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您的检索式：作者名="Mengdie Bao"
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| 1 | Nanoscale engineering of conducting polymers for emerging applications in soft electronics显示文摘Soft electronics featuring exceptional mechanical compliance and excellent electrical performance hold great promise for applications in soft robotics,artificial intelligence,bio-integrated electronics,and wearable electronics.Intrinsically stretchable and conductive materials are crucial for soft electronics,enabling large-area and scalable fabrication,high device density,and good mechanical compliance.Conducting polymers are inherently stretchable and conductive.They can be precisely synthesized from vastly available building blocks,and thus they provide a fruitful platform for fabricating soft electronics.However,amorphous bulk-phase conducting polymers typically exhibit poor mechanical and electrical characteristics.Consequently,it is highly desirable to develop novel engineering approaches to overcome the intrinsic limitations of conducting polymers.In recent years,numerous engineering strategies have been developed to enhance their performances in soft electronic devices via constructing various nanostructures.In this review,we first summarize several unique methodologies to fabricate conducting polymer-based nanostructures.We then discuss how nanoscale engineering approaches can improve several crucial parameters,including electrical conductivity,stretchability,sensitivity,and self-healing property of conducting polymers.Moreover,we also discuss device-level integration of conducting polymer-based nanostructures with other materials for applications in skin-inspired electronics and bio-integrated electronics.Finally,we provide perspectives on challenges and future directions in engineering nanostructured conducting polymers for soft electronics. | Tao Wang Yiwen Bao Mengdi Zhuang Jiacheng Li Juncheng Chen Hangxun Xu | 2021 | Nano Research2021，14，9： | 3 |
| 2 | Stochastic analysis of excavation-induced wall deflection and box culvert settlement considering spatial variability of soil stiffness显示文摘In this study, a three-dimensional (3D) finite element modelling (FEM) analysis is carried out to investigate the effects of soil spatial variability on the response of retaining walls and an adjacent box culvert due to a braced excavation. The spatial variability of soil stiffness is modelled using a variogram and calibrated by high-quality experimental data. Multiple random field samples (RFSs) of soil stiffness are generated using geostatistical analysis and mapped onto a finite element mesh for stochastic analysis of excavation-induced structural responses by Monte Carlo simulation. It is found that the spatial variability of soil stiffness can be described by an exponential variogram, and the associated vertical correlation length is varied from 1.3 m to 1.6 m. It also reveals that the spatial variability of soil stiffness has a significant effect on the variations of retaining wall deflections and box culvert settlements. The ignorance of spatial variability in 3D FEM can result in an underestimation of lateral wall deflections and culvert settlements. Thus, the stochastic structural responses obtained from the 3D analysis could serve as an effective aid for probabilistic design and analysis of excavations. | Ping Li Shiwei Liu Jian Ji Xuanming Ding Mengdie Bao | 2023 | Journal of Rock Mechanics and Geotechnical Engineering2023，15，12： | 0 |
| 3 | Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors显示文摘Fibroblast growth factor receptors (FGFRs) have emerged as promising targets for anticancer therapy.In this study,we synthesized and evaluated the biological activity of 66 pyrazolo[3,4-d]pyridazinone derivatives.Kinase inhibition,cell proliferation,and whole blood stability assays were used to evaluate their activity on FGFR,allowing us to explore structureàactivity relationships and thus to gain understanding of the structural requirements to modulate covalent inhibitors’selectivity and reactivity.Among them,compound 10h exhibited potent enzymatic activity against FGFR and remarkably inhibited proliferation of various cancer cells associated with FGFR dysregulation,and suppressed FGFR signaling pathway in cancer cells by the immunoblot analysis.Moreover,10h displayed highly potent antitumor efficacy (TGI Z 91.6%,at a dose of 50 mg/kg) in the FGFR1-amplified NCI-H1581 xenograft model. | Xiaowei Wu Mengdi Dai Rongrong Cui Yulan Wang Chunpu Li Xia Peng Jihui Zhao Bao Wang Yang Dai Dan Feng Tianbiao Yang Hualiang Jiang Meiyu Geng Jing Ai Mingyue Zheng Hong Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，3： | 0 |
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