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| 1 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 2 | Human endometrial fluid kinetics as observed by scanning electron microscopy显示文摘 | Hafez E S E Ludwig H Metzger H | 1975 | Am J Obstet Gynecol1975，122，： | 2 |
| 3 | The transcriptional coactivator FHL2 transmits Rho signals from the cell membrane into the nucleus显示文摘 | MULLR J M METZGER E GRESCHIK H | 2002 | EMBO J2002，21，4： | 1 |
| 4 | Distribution, forma- tion, and molecular forms of the peptide xenin in various mammals 显示文摘 | Hamscher G Meyer H E Metzger J W | 1995 | Peptides1995，16，5： | 1 |
| 5 | The fifth edition of the addiction severity index 显示文摘 | McLellan AT Kushner H Metzger D | 1992 | J Subst Abuse Treat1992，9，3： | 1 |
| 6 | Cajal-like cells in the human upper urinary tract显示文摘 | Metzger R Schuster T Till H | 2004 | J Urol2004，172，2： | 1 |
| 7 | Reducing the rate of recurrent nerve paralysis by routine exposure of the nerves in thyroid gland operations显示文摘 | Mittig H Bildat D Metzger B | 1998 | Zentralbl Chir1998，123，1： | 1 |
| 8 | Endoscopic therapy for esophageal perforation or anastomotic leak with a self-expandable metallic stent显示文摘 | Jessica M. Leers Carlo Vivaldi Hartmut Sch?fer Marc Bludau Jan Brabender Georg Lurje Till Herbold Arnulf H. H?lscher Ralf Metzger | 2009 | Surgical Endoscopy2009，，10： | 1 |
| 9 | Coupled dynamics of the South China Sea, Sulu Sea, and the Pacific Ocean 显示文摘 | Metzger E J Hurlburt H | 1996 | J Geophys Res1996，101，12： | 1 |
| 10 | Gas evolution at graphite anodes depending on electrolyte water content and SEI quality studied by on-line electrochemical mass spectrometry显示文摘 | Bernhard R Metzger M Gasteiger H A | 2015 | Journal of the Electrochemical Society2015，162，10： | 1 |
| 11 | Coupled dynamics of the South Chi- na Sea, the Sulu Sea, and the Pacific Ocean 显示文摘 | Metzger E J Hurlburt H E | 1996 | Journal of Geo- physical Research1996，101，12： | 1 |
| 12 | Heat Transfer in the Tip Region of Grooved Turbine Blades显示文摘 | Chyu M K Moon H K Metzger D E | 1989 | ASME Journal of Turbomachinery1989，111，1： | 1 |
| 13 | The Fifth Edition of the Addiction Severity Index显示文摘 | McLellan AT Kushner H Metzger D | 1992 | J Subst Abuse Treat1992，9，3： | 1 |
| 14 | Future trends in the treat- ment of serions Gram - positive infection 显示文摘 | Metzger R Bonatti H Sawyer R | 2009 | Drugs Today ( Barc )2009，45，1： | 1 |
| 15 | Histolog-ic tumor type and the rate of complete response after neoadjuvanttherapy for esophageal cancer 显示文摘 | BOLLSCHWEILER E HoLSCHER A H METZGER R | 2010 | Future Oncol2010，6，1： | 1 |
| 16 | Quantitative O6-methylguanine-DNA methyltransferase methylation analysis in curatively resected non-small cell lung cancer: associations with clinical outcome显示文摘 | Brabender J Usadel H Metzger R | 2003 | Clin Cancer Res2003，9，1： | 1 |
| 17 | The transcriptional coactivator FHL2 transmits Rho signals from the cell membrane into the nucleus显示文摘 | Muller JM Metzger E Greschik H | 2002 | EMBO J2002，21，4： | 1 |
| 18 | Cajal-like cells in the human upper urinary tract 显示文摘 | Metzger R Schuster T Till H | 2004 | J Urol2004，172，2： | 1 |
| 19 | One gene,two transcripts:isolation of an alternative transcript encoding for the autoantigen La/SS-B from a cDNA library of a patient with primary Sjogrenssyndrome显示文摘 | TROSTER H METZGER TE SEMSEI I | 1994 | J Exp Med1994，180，6： | 1 |
| 20 | In-situ mercury speciation in flue gas by liquid and solid sorption systems显示文摘 | METZGER M BRAUN H | 1987 | Chemosphere1987，16，4： | 1 |
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