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| 1 | Prevalence of Thyroid Nodules and Its Relationship with Iodine Status in Shanghai:a Population-based Study显示文摘Objective This study was designed to evaluate the prevalence of thyroid nodules(TNs) and its relationship with urine iodine concentrations(UICs) after the regional rapid economic growth and lifestyle changes. Methods A cross-sectional survey was conducted in the general population aged 15-69 years. A questionnaire regarding general and personal characteristics and relevant information was administered. Ultrasonography of the thyroid was performed, and serum triiodothyronine(T3), tetraiodothyronine(T4), serum thyroid stimulating hormone(TSH), free triiodothyronine(FT3), free tetraiodothyronine(FT4), thyroglobulin antibody(Tg Ab), thyroid peroxidase antibody(TPOAb), and TSH receptor antibody(TRAb) levels were measured for each individual subject. Results The prevalence rates of TNs in the whole population, females and males were 27.76%, 34.04%, and 21.60%, respectively. The prevalence of multiple nodules increased with age, whereas the prevalence peaks differed between males and females. The median UICs in the whole population and females with non-TNs were higher than those of subjects with TNs(P=0.0035, P=0.0068). The median UICs in subjects with a single TN were higher than those in subjects with multiple TNs(P=0.0164, P=0.0127). The result showed a U-shaped curve relationship between UIC and prevalence of TNs. The prevalence of TNs was the lowest when the UIC was 140-400 μg/L. Conclusion The prevalence of TNs was nearly 30% and increased with age. The relationship between UIC and prevalence of TNs is U-shaped, with an increase in risk when the UIC was <140 μg/L and >400 μg/L. Very low or high UIC levels need attention and correction. | SONG Jun ZOU Shu Rong GUO Chang Yi ZANG Jia Jie ZHU Zhen Ni MI Ming HUANG Cui Hua YU Hui Ting LU Xi RUAN Ye WU Fan | 2016 | Biomedical and Environmental Sciences2016，29，6： | 25 |
| 2 | Discrimination of abiogenic and biogenic alkane gases显示文摘We have combined the analytical data of the carbon isotope distribution pattern, R/Ra and CH4/3He values of abiogenic and biogenic (referring to the thermogenic and bacterial or microbial) alkane gases in China with those of alkane gases from USA, Russia, Germany, Australia and other countries. Four discrimination criteria are derived from this comparative study: 1) Carbon isotopic composition is generally greater than -30‰ for abiogenic methane and less than -30‰ for biogenic methane; 2) Abiogenic alkane gases have a carbon isotopic reversal trend (δ 13C1> δ 13C2> δ 13C3> δ 13C4) with δ 13C1>-30‰ in general; 3) Gases with R/Ra >0.5 and δ 13C11 δ 13C2>0 are of abiogenic origin; 4) Gases (meth- ane) with CH4/3He≤106 are of abiogenic origin, whereas gases with CH4/3He≥1011 are of biogenic origin. | DAI JinXing ZOU CaiNeng ZHANG ShuiChang LI Jian NI YunYan HU GuoYi LUO Xia TAO ShiZhen ZHU GuangYou MI JingKui LI ZhiSheng HU AnPing YANG Chun ZHOU QingHua SHUAI YanHua ZHANG Ying MA ChengHua | 2008 | Science China Earth Sciences2008，51，12： | 17 |
| 3 | Synergistic antitumoral activity and induction of apoptosis by novel pan Bcl-2 proteins inhibitor apogossypolone with adriamycin in human hepatocellular carcinoma显示文摘瞄准:调查在里面 vitro 并且在 vivo 活动和 apogossypolone (ApoG2 ) 的相关机制独自或在有对人的 hepatocellular 癌(HCC ) 的 adriamycin (ADM ) 的联合。方法:在 vitro 的 ApoG2 的 IC 50 被 WST 试金测试,并且 synergistic 效果用 CalcuSyn 方法被分析。房间 apoptosis 用 4',6-diamidino-2-phenylindole 染色和流动 cytometric 分析被决定。西方的弄污被用来决定 apoptosis 相关的蛋白质的表示。在 vivo,活动在裸体老鼠在异种皮移植模特儿被评估,并且在肿瘤纸巾的 apoptosis 被终端 deoxynucleotidyl 决定标记的调停 transferase 的 digoxigenin-dUTP 刻痕结束(TUNEL ) 试金。结果:在 HCC 房间的 ApoG2 的 IC 50 是 17.28 30.63 μmol/L。当 ApoG2 与 ADM 被相结合时,增加的 cytotoxicity 和 apoptosis 独自与 ApoG2 与处理相比在 SMMC-7721 房间被观察。西方的弄污结果显示 ApoG2 在 SMMC-7721 房间导致了 apoptosis 由在调整 anti-apoptotic 蛋白质 Bcl-2, Mcl-1,和 Bcl-X L , 起来调整的 pro-apoptotic 蛋白质 Noxa,并且支持 caspases-9 和 -3 的活动。当没有引起损坏到正常纸巾, ApoG2 口头上地被管理时,异种皮移植 SMMC-7721 的肿瘤生长在裸体老鼠被禁止。在里面当在 100 或 200 mg/kg 剂量的 ApoG2 在 5.5 mg/kg 和 ADM 被使用时, vivo 学习也显示了增加的 anti-tumoral 效果,与相对肿瘤增长,率(T/C ) 分别地 0.456 和 0.323 珍视。与 ADM 独自一个或联合的 ApoG2 在 vivo 导致的 Apoptosis 被 TUNEL 试金在肿瘤纸巾证实。结论:ApoG2 是在调整 Noxa 上面导致 apoptosis 由的一个潜在的无毒的目标代理人,当禁止 anti-apoptotic 蛋白质并且在 HCC 支持化疗代理人 ADM 的效果时。 | Jin-xia MI Guang-feng WANG Heng-bang WANG Xiao-qing SUN Xin-yan NI Xiong-wen ZHANG Jia-ming TANG Da-jun YANG | 2008 | Acta Pharmacologica Sinica2008，29，12： | 16 |
| 4 | Environmental taxation and regional inequality in China显示文摘In order to combat environmental pollution, China enacted the Environmental Protection Tax Law in early 2018. Yet the impacts of the environmental tax on individual regions with different socioeconomic statuses, which are crucial for social justice and public acceptance, remain unclear. Based on a MultiRegional Input-Output(MRIO) table and a nationally regulated tax payment calculation method, this study analyzes the distributional impacts of an environmental tax based upon province’s consumption from both inter-provincial and rural-urban aspects. The national tax revenue based on the current levy mechanism is estimated to be only one seventh of the economic loss from premature mortality caused by ambient particulate matter(PM2.5). The taxation may slightly alleviate urban-rural inequality but may not be helpful with reducing inter-provincial inequality. We further analyze two alternative levy mechanisms. If each province imposes taxes to products it consumes(rather than produces, as in the current mechanism), with the tax rate linearly dependent on its per capita consumption expenditure, this would moderately increase the national tax revenue and significantly reduce inter-provincial inequality.To better compensate for the economic costs of air pollution and reduce regional inequality, it would be beneficial to increase the tax rate nationwide and implement a levy mechanism based on provincially differentiated levels of consumption and economic status. | Jingxu Wang Jintai Lin Kuishuang Feng Peng Liu Mingxi Du Ruijing Ni Lulu Chen Hao Kong Hongjian Weng Mengyao Liu Giovanni Baiocchi Yu Zhao Zhifu Mi Jing Cao Klaus Hubacek | 2019 | Science Bulletin2019，64，22： | 3 |
| 5 | Elicitor hydrophobin Hyd1 interacts with Ubiquilin1-like to induce maize systemic resistance显示文摘Trichoderma harzianum is a plant-beneficial fungus that secretes small cysteine-rich proteins that induce plant defense responses;however, the molecular mechanism involved in this induction is largely unknown.Here, we report that the class Ⅱ hydrophobin Th Hyd1 acts as an elicitor of induced systemic resistance(ISR) in plants. Immunogold labeling and immunofluorescence revealed Th Hyd1 localized on maize(Zea mays) root cell plasma membranes. To identify host plant protein interactors of Hyd1, we screened a maize B73 root c DNA library. Th Hyd1 interacted directly with ubiquilin1-like(UBL). Furthermore, the N-terminal fragment of UBL was primarily responsible for binding with Hyd1 and the eight-cysteine amino acid of Hyd1 participated in the protein-protein interactions. Hyd1 from T. harzianum(Thhyd1) and ubl from maize were co-expressed in Arabidopsis thaliana, they synergistically promoted plant resistance against Botrytis cinerea. RNA-sequencing analysis of global gene expression in maize leaves 24 h after spraying with Curvularia lunata spore suspension showed that Thhyd1-induced systemic resistance was primarily associated with brassinosteroid signaling, likely mediated through BAK1. Jasmonate/ethylene(JA/ET)signaling was also involved to some extent in this response. Our results suggest that the Hyd1-UBL axis might play a key role in inducing systemic resistance as a result of Trichoderma-plant interactions. | Chuanjin Yu Kai Dou Shaoqing Wang Qiong Wu Mi Ni Tailong Zhang Zhixiang Lu Jun Tang Jie Chen | 2020 | Journal of Integrative Plant Biology2020，62，4： | 1 |
| 6 | Coordinated shifts in Na/K-ATP ase isoforms and their endogenous ligands during cardiac hypertrophy and failure in NaCl-sensitive hypertension显示文摘 | Fedorova OV Talan MI Agalakova NI | 2004 | J Hypertens2004，22，2： | 1 |
| 7 | Reconstruction of damaged cornea by autologous transplantation of epidermal adult stem cells显示文摘 | Yang X Moldovan NI Zhao Q Mi S Zhou Z Chen D | 2008 | Mol Vis2008，14，： | 1 |
| 8 | 一株新型稻瘟霉素链霉菌JZB130180的鉴定及其对桃褐腐病的生防效果评价(英文)显示文摘目的:筛选对桃褐腐病有显著防效的链霉菌并解析其生防因子。创新点:本研究筛选到一株新型稻瘟霉素链霉菌JZB130180,其对桃褐腐病具有显著防效。通过对其生防因子解析及发酵液分析,为后续分离抑菌次生代谢物奠定了基础。方法:通过对峙培养和离体实验,检测链霉菌对桃褐腐病的抑制作用。通过平皿抑菌实验,计算链霉菌发酵液的室内毒力;随后进行了发酵液的理化性质检测。通过酶活力测定等,解析链霉菌中的生防因子。结论:链霉菌JZB130180及其发酵液对桃褐腐病具有显著的抑制作用。发酵液对桃褐腐病菌的半数有效抑制浓度(EC50)为38.3μg/mL,且对酸碱、温度和紫外线都有一定的耐受能力。此外,该菌株可以分泌几丁质酶、纤维素酶、蛋白酶等重要生防因子。 | Mi NI Qiong WU Hong-li WANG Wei-cheng LIU Bin HU Dian-peng ZHANG Juan ZHAO De-wen LIU Cai-ge LU | 2019 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2019，20，1： | 1 |
| 9 | Materials Chemistry and Physics显示文摘 | Yan Mi Ni Junjie Ma Tianyu | | 126: 1950，126，： | 1 |
| 10 | Reciprocal repression between TUSC 7 and mi R ‐23b in gastric cancer显示文摘 | Peng Qi Mi‐die Xu Xiao‐Han Shen Shu‐Juan Ni Dan Huang Cong Tan Wei‐Wei Weng Wei‐Qi Sheng Xiao‐Yan Zhou Xiang Du | 2015 | Cancer2015，，6： | 1 |
| 11 | Materials Letters显示文摘 | Ni Junjie Ma Tianyu Yan Mi | 2012 | 75:12012，75，： | 1 |
| 12 | Brain ouabain stimulates peripheral marinobufagenin via angiotensin Ⅱ signalling in NaCl-loaded Dahl-S rats显示文摘 | Fedorova OV Agalakova NI Talan MI | 2005 | J Hypertens2005，23，8： | 1 |
| 13 | Induced apoptosis supports spread of adenovirus vectors in tumors显示文摘 | Mi J Li ZY Ni S | 2001 | Hum Gene Ther2001，12，10： | 1 |
| 14 | Distribution of serotonin 2A ,2C and 3 receptor mRNA in spinal cord and medulla oblongata显示文摘 | Fonseca MI Ni YG Dunning DD Miledi R | 2001 | Brain Res Mol Brain Res2001，89，： | 1 |
| 15 | Cortisol and uncomplicated Plasmodium falciparum malaria in an area of unstable malaria transmission in eastern Sudan显示文摘Objective:To investigate the levels of serum Cortisol in patients with uncomplicated Plasmodium falciparum(P.falciparum) malaria in an area of unstable malaria transmission in eastern Sudan. Methods:The concentrations of Cortisol were measured in sera of 25 patients with uncomplicated P.fylciparum malaria(at presentation,24 h and 7 d later) and 25 healthy volunteers using radioimmunoassay gamma counter.Results:There was no significant difference in mean(SD) of total Cortisol levels in patients with malaria in comparison with the control group;602.2(369.6) vs. 449.2(311.7) ng/mL,P=0.12.In patients with uncomplicated P.falciparum malaria,the mean(SD) presenting Cortisol levels were significantly higher in comparison to the levels on day 7;602.2 (369.6) vs.373.6(139.1) ng/mL,P=0.009.In the patients with uncomplicated P.falciparum malaria (on presentation) Cortisol levels were not correlated with initial temperature or the presenting parasitaemia.Conclusions:Thus,Cortisol levels were not significantly different between the patients and the controls. | Ibrahim EA Kheir MM Elhardello OA Almahi WA Ali NI Elbashir MI Ishag Adam | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，2： | 1 |
| 16 | Laboratory diagnostic methods in primary pulmonary tuberculosis in adults显示文摘 | Platonovai L Lapovets NI | 1998 | Like Sprava1998，26，： | 1 |
| 17 | Permeability of blood-eye barrier in patients with primary glaucoma combined with lens opacity显示文摘 | Kurysheva NI Vinetskaia MI Erichev VP el al | 1998 | Vestn Oftalmol1998，114，6： | 1 |
| 18 | Estimation of characteristic damage time of food materials in pulsed-electric fields显示文摘 | Lebovka NI Bazhal MI Vorobiev El | 2002 | Journal of Fond Engineering2002，54，： | 1 |
| 19 | Effect of dietary zinc deficiency on hematological and biochemical parameters and concentrations of zinc, copper, and iron in growing rats显示文摘 | El Hendy HA Yousef MI Abo El- Naga NI | 2001 | Toxicology2001，167，2： | 1 |
| 20 | Acquired immune- deficiency syn-drome with focal onset of Mycobacterium avium infection displaying a histo-logical/genetic pattern of disseminated mycobacteria显示文摘 | Hibiya K Tateyama M Ni mi M | | 0，，21： | 1 |
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