hughes RM Kaufmann PR Macedo DR Firmiano KR Ferreira WR Oliveira D Melo AS Callisto M | 2013 | Ecol Indic2013，25，： | 1 |
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