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| 1 | Evaluation of latent links between irritable bowel syndrome and sleep quality显示文摘AIM:To examine the links between quality of sleep and the severity of intestinal symptoms in irritable bow-el syndrome(IBS).METHODS:One hundred and forty-two outpatients(110female,32 male)who met the Rome Ⅲ criteria for IBS with no psychiatric comorbidity were consecutively en-rolled in this study.Data on age,body mass index(BMI),and a set of life-habit variables were recorded,and IBS symptoms and sleep quality were evaluated using the questionnaires IBS Symptom Severity Score(IBS-SSS)and Pittsburgh Sleep Quality Index(PSQI).The associa-tion between severity of IBS and sleep disturbances was evaluated by comparing the global IBS-SSS and PSQI score(Pearson's correlation and Fisher's exact test)and then analyzing the individual items of the IBS-SSS and PSQI questionnaires by a unitary bowel-sleep model based on item response theory(IRT).RESULTS:IBS-SSS ranged from mild to severe(120-470).The global PSQI score ranged from 1 to 17(median 5),and 60 patients were found to be poor sleepers(PSQI>5).The correlation between the global IBS-SSS and PSQI score indicated a weak association(r=0.2 and 95% CI:-0.03 to 0.35,P<0.05),which becomes stronger using our unitary model.Indeed,the IBS and sleep disturbances severities,estimated as latent variables,resulted significantly high intra-subject cor-relation(posterior mean of r=0.45 and 95% CI:0.17 to 0.70,P<0.05).Moreover,the correlations between patient features(age,sex,BMI,daily coffee and alcohol intake)and IBS and sleep disturbances were also ana-lyzed through our unitary model.Age was a signif icant regressor,with patients≤50 years old showing more severe bowel disturbances(posterior mean=-0.38,P<0.05)and less severe sleep disturbances(posterior mean=0.49,P<0.05)than older patients.Higher daily coffee intake was correlated with a lower sever-ity of bowel disturbances(posterior mean=-0.31,P<0.05).Sex(female)and daily alcohol intake(modest)were correlated with less severe sleep disturbances.CONCLUSION:The unitary bowel-sleep model based on IRT revealed a strong positive correlation between the severity of IBS symptoms and sleep disturbances. | Massimo Bellini Angelo Gemignani Dario Gambaccini Simona Toti Danilo Menicucci Cristina Stasi Francesco Costa Maria Gloria Mumolo Angelo Ricchiuti Remo Bedini Nicola de Bortoli Santino Marchi | 2011 | World Journal of Gastroenterology2011，17，46： | 17 |
| 2 | A peptide inhibitor of the uPA/uPAR system inhibits al- teration of the blood-retinal barrier in diabetes 显示文摘 | Navaratna D Menicucci G Maestas J Srinivasan R McGuire P Das A | 2008 | FASEB J2008，22，9： | 1 |
| 3 | Matrix metalloproteinases in early diabetic retinopathy and their role in alteration of the blood-retinal barrier显示文摘 | Giebel SJ Menicucci G Mc Guire PG | 2005 | Lab Invest2005，85，5： | 1 |
| 4 | Tooth-implant connection: some biomechanical aspects based on finite element analyses 显示文摘 | Menicucci G Mossolov A Mozzati M | 2002 | Clin Oral Implants Res2002，13，3： | 1 |
| 5 | Proteolytic deg- radation of VE-cadherin alters the blood-retinal barrier in diabe- tes 显示文摘 | Navaratna D McGuire PG Menicucci G Das A | 2007 | Diabetes2007，56，9： | 1 |
| 6 | Non - classic sHLA class Ⅰ in hu-man oocyte culture medium显示文摘 | Menicucci A | 1999 | Hum Immunol1999，60，11： | 1 |
| 7 | Non-classic sHLA class Ⅰ in human oocyte culture medium显示文摘 | Menicucci A Noci I Fuzzi B | 1999 | Hum Immunol1999，60，11： | 1 |
| 8 | Proteolytic degradation of VE-cadherin alters the blood-retinal barrier in diabetes显示文摘 | Navaratna D McGuire PG Menicucci G | 2007 | Diabetes2007，56，9： | 1 |
| 9 | Tooth-implant connection:some biomechanical aspects based on finite element analyses 显示文摘 | Menicucci G Mossolov A Mozzati M | 2002 | Clin Oral Impl Res2002，13，3： | 1 |
| 10 | Matrix metalloproteinases in early diabetic retinopathy and their role in alteration of the blood-retinal barrier显示文摘 | Giebel SJ Menicucci G Mc Guire PG Das A | 2005 | Lab Invest2005，85，5： | 1 |
| 11 | Tooth-implant connection:some biomechanical aspects based on finite element analyses显示文摘 | Menicucci G Mossolov A Mozzati M | 2002 | Clin Oral Implants Res2002，13，3： | 1 |
| 12 | Deriving the respiratory sinus arrhythmia from the heartbeat time series using empirical mode decomposition 显示文摘 | Balocchi R Menicucci D Santarcangelo E | 2004 | Chaos Solitons and Fractals2004，20，： | 1 |
| 13 | Procedure for determining maximum sustainable power generated by microbial fuel cells 显示文摘 | Menicucci J Beyenal H Marili E | 2006 | Environmental Science Technology2006，40，3： | 1 |
| 14 | Tooth - implant Connection:some Biomechanical Aspects Based on Finite Element Analyses显示文摘 | Menicucci G Mossolov A Mozzati M | 2002 | Clin Oral Implants Res2002，13，3： | 1 |
| 15 | Tooth-implant con- nection: some biomeehanical aspects based on finite element analyses 显示文摘 | Menicucci G Mossolov A Mozzati M | 2002 | Clin Oral Implants Res2002，13，3： | 1 |
| 16 | Minimal changes of thyroid axis activity influence brain functions in young females affected by subclinical hypothyroidism 显示文摘 | Menicucci D Sebastiani L Comparini A | 2013 | Arch Ital Biol2013，151，1： | 1 |
| 17 | Hepatocyte growlh factor/scatter factor promotes retinal angiogenesis through increased urokinase expression显示文摘 | Colombo KS Menicucci G McGuire PG | 2007 | Invest Ophthalrnol Vis Sci2007，48，4： | 1 |
| 18 | Mandibular implant-retainted overdenture:a clinical trim of two anchorage system显示文摘 | Menicucci G Lorenzetti M Pera P | 1998 | Int J Oral Maxil- lofac Implants1998，13，6： | 1 |
| 19 | Real time phase diversity advanced image processing and wavefront sensin显示文摘 | Dolne J J Menicucci P Miccolis D | 2007 | SPlE2007，6712，67： | 1 |
| 20 | Real time phase di- versity advanced image processing and wavefront sensing 显示文摘 | Dolne J J Menicucci P Miccolis D | 2007 | Proceedings of SHE2007，6712，67： | 1 |
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