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| 1 | Involvement of RhoA/ROCK in myocardial fibrosis in a rat model of type 2 diabetes显示文摘瞄准: 调查 RhoA/Rho kinase (岩石) 的激活是否在糖尿病的心涉及心肌的纤维变性。 | Hong ZHOU Yong-jun LI Mian WANG Li-hui ZHANG Zhan-sheng ZHAO Feng-ling MENG Yong-gui DENG Rui-ying WANG | 2011 | Acta Pharmacologica Sinica2011，32，8： | 32 |
| 2 | PROCESS CONTROL OF THE SAND WAVE MIGRATION IN BEIBU GULF OF THE SOUTH CHINA SEA显示文摘Based on the environment characteristics of the Beibu Gulf of South China Sea, a quasi-three-dimensional physical model is built.By coupling the bottom boundary layer with the two-dimensional tidal current field near the seabed surface, the quasi-three-dimensional hydrodynamic numerical simulation is carried out.The sand wave migration process is dealt with by coupling the hydrodynamic model with the sediment transport model.The computational results are shown to be in good agreement with the observed data, which indicates that the quasi-three-dimensional physical model can be used to simulate the migration process for small scale sand waves.Then, based on measured data, the evolution of the sand wave migration is investigated.An effective formula is developed to predict the migration rate, in which not only the effects of the environment but also the features of sand waves are considered. | LI yong LIN Mian JIANG Wen-bing FAN Feng-xin | 2011 | Journal of Hydrodynamics2011，23，4： | 15 |
| 3 | Space experimental studies of microgravity fluid science in China显示文摘Microgravity fluid physics is an important part of microgravity sciences, which consists of simple fluids of many new systems, gas-liquid two-phase flow and heat transfer, and complex fluid mechanics. In addition to the importance of itself in sciences and applications, microgravity fluid physics closely relates to microgravity combustion, space biotechnology and space materials science, and promotes the developments of interdisciplinary fields. Many space microgravity experiments have been performed on board the recoverable satellites and space ships of China and pushed the rapid development of microgravity sciences in China. In the present paper, space experimental studies and the main results of the microgravity fluid science in China in the last 10 years or so are introduced briefly. | HU WenRui LONG Mian KANG Qi XIE JingChang HOU MeiYing ZHAO JianFu DUAN Li WANG ShuangFeng | 2009 | Chinese Science Bulletin2009，54，22： | 10 |
| 4 | Receiver function analysis for seismic structure of the crust and uppermost mantle in the Liupanshan area, China显示文摘A portable broadband seismic array was deployed from the northeast Tibetan Plateau to the southwest Ordos block, China. The seismic structure of the crust and uppermost mantle of the Liupanshan area is obtained using receiver function analysis of teleseismic body waves. The crustal thickness and Poisson's ratios are estimated by stacking the weighted amplitudes of receiver functions. Our results reveal complex seismic phases in the Liupanshan area, implying intense deformation at the boundary between the Tibetan Plateau and the Ordos block. The average crustal thickness is 51.5 km in the northeast Tibetan Plateau, 53.5 km in the Liupan Mountain and 50 km in the southwest Ordos block, resulting in a concave Moho beneath the Liupan Mountain. The Poisson's ratio of the Liupanshan area varies between 0.27-0.29, higher than the value of 0.25-0.26 to the east and west of the Liupan Mountain, suggesting partial melting in the lower crust. The variance in Poisson's ratio across the Liupan Mountain indicates notable changes in the crustal composition and mechanical properties, which may be formed by the northeastward flow of the Tibetan lower crust during the India-Eurasia collision. | TONG WeiWei WANG LiangShu MI Ning XU MingJie LI Hua YU DaYong LI Cheng LIU ShaoWen LIU Mian Eric SanDvol | 2007 | Science China Earth Sciences2007，50，z2： | 9 |
| 5 | Identification of the deposited layers in landslides reservoir and investigation of the sediment yields during the later sixteenth century on the Hill Loess Plateau,China显示文摘There are many sediment trapping reservoirs in the Hill Loess Plateau.The Huangtuwa small catchment is selected as a research field where samples were collected in a sediment deposit profile with a vertical length of 12.73 m.By the variation of fine particle content and pollen concentration,54 flood couples were identified.Taking the freeze-thawing disturbed texture as the sign of the latest flood couple in a year,it is ascertained that those 54 floods should happen in 31 years.Using pyramid volume calculation formula,the sediment yields of flood ranged between 716―30376 t·km-2.The average sediment yield was 7106 t·km-2.The annual sediment yields varied between 968―55579 t·(km2·a) -1,and the average value is 12629 t·(km2·a) -1.Compared with the modern annual sediment discharge of the Huaining River,the erosion rate in the Huangtuwa region 450 years ago was similar to the modern erosion rate.In the period from the 27th year to the 31st year,the average annual sediment yield increased sharply to 31309 t·(km2·a) -1.It implied that re-reclamation of the abandoned land in the catchment since the landslide disaster,where vegetation had rehabilitated already,caused very severe soil erosion in the catchment. | LONG Yi ZHANG XinBao LI Min LI Mian ZHANG YunQi | 2008 | Chinese Science Bulletin2008，53，24： | 9 |
| 6 | A distinct pattern of memory and attention deficiency in patients with depression显示文摘 | LUO Lan-lan CHEN Xin CHAI Yan LI Jin-hong HANG Mian ZHANG Jian-ning | 2013 | Chinese Medical Journal2013，，6： | 9 |
| 7 | World’s first spaceflight on-orbit demonstration of a flexible solar array system based on shape memory polymer composites显示文摘With a 10%reversible compressive strain in more than 10 deformation cycles,the shape memory polymer composites(SMPCs)could be used for deployable structure and releasing mechanism.In this paper,without traditional electro-explosive devices or motors/controllers,the deployable SMPC flexible solar array system(SMPC-FSAS)is studied,developed,ground-based tested,and finally on-orbit validated.The epoxy-based SMPC is used for the rolling-out variable-stiffness beams as a structural frame as well as an actuator for the flexible blanket solar array.The releasing mechanism is primarily made of the cyanate-based SMPC,which has a high locking stiffness to withstand 50 g gravitational acceleration and a large unlocking displacement of 10 mm.The systematical mechanical and thermal qualification tests of the SMPC-FSAS flight hardware were performed,including sinusoidal sweeping vibration,shocking,acceleration,thermal equilibrium,thermal vacuum cycling,and thermal cycling test.The locking function of the SMPC releasing mechanisms was in normal when launching aboard the SJ20 Geostationary Satellite on 27 Dec.,2019.The SMPC-FSAS flight hardware successfully unlocked and deployed on 5 Jan.,2020 on geostationary orbit.The triggering signal of limit switches returned to ground at the 139 s upon heating,which indicated the successful unlocking function of SMPC releasing mechanisms.A pair of epoxy-based SMPC rolled variable-stiffness tubes,which clapped the flexible blanket solar array,slowly deployed and finally approached an approximate 100%shape recovery ratio within 60 s upon heating.The study and on-orbit successful validation of the SMPC-FSAS flight hardware could accelerate the related study and associated productions to be used for the next-generation releasing mechanisms as well as space deployable structures,such as new releasing mechanisms with low-shocking,testability and reusability,and ultra-large space deployable solar arrays. | LAN Xin LIU LiWu ZHANG FengHua LIU ZhengXian WANG LinLin LI QiFeng PENG Fan HAO SiDa DAI WenXu WAN Xue TANG Yong WANG Mian HAO YanYan YANG Yang YANG Cheng LIU YanJu LENG JinSong | 2020 | Science China(Technological Sciences)2020，63，8： | 7 |
| 8 | Neotuberostemonine inhibits the differentiation of lung fibroblasts into myofibroblasts in mice by regulating HIF-1α signaling显示文摘肺的纤维变性可以部分是响应长期的组织缺氧的 deregulated 织物修理的结果。在这研究,我们在肺成纤维细胞和 neotuberostemonine (NTS ) 的效果上探索了组织缺氧的效果,从 Stemona tuberosa 孤立的自然的碱,在在 vitro 并且在 vivo 的成纤维细胞的激活上。 PLF (主要老鼠肺成纤维细胞)与 CoCl 2( 100 mol/L )在暴露以后被激活并且区分到1% O 2或处理,由显著地增加的蛋白质或 HIF-1 ,TGF-, FGF2 , -SMA 和 Col-1/3 的 mRNA 表示证实了,它在 silencing HIF-1 以后被堵住,建议成纤维细胞的激活是 HIF-1-dependent 。而 NTS 的禁止的效果被合作处理与 MG132 废除, NTS (0.1-10 mol/L ) dose-dependently 压制了 PLF 的导致组织缺氧的激活和区别,一个 proteasome 禁止者。因为 prolyl hydroxylation 是在 HIF-1 降级的开始的关键步,我们进一步在 prolyl hydroxylated-HIF-1 的表示显示出导致组织缺氧的颠倒的那个 NTS 处理或 CoCl 2-induced 减小。与染色的 hypoxyprobe immunofiuorescence,我们证明 NTS 处理直接在暴露组织缺氧的 PLF 颠倒了更低的氧紧张。在肺纤维变性的一个老鼠模型, NTS 的口头的管理(30 mg ? 潭楤汯摩獥 ??? ‵貒?? | Xin-miao LV Ming-dan LI Si CHENG Bao-lin LIU Kang LIU Chao-feng ZHANG Xiang-hong XU Mian ZHANG | 2018 | Acta Pharmacologica Sinica2018，39，9： | 7 |
| 9 | Adsorptive hemofiltration for sepsis management: expert recommendations based on the Asia Pacific experience显示文摘To the Editor:In sepsis,bacterial endotoxins play a central role by inducing a dysregulated and exaggerated release of inflammatory mediators and cytokines,often described as the“cytokine storm”or“cytokinemia.”[1]Both endotoxins and cytokines have been implicated in the development of organ dysfunction,including acute kidney injury(AKI).[2]Removing circulating endotoxins and excess cytokines from the circulation restores chemotactic gradients,localizing the immune response to the principal site of infection and re-establishing a regulated immune response.[1,3]Therefore,using hemofilters with enhanced endotoxin and cytokine adsorptive properties may bring about additional therapeutic benefits compared with conventional continuous renal replacement therapy(CRRT)filters. | Ling Zhang Matthew Cove Binh G.Nguyen Nuttha Lumlertgul Kartik Ganesh Alfred Chan Giang T.H.Bui Chunwen Guo Junhua Li Songqiao Liu Mian Peng Kit W.Foong Jian Zhang Minmin Wang Jacques Goldstein Kai Harenski | 2021 | Chinese Medical Journal2021，，18： | 6 |
| 10 | Association of insulin-like growth factor-binding protein-3 with radiotherapy response and prognosis of esophageal squamous cell carcinoma显示文摘Background: Insulin?like growth factor?binding protein?3(IGFBP?3) is suggested to predict the radiosensitivity and/or prognosis of patients with esophageal squamous cell carcinoma(ESCC). The present study was designed to investi?gate the clinical and prognostic efects of IGFBP?3 on ESCC.Methods: IGFBP?3 was detected by immunohistochemistry in parain?embedded tissues from 70 ESCC patients treated with radiotherapy alone and further examined by western blotting analysis in 10 pairs of fresh ESCC tissues and adjacent non?malignant esophageal specimens. Receiver operating characteristic(ROC) analysis was used to determine cut?of scores for tumor positivity and to evaluate patient survival status. The χ2 test was performed to analyze the association of IGFBP?3 expression with clinical characteristics and radiotherapy response. Associations between prognostic outcomes and IGFBP?3 expression were investigated using Kaplan–Meier analysis and the Cox proportional hazards model.Results: The threshold for IGFBP?3 positivity was set to greater than 65% [area under the ROC curve(AUC)(45.7%) were deined as having high IGFBP?3 expression= 0.690, P < 0.019]. Of the 70 ESCC patient tissues tested, 32. The levels of IGFBP?3 protein expression were decreased in 70.0%(7 of 10) of ESCC tissues compared with adjacent non?malignant esophageal tissue. In addition, IGFBP?3 expression was associated with pathologic classiication(P < 0.05 for T, N, and M categories and clinical stage). Patients with elevated protein level of IGFBP?3 in the tumor had an improved radiotherapy response and prolonged overall survival(P < 0.001).Conclusions: High level of IGFBP?3 expression in ESCC associates with early clinical stages and are predictive for favorable survival of the patients treated with radiotherapy. | Li-Ling Luo Lei Zhao Mian Xi Li-Ru He Jing-Xian Shen Qiao-Qiao Li Shi-Liang Liu Peng Zhang Dan Xie Meng-Zhong Liu | 2015 | Chinese Journal of Cancer2015，34，11： | 6 |
| 11 | miRNA-181 regulates embryo implantation in mice through targeting leukemia inhibitory factor显示文摘Embryo implantation is a crucial step in mammalian reproduction.However,little is known regarding the physiological roles of microRNAs in the regulation of embryo implantation.Here we show that a minimum uterine expression of miR-181 is essential for the onset of embryo implantation.Both transient and prolonged transgenic expression of miR-181 led to impaired implantation,which can be rescued by exogenous administration of leukemia inhibitory factor(LIF).Mechanistically,miR-181 is able to directly target LIF and downregulate LIF expression,thereby inhibiting embryo implantation.We also show that miR-181 expression is regu-lated by the transcriptional factor Emx2,and the Emx2–miR-181 axis plays an importantrole in regulating embryo implantation.Taken together,these results reveal a novel function of miR-181 in embryo implantation through the regulation of LIF,and also indicate a potential link between miR-181 dysregulation and human embryo implantation defects. | Bo Chu Liangwen Zhong Shuang Dou Jun Wang Jianmin Li Mingwei Wang Qinghua Shi Yide Mei Mian Wu | 2015 | Journal of Molecular Cell Biology2015，7，1： | 5 |
| 12 | Effects of oriented substrates on cell morphology,the cell cycle,and the cytoskeleton in Ros 17/2.8 cells显示文摘Absence of gravity or microgravity influences the cellular functions of bone forming osteoblasts.The underlying mechanism,however,of cellular sensing and responding to the gravity vector is poorly understood.This work quantified the impact of vector-directional gravity on the biological responses of Ros 17/2.8 cells grown on upward-,downward-or edge-on-oriented substrates.Cell morphology and nuclear translocation,cell proliferation and the cell cycle,and cytoskeletal reorganization were found to vary significantly in the three orientations.All of the responses were duration-dependent.These results provide a new insight into understanding how osteoblasts respond to static vector-directional gravity. | LI Hong,CHEN Juan,ZHANG Yan,SUN ShuJin,TAO ZuLai & LONG Mian* Key Laboratory of Microgravity,Institute of Mechanics,Chinese Academy of Sciences,and National Microgravity Laboratory and Center for Biomechanics and Bioengineering,Institute of Mechanics,Chinese Academy of Sciences,Beijing 100190,China | 2010 | Science China(Life Sciences)2010，53，9： | 5 |
| 13 | Mechanokinetics of receptor-ligand interactions in cell adhesion显示文摘Receptor-ligand interactions in blood flow are crucial to initiate such biological processes as inflammatory cascade,platelet thrombosis,as well as tumor metastasis.To mediate cell adhesion,the interacting receptors and ligands must be anchored onto two apposing surfaces of two cells or a cell and a substratum,i.e.,two-dimensional(2D)binding,which is different from the binding of a soluble ligand in fluid phase to a receptor,i.e.,three-dimensional(3D) binding.While numerous works have been focused on3 D kinetics of receptor-ligand interactions in the immune system,2D kinetics and its regulations have been less understood,since no theoretical framework or experimental assays were established until 1993.Not only does the molecular structure dominate 2D binding kinetics,but the shear force in blood flow also regulates cell adhesion mediated by interacting receptors and ligands.Here,we provide an overview of current progress in 2D binding and regulations,mainly from our group.Relevant issues of theoretical frameworks,experimental measurements,kinetic rates and binding affinities,and force regulations are discussed. | Ning Li Shouqin Lü Yan Zhang Mian Long | 2015 | Acta Mechanica Sinica2015，31，2： | 5 |
| 14 | Smoking and Its Relation to Metabolic Status among Chinese Adults: Analysis of a Nationwide Survey显示文摘Objective To update the estimated prevalence rates of smoking and examine major metabolic diseases associated with smoking status in Chinese adults. Methods Using a complex, multistage, probability sampling design, we recruited a nationally representative sample of 98,658 Chinese adults aged ≥18 years in 2010. Information on current, former, never, and passive smoking status was obtained using a standard questionnaire. All estimates were weighted to represent the overall Chinese adult population. Results The estimated proportion of current smokers was 28.3% for Chinese adults aged ≥18 years. The corresponding values of former and passive smokers were 5.1% and 21.4%, respectively. Additionally, former smokers were found to have a less favorable metabolic risk profile among all categories of smoking status in both men and women. The prevalence of metabolic diseases such as diabetes and hypertension also increased with a greater number of smoking pack-years in men. Conclusion The prevalences of current smoking and passive smoking remain high in Chinese adults. | DING Lin XU Yu WANG Li Min JIANG Yong ZHANG Mei LI Yi Chong LU Jie Li XU Min WANG Tian Ge LI Mian ZHAO Zhi Yun DAI Meng WANG Wei Qing ZHAO Wen Hua WANG Lin Hong BI Yu Fang NING Guang 无 | 2016 | Biomedical and Environmental Sciences2016，29，9： | 5 |
| 15 | Association between Lipoprotein(a) Levels and Metabolic Syndrome in a Middle-aged and Elderly Chinese Cohort显示文摘Objective The association between lipoprotein(a)[Lp(a)] levels and metabolic syndrome(MetS) remains uncertain, especially in the Asian population. The purpose of this study was to demonstrate the association between Lp(a) levels and MetS in a middle-aged and elderly Chinese cohort. Methods A cross-sectional study of 10,336 Chinese adults aged 40 years or older was conducted in Jiading District, Shanghai, China. Logistic regression analysis was used to evaluate the association between serum Lp(a) levels and MetS. Results In the overall population, 37.5% of participants had MetS. Compared with individuals in the lowest quartile of serum Lp(a) levels, those in the highest quartile had a lower prevalence of MetS(30.9% vs. 46.9%, P for trend < 0.0001). Multivariate logistic regression analyses showed that compared with participants in the bottom quartile of serum Lp(a) levels, those in the top quartile had decreased odds ratio(OR) for prevalent MetS [multivariate-adjusted OR 0.45(95% confidence interval 0.39-0.51);P < 0.0001]. Additionally, Lp(a) level was conversely associated with the risk of central obesity, high fasting glucose, high triglycerides, and low HDL cholesterol, but not with hypertension. Stratified analyses suggested that increasing levels of Lp(a) was associated with decreased risk of MetS in all the subgroups. Conclusion Serum Lp(a) level was inversely associated with the risk of prevalent MetS in a middle-aged and elderly Chinese cohort. | WU Xue Yan LIN Lin Qi Hong Yan DU Rui HU Chun Yan MA Li Na PENG Kui LI Mian XU Yu XU Min CHEN Yu Hong LU Jie Li BI Yu Fang WANG Wei Qing NING Guang | 2019 | Biomedical and Environmental Sciences2019，32，7： | 5 |
| 16 | Influence of fault geometry and fault interaction on strain partitioning within western Sichuan and its adjacent region显示文摘There are several major active fault zones in the western Sichuan and its vicinity. Slip rates and seismicity vary on different fault zones. For example, slip rates on the Xianshuihe fault zone are higher than 10 mm/a. Its seismicity is also intense. Slip rates on the Longmenshan fault zone are low. However, Wenchuan Ms8.0 earthquake occurred on this fault zone in 2008. Here we study the impact of fault geometry on strain partitioning in the western Sichuan region using a three-dimensional viscoe- lastoplastic model. We conclude that the slip partitioning on the Xianshuihe-Xiaojiang fault presents as segmented, and it is related to fault geometry and fault structure. Slip rate is high on fault segment with simple geometry and structure, and vice versa. Strain rate outside the fault is localized around the fault segment with complex geometry and fault structure. Strain partitioning on the central section of the Xianshuihe-Xiaojiang fault zone is influenced by the interaction between the Anninghe-Zemuhe fault and the Daliangshan fault zone. Striking of the Longmenshan fault zone is nearly orthogonal to the direction of eastward extrusion in the Tibetan Plateau. It leads to low slip rate on the fault zone. | WANG Hui LIU Jie SHEN XuHui LIU Mian LI QingSong SHI YaoLin ZHANG GuoMin | 2010 | Science China Earth Sciences2010，53，7： | 5 |
| 17 | Monoterpene and tetrahydronaphthene derivatives from Senecio argunensis显示文摘二新混合物, senarguines A 和 B,从 Senecio argunensis 被孤立。他们分别地作为(Z)-3-ethylidene-9-hydroxyl-9-methyl-6,7-dioxaspiro 被识别[4.4 ] nonane-5,8– dione (1 ) 和 3,6,6-trimethyl 6,7,8-tetrahydronaphtha-[1,2b ] 呋喃(2 ) 根据光谱数据。 | Chao Feng Zhang Ning Li Lin Li Mian Zhang | 2009 | Chinese Chemical Letters2009，20，5： | 4 |
| 18 | Co-administration of paroxetine and pravastatin causes deregulation of glucose homeostasis in diabetic rats via enhanced paroxetine exposure显示文摘 | Feng LI Mian ZHANG Dan XU Can LIU Ze-yu ZHONG Ling-ling JIA Meng-yue HU Yang YANG Li LIU Xiao-dong LIU | 2014 | Acta Pharmacologica Sinica2014，35，6： | 4 |
| 19 | Laminaria japonica increases plasma exposure of glycyrrhetinic acid following oral administration of Liquorice extract in rats显示文摘The present study was designed to investigate the effects of Laminaria japonica(Laminaria) on pharmacokinetics of glycyrrhetinic acid(GA) following oral administration of Liquorice extract in rats.Following oral administrations of single-dose and multi-dose Liquorice extract and Liquorice-Laminaria extract,respectively,plasma samples were obtained at various times and the concentrations of GA,liquiritigenin,and isoliquiritigenin were measured by LC-MS.The effects of Laminaria extract on pharmacokinetics of GA were also investigated,following single-dose and multidose of glycyrrhizic acid(GL).The effects of Laminaria extract on intestinal absorption of GA and GL were studied using the in situ single-pass intestinal perfusion model.The metabolism of GL to GA in the contents of small and large intestines was also studied.The results showed Liquorice-Laminaria extract markedly increased the plasma concentration of GA,accompanied by a shorter Tmax.Similar alteration was observed following multidose administration.However,pharmacokinetics of neither liquiritigenin nor isoliquiritigenin was affected by Laminaria.Similarly,Laminaria markedly increased concentration and decreased Tmax of GA following oral GL were observed.The data from the intestinal perfusion model showed that Laminaria markedly increased GL absorption in duodenum and jejunum,but did not affect the intestinal absorption of GA.It was found that Laminaria enhanced the metabolism of GL to GA in large intestine.In conclusion,Laminaria increased plasma exposures of GA following oral administration of liquorice or GL,which partly resulted from increased intestinal absorption of GL and metabolism of GL to GA in large intestine. | ZHAO Wei-Man JIANG Shu-Wen CHEN Yang ZHONG Ze-Yu WANG Zhong-Jian ZHANG Mian LI Ying XU Ping LIU Li LIU Xiao-Dong | 2015 | Chinese Journal of Natural Medicines2015，13，7： | 4 |
| 20 | Ciprofloxacin blocked enterohepatic circulation of diclofenac and alleviated NSAID-induced enteropathy in rats partly by inhibiting intestinal 13-glucuronidase activity显示文摘瞄准:Diclofenac 是 non-steroidal 反煽动性的药(NSAID ) ,它可以引起严肃的肠的不利反应(enteropathy ) 。在这研究,我们调查了 ciprofloxacin 的合作管理是否在 rats.Methods 影响了 diclofenac 和导致 diclofenac 的 enteropathy 的 pharmacokinetics:diclofenac 的 pharmacokinetics 在收到 diclofenac 以后在老鼠被估计(10 mg/kg, ig,或 5 mg/kg, iv ) ,与或没有 ciprofloxacin (20 mg/kg, ig ) 共同管理。在收到 6 口头的剂量或 diclofenac 的 15 静脉内的剂量以后,老鼠被牺牲,并且小肠被移开检验导致 diclofenac 的 enteropathy。β在肠的满意的、牛的肝和 E coli 的 -Glucuronidase 活动是 evaluated.Results:后面的口头或静脉内的管理, diclofenac 的 pharmacokinetic 侧面显示了废除的 ciprofloxacin 的典型 enterohepatic 循环,和合作管理 enterohepatic 发行量,在 diclofenac 的血浆内容导致了重要减小。在控制老鼠, β在小肠的内容的 -glucuronidase 活动是区域依赖者:近似 intestine<远侧的 intestine< ileal 阀门。ciprofloxac 的管理引起了 β 的重要减小;在远侧的小肠,并且特别地在 ileal 的 -glucuronidase 活动阀门。而且, ciprofloxacin (10-2000 μ mol/L ) dose-dependently 禁止的 β在远侧的小肠内容的 -glucuronidase 活动或 E coli 在 vitro 孵化了,但是没在在 vitro 孵化的近似的小肠内容或牛的肝影响那。在收到 6 口头的剂量或 diclofenac 的 15 静脉内的剂量以后,典型 enteropathy 与严重 enteropathy 被开发发生在远侧的小肠。ciprofloxacin 的合作管理显著地减轻了导致 diclofenac 的 enteropathy.Conclusion:ciprofloxacin 的合作管理稀释了 diclofenac 的 enterohepatic 循环并且在老鼠减轻了导致 diclofenac 的 enteropathy,部分经由肠的 β 的抑制; -glucuronidase 活动。 | Ze-yu ZHONG Bin-bin SUN Nan SHU Qiu-shi XIE Xiange TANG Zhao-li LING Fan WANG Kai-jing ZHAO Ping XU Mian ZHANG Ying LI Yang CHEN Li LIU Lun-zhu XIA Xiao-dong LIU | 2016 | Acta Pharmacologica Sinica2016，37，7： | 4 |
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