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| 1 | Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice显示文摘AIM To investigate the effect of probiotic supplementation during the development of an experimental model of colitis associated colon cancer(CAC). METHODS C57 BL/6 mice received an intraperitoneal injection of azoxymethane(10 mg/kg), followed by three cycles of sodium dextran sulphate diluted in water(5% w/v). Probiotic group received daily a mixture of Lactobacillus acidophilus, Lactobacil us rhamnosus and Bifidobacterium bifidum. Microbiota composition was assessed by 16 Sr RNA Illumina Hi Seq sequencing. Colon samples were collected for histological analysis. Tumor cytokines was assessed by Real Time-PCR(Polymerase Chain Reaction); and serum cytokines by Multiplex assay. All tests were two-sided. The level of significance was set at P < 0.05. Graphs were generated and statistical analysis performed using the software Graph Pad Prism 5.0. The project was approved by the institutional review board committee. RESULTS At day 60 after azoxymethane injection, the mean number of tumours in the probiotic group was 40% lower than that in the control group, and the probiotic group exhibited tumours of smaller size(< 2 mm)(P < 0.05). There was no difference in richness and diversity between groups. However, there was a significant difference in beta diversity in the multidimensional scaling analysis. The abundance of the genera Lactobacillus, Bifidobacterium, Allobaculum, Clostridium XI and Clostridium XVⅢ increased in the probiotic group(P < 0.05). The microbial change was accompanied by reduced colitis, demonstrated by a 46% reduction in the colon inflammatory index; reduced expression of the serum chemokines RANTES and Eotaxin; decreased p-IKK and TNF-α and increased IL-10 expression in the colon. CONCLUSION Our results suggest a potential chemopreventive effect of probiotic on CAC. Probiotic supplementation changes microbiota structure and regulates the inflammatory response, reducing colitis and preventing CAC. | Maria Carolina S Mendes Daiane SM Paulino Sandra R Brambilla Juliana A Camargo Gabriela F Persinoti José Barreto C Carvalheira | 2018 | World Journal of Gastroenterology2018，24，18： | 17 |
| 2 | Obstruction of pipelines due to paraffin deposition during the flow of crude oils显示文摘 | Ribeiro F S Mendes P R S Braga S L | 1997 | International Journal of Heat Mass Transfer1997，18，1： | 1 |
| 3 | Modeling and ride-through control of doubly fed induction generators during symmetrical voltage sags显示文摘 | Mendes V F de Sousa C V Silva S R | 2011 | IEEE Transactions on Energy Conversion2011，26，4： | 1 |
| 4 | Supercritical C02 extraction of γ-linolenie acid and other lipids from Arthrospira (Spirulina) maxima: Comparison with organic solvent extraction 显示文摘 | Mendes R L Reis A D Palavra A F | 2006 | Food Chemistry2006，99，1： | 1 |
| 5 | Liquid displacement during oil well cementing operations 显示文摘 | Dutra E S S Naccache M F Mendes P R S | 2004 | Annual Transactions of the Nordic Rheology Society2004，12，1： | 1 |
| 6 | The novel biomarkergrowth differentiation factor 15 in heart failure with normal ejectionfraction显示文摘 | Stahrenberg R Edelmann F Mende M | 2010 | Eur J Heart Fail2010，12，2： | 1 |
| 7 | Sodium hyaluronate accelerates the healing process in tooth sockets of rats显示文摘 | Mendes R M Silva G A Lima M F et a1 | 2008 | Arch Oral Biol2008，53，12： | 1 |
| 8 | Genetic fuzzy system for data-driven soft sensors design显示文摘 | Mendes J Souza F Araujo R | 2012 | Applied Soft Computing2012，12，10： | 1 |
| 9 | The novel biomarker growth differentiation factor 15 in heart failure with normal ejection fraction显示文摘 | Stahrenberg R Edelmann F Mende M | | 0，，12： | 1 |
| 10 | Modeling and Simulation of Wind Shear and Tower Shadow on Wind Turbines显示文摘 | Sintra H Mendes V M F Melício R | 2014 | Procedia Technology2014，，17： | 1 |
| 11 | Fractionalorder control and simulation of wind energy systems with PMSG/full-power converter topology显示文摘 | Melício R Mendes V M F Catal觔o J P S | 2010 | Energy Conversion and Management2010，51，： | 1 |
| 12 | Pre-determination of the epexidation degree of polydienes using methyltrioxorhenium-CH2 CL2/H2O2 biphasic catalytic system显示文摘 | Gregorio J R Gerbasf A E Mendes A N F | 2005 | Reactive & Functional Polymers2005，64，2： | 1 |
| 13 | Liquiddisplacement during oil well cementing operations显示文摘 | DUTRA E S S NACCACHE M F MENDES P R S | 2004 | Annual transactions of the Nordic Rheology Society2004，12，1： | 1 |
| 14 | Moisture effects on conduction loads 显示文摘 | Mendes N Winkelmann F C Lamberts R | 2003 | Energy and Buildings2003，35，： | 1 |
| 15 | Transgenie tobacco revealing altered bacterial diver- sity in the rhizosphere during early plant develop- ment显示文摘 | Andreote F D Mendes R Dini Andreote F | 2008 | Antonie van Leeuwenhoek2008，93，4： | 1 |
| 16 | Association of glucose metabolism with diastolic function along the diabetic continuum显示文摘 | Stahrenberg R Edelmann F Mende M | 2010 | Diabetologia2010，53，7： | 1 |
| 17 | Power converter topologies for wind energy conversion systems:Integrated modeling,control strategy and performance simulation显示文摘 | Mel cio R Mendes V M F Catal o J P S | 2010 | Renewable Energy2010，35，10： | 1 |
| 18 | Elevated serum IgG4concentration in patients with primary sclerosing cholangitis显示文摘 | Mendes F D Jorgensen R Keach J | 2006 | Am J Gastroenterol2006，101，9： | 1 |
| 19 | Resistive force of wax deposits during pigging operations显示文摘 | MENDES P R S BRAGA A M B AZEVEDO L F A | 1999 | J Energy Resour-ASME1999，121，3： | 1 |
| 20 | ANew Constitutive Equation and its Performance in Con-traction Flows 1显示文摘 | Thompson R L Souza Mendes P R Naccache M F | 1999 | Journal of Non-newtonian Fluid Me-chanics1999，86，3： | 1 |
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