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| 1 | Neutrophile-to-lymphocyte,lymphocyte-to-monocyte,and platelet-tolymphocyte ratios as prognostic and response biomarkers for resectable locally advanced gastric cancer显示文摘BACKGROUND Perioperative fluorouracil plus leucovorin,oxaliplatin,and docetaxel(FLOT)improves prognosis in locally advanced gastric cancer(LAGC).Neutrophil-to-lymphocyte(NLR),lymphocyte-tomonocyte(LMR),and platelet-to-lymphocyte(PLR)ratios are prognostic biomarkers but not predictive factors.AIM To assess blood ratios’(NLR,LMR and PLR)potential predictive response to FLOT and survival outcomes in resectable LAGC patients.METHODS This was a multicentric retrospective study investigating the clinical potential of NLR,LMR,and PLR in resectable LAGC patients,treated with at least one preoperative FLOT cycle,from 12 Portuguese hospitals.Means were compared through non-parametric Mann-Whitney tests.Receiver operating characteristic curve analysis defined the cut-off values as:High PLR>141 for progression and>144 for mortality;high LMR>3.56 for T stage regression(TSR).Poisson and Cox regression models the calculated relative risks/hazard ratios,using NLR,pathologic complete response,TSR,and tumor regression grade(TRG)as independent variables,and overall survival(OS)as the dependent variable.RESULTS This study included 295 patients(mean age,63.7 years;59.7% males).NLR was correlated with survival time(r=0.143,P=0.014).PLR was associated with systemic progression during FLOT(P=0.022)and mortality(P=0.013),with high PLR patients having a 2.2-times higher risk of progression[95% confidence interval(CI):0.89-5.26]and 1.5-times higher risk of mortality(95%CI:0.92-2.55).LMR was associated with TSR,and high LMR patients had a 1.4-times higher risk of achieving TSR(95%CI:1.01-1.99).OS benefit was found with TSR(P=0.015)and partial/complete TRG(P<0.001).Patients without TSR and with no evidence of pathological response had 2.1-times(95%CI:1.14-3.96)and 2.8-times(95%CI:1.6-5)higher risk of death.CONCLUSION Higher NLR is correlated with longer survival time.High LMR patients have a higher risk of decreasing T stage,whereas high PLR patients have higher odds of progressing under FLOT and dying.Patients with TSR and a pathological response have better OS and lower risk of dying. | Tiago Cruz Tomás Ines Eiriz Marina Vitorino Rodrigo Vicente Joao Gramaca Alicia Guadalupe Oliveira Paulo Luz Mafalda Baleiras Ana Sofia Spencer Luísa Leal Costa Patrícia Liu Joana Mendonca Magno Dinis Teresa Padrao Marisol Correia Goncalo Atalaia Michelle Silva Teresa Fiúza | 2022 | World Journal of Gastrointestinal Oncology2022，14，7： | 2 |
| 2 | Bioconversion ofapple pomace into a nutritionally enriched substrate by Candida utilis andPleurotus ostreatus显示文摘 | VILLAS-BOAS S G ESPOSITO E MENDONCA M M | 2003 | World Journal of Microbiology&Biotechnology2003，19，： | 1 |
| 3 | Palm- CIS: A wireless handheld application for satisfying clinician infor- mation needs显示文摘 | Chen Elizabeth S Mendonca E A McKnight L K | 2004 | Journal of the American Medical Informatics As- sociation2004，11，1： | 1 |
| 4 | Robust Ck/C0 generalized FEM approximations for higher-order conformity requirements:Appfication to Reddy's HSDT model for anisotropic laminated plates thoery显示文摘 | Mendonca P T R Barcellos C S Torres DAF | 2013 | Compos Struct2013，，96： | 1 |
| 5 | A Simple Technique for Self- Calibration 显示文摘 | Mendonca S Cipolla R | 1999 | IEEE Computer Society Conference on Computer Vision and Pattern Recognition1999，1，： | 1 |
| 6 | Bioconversionof apple pomace into a nutritionally enriched substrate by Candi-da utilis and Pleurotus ostreatus显示文摘 | Villas-Boas S G Esposito E de Mendonca M M | 2003 | World Journal of Microbiolo-gy&Biotechnology2003，19，5： | 1 |
| 7 | Oxidative stressexpression status associated to Helicobacter pylori virulencein gastric diseases显示文摘 | Augusto A C Miguel F Mendonca S | 2007 | Clin Biochem2007，40，910： | 1 |
| 8 | Major peptides from amaranth (Amaranthus cruentus ) protein inhibit HMG- CoA reductase activity显示文摘 | Soares RA Mendonca S de Castro L | 2015 | Int J Mol Sci2015，16，： | 1 |
| 9 | Modeling of droplet dynamic and thermal behavior during spray deposition 显示文摘 | MAHESH N S MENDONCA J MURALIDHARA M K | 2003 | Indian Academy of Sciences2003，26，3： | 1 |
| 10 | Modeling of droplet dynamic and thermal behavior during spray deposition 显示文摘 | Mendonca Johnson Mahesh N S Muralidhara M K | 2003 | Mater Science Bull2003，26，3： | 1 |
| 11 | Time course of platelet counts in critically ill patients 显示文摘 | AKCA S HAJI MICHAEL P DE MENDONCA A | 2002 | Crit Care Med2002，30，4： | 1 |
| 12 | Tile ex- pression level of luciferase within tumour cells can alter tumour growth upon in vivo bioluminescence imaging 显示文摘 | Brutkiewicz S Mendonca M Stantz K | | The Journal of Biological and Chemical Lumines- cence0，22，3： | 1 |
| 13 | Time course of platelet counts in critically ill patients显示文摘 | Akca S Haji-Michael P de Mendonca A | 2002 | Crit Care Med2002，30，4： | 1 |
| 14 | Brave old world: Accounting for 'high -tech' knowledge in 'low - tech' industries 显示文摘 | Mendonca S | 2009 | Research Policy2009，38，3： | 1 |
| 15 | When social issues become strategic 显示文摘 | BONINI S MENDONCA L OPPENHEIM J | 2006 | The Mckinsey Quarterly2006，，2： | 1 |
| 16 | Time course of platelet counts in critically ill patients 显示文摘 | Akca S Haji-Michael P de Mendonca A | 2002 | Crit Care Med2002，30，4： | 1 |
| 17 | On digital soil mapping显示文摘 | McBratney A B Mendonca S M L Minasny B | | 0，，1： | 1 |
| 18 | A comparative eval- uation of methodologies for water content determination in green coffee显示文摘 | Mendonca J C F Franca A S Oliveira L S | 2007 | LWT Food Science and Technology2007，40，7： | 1 |
| 19 | Time course of platelet counts in critically patients显示文摘 | Akca S Haji-Michael P de Mendonca A | 2002 | Crit Care Med2002，30，4： | 1 |
| 20 | Prevalence of Helicobacter pylori resistance to metronidazole, clarithromycin, amoxicillin, tetracycline, and furazolidone in Brazil 显示文摘 | Mendonca S Ecclissato C Sartori MS | 2000 | Helicobacter2000，5，1： | 1 |
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