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| 1 | Guanylyl cyclase C signaling axis and colon cancer prevention显示文摘Colorectal cancer(CRC) is a major cause of cancerrelated mortality and morbidity worldwide. While improved treatments have enhanced overall patient outcome, disease burden encompassing quality of life, cost of care, and patient survival has seen little benefit. Consequently, additional advances in CRC treatments remain important, with an emphasis on preventative measures. Guanylyl cyclase C(GUCY2C), a transmembrane receptor expressed on intestinal epithelial cells, plays an important role in orchestrating intestinal homeostatic mechanisms. These effects are mediated by the endogenous hormones guanylin(GUCA2A) and uroguanylin(GUCA2B), which bind and activate GUCY2 C to regulate proliferation, metabolism and barrier function in intestine. Recent studies have demonstrated a link between GUCY2 C silencing and intestinal dysfunction, including tumorigenesis. Indeed, GUCY2 C silencing by the near universal loss of its paracrine hormone ligands increases colon cancer susceptibility in animals and humans. GUCY2C's role as a tumor suppressor has opened the door to a new paradigm for CRC prevention by hormone replacement therapy using synthetic hormone analogs, such as the FDA-approved oral GUCY2 C ligand linaclotide(Linzess^(TM)). Here we review the known contributions of the GUCY2 C signaling axis to CRC, and relate them to a novel clinical strategy targeting tumor chemoprevention. | Amanda M Pattison Dante J Merlino Erik S Blomain Scott A Waldman | 2016 | World Journal of Gastroenterology2016，22，36： | 2 |
| 2 | Antioxidant micronutrients and risk of rheumatoidarthritis in a cohort of older women显示文摘 | Cerhan J R Saag K G Merlino L A | 2003 | Am J Epidemiol2003，157，4： | 1 |
| 3 | Evidence for the direct action of thymulin on avian NK cells 显示文摘 | Merlino P G Marsh J A | 2001 | Devel Compar Immunol2001，25，： | 1 |
| 4 | Electrocardiographic score and short-term outcomes of acute pulmonary embolism显示文摘 | TOOSI M S MERLINO J D LEEPER K V | 2007 | Am J Cardiol2007，100，： | 1 |
| 5 | Vitamin D intake is inversely associated with rheumatoid arthritis: results from the Iowa Women's Health Study显示文摘 | Merlino LA Curtis J Mikuls TR | 2004 | Arthritis Rheum2004，50，： | 1 |
| 6 | The effects of triodothyronine and thymulin on avian NK cytolytic activity显示文摘 | Marsh J A Merlino P G Staeheli P | 2001 | Int Immunopharmaeol2001，1，910： | 1 |
| 7 | Evaluation of chromogenic orientation for differentiation and presumptive identification of gram-negative bacilli and enterococcus species显示文摘 | Merlino J Siarakas S Robertson GJ | 1996 | J Clin Microbiol1996，34，1： | 1 |
| 8 | Vitamin D in- take is inversely associated with rheumatoid arthritis: results from the Iowa Women's Health Study显示文摘 | MERLINO L A CURTIS J MIKULS T R | 2004 | Arthritis Rheum2004，50，1： | 1 |
| 9 | Vitamin D intake is inversely associated with rheumatoid arthritis: results from the Iowa Women's Health Study显示文摘 | Merlino LA Curtis J Mikuls TR | 2004 | Arthritis Rheum2004，50，1： | 1 |
| 10 | Vitamin D intake is inversely associated with rheumatoid arthritis: results from the Lowa Women's Health Study 显示文摘 | MERLINO L A CURTIS J MIKULS T R | 2004 | Arthritis Rheum2004，50，1： | 1 |
| 11 | Detection and expression of methicillin/oxacillin resistance in multidrng-resistant and non-multi- drug-resistant Staphylococcus aureus in Central Sydney, Australia 显示文摘 | Merlino J Watson J Rose B | 2002 | The Journal of Antimicrobial Chemotherapy2002，49，5： | 1 |
| 12 | Animal models of melanoma:an HGF/SF transgenie mouse model may facili- tate experimental access to UV initiating events 显示文摘 | Noonan FP Dudek J Merlino G | 2003 | Pigment Cell Res2003，16，1： | 1 |
| 13 | Vitamin D intake is inversely associated with rheumatoidarthritis:results from the Iowa Women's Health Study显示文摘 | Merlino LA Curtis J Mikuls TR | 2004 | Arthritis Rheum2004，50，1： | 1 |
| 14 | Efficacy of two new systemic fungicides and thazole for control of Phytophthora root rot of Rhododendron, and spread of Phytophthora cinnamomi in progagation benches 显示文摘 | Englander L Merlino J A Mcguire J J | 1980 | Phytopathology1980，70，： | 1 |
| 15 | Usefulness of the peak velocity difference by tissue doppler imaging technique as an effective predictor of response to cardiac resynchronization therapy显示文摘 | Notabartolo D Merlino J D Smith A L | 2004 | Am J Cardiol2004，94，： | 1 |
| 16 | Vitamin D intake is inversely associated vdth rheumatoid arthritis: results from the Iowa Women' s Health Study显示文摘 | Merlino LA Curtis J Mikuls TR | 2004 | Arthritis Rheum2004，50，1： | 1 |
| 17 | Results of the Predictors of Response to CRT (PROSPECT) trial显示文摘 | Chung E S Leon A R Tavazzi L Sun J P Nihoyannopoulos P Merlino J | 2008 | Circulation2008，117，： | 1 |
| 18 | Prospective randomized trials affect the outcomes of intraabdominal infection显示文摘 | Malangoni M A Smith C M | 2001 | Ann Surg2001，233，6： | 1 |
| 19 | Vitamin D intake is inversely associated with rheumatoid arthritis: results from the Iowa Women's Health Study 显示文摘 | Merlino LA Curtis J Mikuls TR | 2004 | Arthritis and rheumatism2004，50，1： | 1 |
| 20 | Evidence for the diret action of thymulin on avian NK cells显示文摘 | Merlino P Marsh J A | 2001 | Develop Comp Immunol2001，25，： | 1 |
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